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ATCAY encodes a neuron-restricted protein that contains a CRAL-TRIO motif common to proteins that bind small lipophilic molecules. Additionally we are shipping Ataxia, Cerebellar, Cayman Type Proteins (5) and Ataxia, Cerebellar, Cayman Type Kits (1) and many more products for this protein.
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caytaxin binds to kinesin-1 and functions as an adaptor that mediates intracellular transport of specific cargos, one of which is the mitochondrion.
Caytaxin is a novel substrate of caspase-3 (show CASP3 Antibodies), which is cleaved upstream of the CRAL-TRIO (show TRIO Antibodies)/BCH (show CHN2 Antibodies) domain and which regulates MEK2 (show MAP2K2 Antibodies) signaling
Mutations of mouse Atcay are an orthologous gene model for human Cayman ataxia.
The classical hesitant allele of Atcay is partially suppressed by CAST/Ei alleles of the nuclear export factor Nxf1 (show NXF1 Antibodies).
This gene encodes a neuron-restricted protein that contains a CRAL-TRIO motif common to proteins that bind small lipophilic molecules. Mutations in this gene are associated with cerebellar ataxia, Cayman type.
, Cayman ataxia
, ataxia cayman type protein