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Ataxin 1 Proteins (ATXN1)

The autosomal dominant cerebellar ataxias (ADCA) are a heterogeneous group of neurodegenerative disorders characterized by progressive degeneration of the cerebellum, brain stem and spinal cord. Additionally we are shipping Ataxin 1 Antibodies (197) and Ataxin 1 Kits (33) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ATXN1 6310 P54253
ATXN1 20238 P54254
Rat ATXN1 ATXN1 25049 Q63540
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Top Ataxin 1 Proteins at antibodies-online.com

Showing 7 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Mouse His tag,T7 tag 100 μg Log in to see 11 to 13 Days
$823.90
Details
HOST_Escherichia coli (E. coli) Human His tag,T7 tag 100 μg Log in to see 11 to 13 Days
$756.80
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 9 to 19 Days
$936.27
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

ATXN1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine)
,

Top referenced Ataxin 1 Proteins

  1. Human Ataxin 1 Protein expressed in Wheat germ - ABIN1346189 : Yoon, Abdelmohsen, Kim, Yang, Martindale, Tominaga-Yamanaka, White, Orjalo, Rinn, Kreft, Wilson, Gorospe: Scaffold function of long non-coding RNA HOTAIR in protein ubiquitination. in Nature communications 2013 (PubMed)

More Proteins for Ataxin 1 (ATXN1) Interaction Partners

Fruit Fly (Drosophila melanogaster) Ataxin 1 (ATXN1) interaction partners

  1. Ataxin-1 induces intranuclear accumulation of dAtx2/hAtaxin-2 in both Drosophila and SCA1 postmortem neurons

  2. mutant ataxin-1 and huntingtin (show HTT Proteins) induce developmental and late-onset neuronal pathologies in Drosophila models

Human Ataxin 1 (ATXN1) interaction partners

  1. This study reports the results of molecular dynamics simulations of AXH monomer of Ataxin-1.

  2. Systematic replacement of each lysine residue in the AXH domain revealed that the lysine at 589 (K589) of ATXN1 is essential for its ubiquitylation by UbcH6 (show UBE2E1 Proteins).

  3. Results show that two SNPs in ATXN1 gene have a founder effect of the same repeat carrying allele as in the general Indian population suggesting that that Spinocerebellar ataxia (show USP14 Proteins) type 1 disease onset is significantly delayed when transmission is maternal.

  4. this work provides the structural and molecular basis of the interaction between RBM17 (show RBM17 Proteins) and the phosphorylated form of ATXN1.

  5. Partner recognition of the AXH domain of the transcriptional co-regulator ataxin-1 is fine-tuned by a subtle balance between self- and hetero-associations.

  6. We measured cerebellar neurochemical alterations in a knock-in mouse model of spinocerebellar ataxia (show USP14 Proteins) type 1, a hereditary movement disorder, using ultra-high field magnetic resonance spectroscopy (MRS).

  7. Data indicate that the alternative ataxin-1 (ATXN1) protein is constitutively co-expressed and interacts with ATXN1.

  8. SCA 1 was the most frequent occurring type of SCA identified in the Autosomal dominant hereditary ataxia (show USP14 Proteins) in Sri (show SRI Proteins) Lanka.

  9. Results show variation in ATXN1 is implicated in disordered gambling

  10. conformational heterogeneity of the AXH domain of ataxin-1

Mouse (Murine) Ataxin 1 (ATXN1) interaction partners

  1. The results of this study found that upregulation of cholecystokinin (Cck (show CCK Proteins)) and subsequent interaction with the Cck1 (show CCL28 Proteins) receptor likely underlies the lack of progressive Purkinje cell pathology in Pcp2-ATXN1[30Q]D776 mice.

  2. Mutant ATXN1 forms oligomers whose levels correlate with disease progression in the Atxn1154Q/+ mice.

  3. The study showed that Sca1(+)Lin(-) bone marrow contains an endodermal precursor population of cells that differentiates into hepatocytes.

  4. HMGB1 (show HMGB1 Proteins) facilitates repair of mitochondrial DNA damage of mutant ataxin-1 knock-in mice.

  5. The RNA-binding protein PUMILIO1 (PUM1 (show PUM1 Proteins)) not only directly regulates ATAXIN1 but also plays an unexpectedly important role in neuronal function. Loss of Pum1 (show PUM1 Proteins) caused progressive motor dysfunction and SCA1-like neurodegeneration with motor impairment, primarily by increasing Ataxin1 levels.

  6. study found a new function of ataxin-1: the modulation of Pp2a (show PPP2R2B Proteins) activity and the regulation of its holoenzyme composition, with the polyglutamine mutation within Atxn1 altering this function in the spinocerebellar ataxia (show USP14 Proteins) type 1 mouse cerebellum before disease onset

  7. Delivery of either ataxin-1-like (show ATXN1L Proteins) viral vectors to Spinocerebellar Ataxia (show USP14 Proteins) Type 1 mice cerebella resulted in widespread cerebellar Purkinje cell transduction

  8. downregulation of several components of the RAS-MAPK (show MAPK1 Proteins)-MSK1 (show RPS6KA5 Proteins) pathway decreases ATXN1 levels and suppresses neurodegeneration in mice

  9. we show that ATXN1 reduces histone acetylation, a post-translational modification of histones associated with enhanced transcription, and represses histone acetyl transferase (show HAT1 Proteins)-mediated transcription.

  10. Loss of ATXN1, Atxn1L and CIC is associated with hydrocephalus, omphalocele, and lung alveolarization defects.

Ataxin 1 (ATXN1) Protein Profile

Protein Summary

The autosomal dominant cerebellar ataxias (ADCA) are a heterogeneous group of neurodegenerative disorders characterized by progressive degeneration of the cerebellum, brain stem and spinal cord. Clinically, ADCA has been divided into three groups: ADCA types I-III. ADCAI is genetically heterogeneous, with five genetic loci, designated spinocerebellar ataxia (SCA) 1, 2, 3, 4 and 6, being assigned to five different chromosomes. ADCAII, which always presents with retinal degeneration (SCA7), and ADCAIII often referred to as the `pure' cerebellar syndrome (SCA5), are most likely homogeneous disorders. Several SCA genes have been cloned and shown to contain CAG repeats in their coding regions. ADCA is caused by the expansion of the CAG repeats, producing an elongated polyglutamine tract in the corresponding protein. The expanded repeats are variable in size and unstable, usually increasing in size when transmitted to successive generations. The function of the ataxins is not known. This locus has been mapped to chromosome 6, and it has been determined that the diseased allele contains 41-81 CAG repeats, compared to 6-39 in the normal allele, and is associated with spinocerebellar ataxia type 1 (SCA1). At least two transcript variants encoding the same protein have been found for this gene.

Gene names and symbols associated with Ataxin 1 Proteins (ATXN1)

  • ataxin 1 (ATXN1)
  • ataxin 1b (atxn1b)
  • Ataxin 1 (Atx-1)
  • ataxin 1 (Atxn1)
  • ataxin 1-like (ATXN1L)
  • 2900016G23Rik protein
  • ataxin 1b protein
  • Atx1 protein
  • atxn1 protein
  • C85907 protein
  • CG4547 protein
  • D6S504E protein
  • dAtx-1 protein
  • dAtx1 protein
  • Dmel\\CG4547 protein
  • ENSMUSG00000074917 protein
  • Gm10786 protein
  • sca1 protein

Protein level used designations for Ataxin 1 Proteins (ATXN1)

ataxin 1 , spinocerebellar ataxia type 1 , Ataxin1 , Atx-1-PB , CG4547-PB , ataxin-1 , ataxin-1-like , spinocerebellar ataxia type 1 protein , spinocerebellar ataxia 1 homolog , spinocerebellar ataxia 1 , spinocerebellar ataxia type 1 protein homolog , spinocerebellar ataxia type 1 protien

GENE ID SPECIES
100065748 Equus caballus
493678 Felis catus
565841 Danio rerio
747421 Pan troglodytes
31624 Drosophila melanogaster
100025666 Monodelphis domestica
100402564 Callithrix jacchus
100437511 Pongo abelii
100467930 Ailuropoda melanoleuca
100588152 Nomascus leucogenys
6310 Homo sapiens
20238 Mus musculus
25049 Rattus norvegicus
488232 Canis lupus familiaris
100154571 Sus scrofa
616399 Bos taurus
100719683 Cavia porcellus
420843 Gallus gallus
101113284 Ovis aries
489725 Canis lupus familiaris
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