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Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Additionally we are shipping Ataxin 1-Like Antibodies (18) and many more products for this protein.
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Both ATXN1 (show ATXN1 Proteins) and BOAT1 bind to the promoter region of Hey1 (show HEY1 Proteins) and inhibit the transcriptional output of Notch (show NOTCH1 Proteins) through direct interactions with CBF1 (show RBPJ Proteins), a transcription factor that is crucial for the Notch (show NOTCH1 Proteins) pathway.
Boat is an in vivo binding partner of ataxin-1 (show ATXN1 Proteins) whose altered expression in Purkinje cells may contribute to their degeneration in causes spinocerebellar ataxia (show USP14 Proteins) type 1 animals
Results provide genetic evidence that the selective neuropathology of Spinocerebellar ataxia (show USP14 Proteins) type 1 arises from modulation of a core functional activity of ataxin-1 (show ATXN1 Proteins)
Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression. Can suppress ATXN1 cytotoxicity in spinocerebellar ataxia type 1 (SCA1) (By similarity).
, brother of ATXN1
, brother of ataxin-1