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anti-Ataxin 3 (ATXN3) Antibodies

Machado-Joseph disease, also known as spinocerebellar ataxia-3, is an autosomal dominant neurologic disorder. Additionally we are shipping Ataxin 3 Proteins (15) and Ataxin 3 Kits (4) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
ATXN3 4287 P54252
ATXN3 110616 Q9CVD2
ATXN3 60331 O35815
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Top anti-Ataxin 3 Antibodies at antibodies-online.com

Showing 10 out of 58 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated EIA, IHC (p), WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated IHC (p) Formalin-fixed and paraffin-embedded human cancer tissue reacted with ... 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated FACS, IHC (p), WB Western blot analysis of ATXN3 Antibody (Center) (ABIN653191) in MCF-7... Formalin-fixed and paraffin-embedded human brain tissue reacted with A... 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated EIA, FACS, IHC (p), WB ATXN3 Antibody (Center) FC analysis of ZR-75-1 cells (bottom histogram... Formalin-fixed and paraffin-embedded human brain tissue reacted with A... 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Mouse Un-conjugated EIA, FACS, IHC (p), WB 0.1 mL Log in to see 6 to 8 Days
$522.50
Details
Human Rabbit Un-conjugated WB WB Suggested Anti-ATXN3 Antibody Titration: 0.2-1 ug/mlPositive Contro... WB Suggested Anti-ATXN3  Antibody Titration: 0.2-1 µg/mL  Positive Con... 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated IHC (p), WB Anti- Ataxin 3 Picoband antibody, Western blotting All lanes: Anti Ata... Anti- Ataxin 3 Picoband antibody, IHC(P) IHC(P): Human Lung Cancer Tis... 100 μg Log in to see 4 to 6 Days
$240.00
Details
Human Rabbit Un-conjugated IHC (p), WB Anti-Ataxin 3 antibody, IHC(P) IHC(P): Human Lung Cancer Tissue 100 μg Log in to see 4 to 6 Days
$200.00
Details
Human Rabbit Un-conjugated ICC, IF, WB ICC/IF Image Immunofluorescence analysis of paraformaldehyde-fixed HeL... WB Image Ataxin 3 antibody detects Ataxin 3 protein by western blot an... 100 μL Log in to see 2 to 3 Days
$358.60
Details
Human Mouse Un-conjugated WB 100 μg Log in to see 10 to 12 Days
$244.59
Details

ATXN3 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality
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Top referenced anti-Ataxin 3 Antibodies

  1. Human Polyclonal Ataxin 3 Primary Antibody for EIA, IHC (p) - ABIN357621 : Albrecht, Golatta, Wüllner, Lengauer: Structural and functional analysis of ataxin-2 and ataxin-3. in European journal of biochemistry / FEBS 2004 (PubMed)
    Show all 5 references for ABIN357621

  2. Human Monoclonal Ataxin 3 Primary Antibody for WB - ABIN2666310 : Li, Macfarlan, Pittman, Chakravarti: Ataxin-3 is a histone-binding protein with two independent transcriptional corepressor activities. in The Journal of biological chemistry 2002 (PubMed)
    Show all 4 references for ABIN2666310

  3. Human Polyclonal Ataxin 3 Primary Antibody for EIA, FACS - ABIN950546 : Reina, Zhong, Pittman: Proteotoxic stress increases nuclear localization of ataxin-3. in Human molecular genetics 2009 (PubMed)
    Show all 2 references for ABIN950546

  4. Human Monoclonal Ataxin 3 Primary Antibody for EIA, FACS - ABIN781665 : Trottier, Cancel, An-Gourfinkel, Lutz, Weber, Brice, Hirsch, Mandel: Heterogeneous intracellular localization and expression of ataxin-3. in Neurobiology of disease 1999 (PubMed)
    Show all 2 references for ABIN781665

  5. Human Polyclonal Ataxin 3 Primary Antibody for FACS, IHC (p) - ABIN653191 : Jung, Xu, Lessing, Bonini: Preventing Ataxin-3 protein cleavage mitigates degeneration in a Drosophila model of SCA3. in Human molecular genetics 2009 (PubMed)
    Show all 2 references for ABIN653191

More Antibodies against Ataxin 3 Interaction Partners

Human Ataxin 3 (ATXN3) interaction partners

  1. South American cohort did not confirm the effect of the four candidate loci as modifier of onset age: mithocondrial A10398G polymorphism and CAGn at RAI1 (show DOM3Z Antibodies), CACNA1A (show CACNA1A Antibodies), ATXN3, and ATXN7 (show ATXN7 Antibodies) genes

  2. Ataxin-3 phosphorylation decreases neuronal defects in spinocerebellar ataxia (show USP14 Antibodies) type 3 models.

  3. USP19_b up-regulates the protein levels of the polyglutamine (polyQ)-containing proteins, ataxin-3 (Atx3) and huntingtin (Htt (show HTT Antibodies)), and thus promotes aggregation of their polyQ-expanded species in cell models

  4. Based on these data and other related studies, we presumed that de novo mutations of ATXN3 emerging from large ANs are at least one survival mechanisms of mutational ATXN3 and we can redefine the range of CAG repeats as: ANsAIs (show AR Antibodies) AEs (show AES Antibodies)>/=50

  5. Results suggest that the aggregation of Josephin proceeds from the monomer state to the formation of spheroidal intermediates with a native structure. Only successively, these intermediates evolve into misfolded aggregates and into the final fibrils.

  6. Data show that homozygosity for Machado-Joseph disease (MJD)/SCA3 protein enhances the clinical severity of the disease.

  7. A multistage aggregation mechanism for ataxin-3 is described in which flanking domain self-assembly precedes polyglutamine aggregation yet is influenced by polyglutamine expansion.

  8. Ubiquitination of ataxin-3 is not necessary for its proteasomal degradation.Ataxin-3 is regulated by ubiquitin-binding site 2 on its N terminus.Ubiquitin-binding site 2 of ataxin-3 prevents its proteasomal degradation by interacting with Rad23.

  9. Machado-Joseph disease patients carrying the rs709930 A allele and rs910369 T allele of ATXN3 experienced an earlier age of onset of approximately 2 to 4 years.

  10. polyglutamine expansion increases the molecular mobility of two juxtaposed helices critical to ataxin-3 deubiquitinase activity

Mouse (Murine) Ataxin 3 (ATXN3) interaction partners

  1. We show that chronic VPA treatment did not modify the ATXN3 inclusion load and astrogliosis in affected brain regions However, VPA chronic treatment was able to increase GRP78 (show HSPA5 Antibodies) protein levels at 30 weeks of age, one of its known neuroprotective effects

  2. work suggests that in Machado-Joseph disease, mutant ataxin-3 drives an abnormal reduction of ataxin-2 (show ATXN2 Antibodies) levels, which overactivates poly(A)-binding protein, increases translation of mutant ataxin-3 and other proteins and aggravates Machado-Joseph disease.

  3. SCA3 knockin mice exhibit robust Atxn3 accumulation both in regions known to be affected in human disease; also display altered splicing of the mutant Atxn3 transcript that results in the formation of a previously described alternative ATXN3 transcript

  4. Data support the importance of ATXN3 in neuronal cells and indicate that an expanded polyQ tract leads to a partial loss of the cellular function of ATXN3 that may be relevant to neurodegeneration.

  5. While ataxin-3 may participate in protein quality control pathways, it does not critically regulate the handling of mutant htt (show HTT Antibodies) or contribute to major features of disease pathogenesis in Huntington disease (show HTT Antibodies).

  6. Results suggest that postnatal nuclear accumulation of mutant ataxin-3 disrupts dendritic differentiation and mGluR (show GRM8 Antibodies)-signaling in mouse model spinocerebellar ataxia (show USP14 Antibodies) type 3 Purkinje cells

  7. Lentiviral-based expression of mutant atxn-3 in the mouse cerebellum induces localized neuropathology sufficient to generate a behavioral ataxic phenotype.

  8. Cerebellar soluble mutant ataxin-3 level decreases during disease progression in Spinocerebellar Ataxia (show USP14 Antibodies) Type 3 mice.

  9. the efficacy of gene silencing in blocking the MJD-associated motor-behavior and neuropathological abnormalities

  10. the sequestration of misfolded SOD1 (show SOD1 Antibodies) into aggresomes, which is driven by ataxin-3, plays an important role in attenuating protein misfolding-induced cell toxicity.

Ataxin 3 (ATXN3) Antigen Profile

Protein Summary

Machado-Joseph disease, also known as spinocerebellar ataxia-3, is an autosomal dominant neurologic disorder. The protein encoded by this gene contains (CAG)n repeats in the coding region, and the expansion of these repeats from the normal 13-36 to 68-79 is one cause of Machado-Joseph disease. There is a negative correlation between the age of onset and CAG repeat numbers. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Gene names and symbols associated with anti-Ataxin 3 (ATXN3) Antibodies

  • ataxin 3 (atxn3) antibody
  • ataxin 3 (ATXN3) antibody
  • ataxin-3 (MICPUN_104046) antibody
  • ataxin-3 (MICPUCDRAFT_46658) antibody
  • ataxin 3 (Atxn3) antibody
  • 2210008M02Rik antibody
  • AI463012 antibody
  • AI647473 antibody
  • AT3 antibody
  • ataxin-3 antibody
  • ATX3 antibody
  • ATXN3 antibody
  • JOS antibody
  • MGC83584 antibody
  • MJD antibody
  • MJD1 antibody
  • Rsca3 antibody
  • Sca3 antibody
  • zgc:56323 antibody

Protein level used designations for anti-Ataxin 3 (ATXN3) Antibodies

ataxin-3 , ataxin 3 , ataxin-3-like , Machado-Joseph disease (spinocerebellar ataxia 3, olivopontocerebellar ataxia 3, autosomal dominant, ataxin 3) , Machado-Joseph disease protein 1 , ataxin 3 variant h , ataxin 3 variant m , ataxin 3 variant ref , josephin , olivopontocerebellar ataxia 3 , spinocerebellar ataxia type 3 protein , Machado-Joseph disease (spinocerebellar ataxia 3, olivopontocerebellar ataxia 3, autosomal dominant, ataxin 3) homolog , machado-Joseph disease protein 1 homolog

GENE ID SPECIES
394079 Danio rerio
480229 Canis lupus familiaris
549143 Xenopus (Silurana) tropicalis
738729 Pan troglodytes
790880 Bos taurus
100144422 Sus scrofa
100171397 Ovis aries
444085 Xenopus laevis
100393557 Callithrix jacchus
8249057 Micromonas sp. RCC299
9682664 Micromonas pusilla CCMP1545
4287 Homo sapiens
110616 Mus musculus
60331 Rattus norvegicus
378424 Gallus gallus
Selected quality suppliers for anti-Ataxin 3 (ATXN3) Antibodies
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