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Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Additionally we are shipping ATXN7L3 Proteins (3) and many more products for this protein.
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Human Monoclonal ATXN7L3 Primary Antibody for IP, WB - ABIN2668618
Zhao, Lang, Ito, Bonnet, Metzger, Sawatsubashi, Suzuki, Le Guezennec, Stunnenberg, Krasnov, Georgieva, Schüle, Takeyama, Kato, Tora, Devys: A TFTC/STAGA module mediates histone H2A and H2B deubiquitination, coactivates nuclear receptors, and counteracts heterochromatin silencing. in Molecular cell 2008
ATXN7L3 and ENY2 orchestrate activities of multiple deubiquitinating enzymes, including USP27x and USP51, and that imbalances in these activities likely potentiate human diseases including cancer.
Downregulation of ATXN7L3 by short hairpin RNA speci fi cally inactivated the SAGA deubiquitination activity, leading to a strong increase of global H2B ubiquitination and a moderate increase of H2A ubiquitination.
The solution structures of the SCA7 (show ATXN7 Antibodies) domain of both ATXN7 (show ATXN7 Antibodies) and ATXN7L3 reveal a new, common zinc-finger motif at the heart of two distinct folds, providing a molecular basis for the observed functional differences.
ATXN7L3, USP22 (show USP22 Antibodies), & ENY2 (show ENY2 Antibodies) are required cofactors for full transcriptional activity by nuclear receptors. The deubiquitinase activity of TFTC/STAGA HAT (show MGEA5 Antibodies) counteracts heterochromatin silencing & is a positive cofactor for in vivo nuclear receptor activation.
Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates histone H2B. The SAGA complex is recruited to specific gene promoters by activators, where it is required for transcription (By similarity).
SAGA-associated factor 11 homolog
, ataxin-7-like protein 3