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Atlastin GTPase 1 Proteins (ATL1)

The protein encoded by ATL1 is a GTPase and a Golgi body transmembrane protein. Additionally we are shipping ATL1 Antibodies (57) and ATL1 Kits (4) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ATL1 51062 Q8WXF7
ATL1 73991 Q8BH66
Rat ATL1 ATL1 362750 Q6PST4
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Top ATL1 Proteins at antibodies-online.com

Showing 7 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
HOST_Baculovirus infected Insect Cells Human GST tag 100 μg Log in to see 16 Days
$437.80
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

ATL1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , ,
, ,
Mouse (Murine) ,
,

More Proteins for Atlastin GTPase 1 (ATL1) Interaction Partners

Zebrafish Atlastin GTPase 1 (ATL1) interaction partners

  1. This study suggests that atlastin may regulate BMP receptor (show BMPR1A Proteins) trafficking. and genetic or pharmacological inhibition of BMP signaling was sufficient to rescue the loss of mobility and spinal motor axon defects of atl1 morphants.

Human Atlastin GTPase 1 (ATL1) interaction partners

  1. We identified two novel mutations and two previously reported mutations in SPAST (show SPAST Proteins) and ATL1, respectively. The family with the ATL1 c.1204T>G mutation exhibited male-lethality, female infancy-onset, and pseudo- X-linked dominant transmission

  2. Novel splicing pathogenic variants were identified in ATL1 genes of Korean patients with hereditary spastic paraplegia.

  3. a deficit in the membrane fusion activity of atlastin1 may be a key contributor, but is not required, for hereditary spastic paraplegia causation.

  4. These results suggest that the three ATLs have different capacities to mediate endoplasmic reticulum fusion, with ATL1 being the strongest and ATL3 (show ATL3 Proteins) being the weakest.

  5. purified and reconstituted human ATL1 exhibited no in vitro fusion activity. When the cytosolic segment of human ATL1 was connected to the transmembrane (TM) region and C-terminal tail (CT) of Drosophila ATL

  6. Data showed 3 micro-mutations and 2 exon deletions in SPAST (show SPAST Proteins) gene and 2 micro-mutations in ATL1 gene in this cohort of Chinese patients with spastic paraplegia.

  7. Our combined findings show that homozygosity for the ATL1 missense variant remains the only plausible cause of Hereditary spastic paraplegias, whereas heterozygous carriers are asymptomatic.

  8. These data suggest that the C-terminal tail of Atlastin locally destabilizes bilayers to facilitate membrane fusion.

  9. The atlastin-mediated fusion of ER membranes is important for LD size regulation.

  10. The hydrophobic domains of protrudin (show ZFYVE27 Proteins) likely adopt hairpin topologies, similar to those in the atlastins, as well as the ER-shaping reticulons and REEPs. Protrudin (show ZFYVE27 Proteins) interacts with these protein families through the hydrophobic segments.

Mouse (Murine) Atlastin GTPase 1 (ATL1) interaction partners

  1. VCP (valosin-containing protein (show vcp Proteins)), together with its cofactor P47 (show MFGE8 Proteins) and the endoplasmic reticulum (ER) morphology regulator ATL1 (Atlastin-1), regulates tubular ER formation

  2. This publication discusses functional and mutational aspects of atlastin GTPase 1 in humans.

ATL1 Protein Profile

Protein Summary

The protein encoded by this gene is a GTPase and a Golgi body transmembrane protein. The encoded protein can form a homotetramer and has been shown to interact with spastin and with mitogen-activated protein kinase kinase kinase kinase 4. This protein may be involved in axonal maintenance as evidenced by the fact that defects in this gene are a cause of spastic paraplegia type 3. Three transcript variants encoding two different isoforms have been found for this gene.

Gene names and symbols associated with Atlastin GTPase 1 Proteins (ATL1)

  • atlastin GTPase 1 (ATL1)
  • atlastin GTPase 1 (atl1)
  • atlastin GTPase 1 (LOC100347174)
  • atlastin GTPase 1 (Atl1)
  • 4930435M24Rik protein
  • AD-FSP protein
  • Adfsp protein
  • ATL1 protein
  • atlastin protein
  • Atlastin-1 protein
  • atlastin1 protein
  • fj46c01 protein
  • Fsp1 protein
  • GBP3 protein
  • HSN1D protein
  • MGC146251 protein
  • Spg3 protein
  • Spg3a protein
  • wu:fj46c01 protein

Protein level used designations for Atlastin GTPase 1 Proteins (ATL1)

atlastin GTPase 1 , spastic paraplegia 3A (autosomal dominant) , atlastin-1 , atlastin-1-like , GBP-3 , GTP-binding protein 3 , brain-specific GTP-binding protein , guanine nucleotide-binding protein 3 , guanylate-binding protein 3 , hGBP3 , spastic paraplegia 3 protein A , spastic paraplegia 3A homolog

GENE ID SPECIES
467452 Pan troglodytes
480318 Canis lupus familiaris
571909 Danio rerio
779669 Xenopus (Silurana) tropicalis
100158193 Sus scrofa
100413587 Callithrix jacchus
100347174 Oryctolagus cuniculus
100603089 Nomascus leucogenys
51062 Homo sapiens
73991 Mus musculus
362750 Rattus norvegicus
535424 Bos taurus
100173943 Pongo abelii
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