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This protein belongs to the basic helix-loop-helix (BHLH) family of transcription factors. Additionally we are shipping ATOH1 Antibodies (142) and ATOH1 Kits (5) and many more products for this protein.
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A genetic network of sensory determinant, Atoh1 (and Sox9a), play critical roles in otic neural development.
Sox2 (show SOX2 Proteins) and Fgf interact with Atoh1 to promote sensory competence throughout the zebrafish inner ear.
Atoh1a expression must be restricted by Notch (show NOTCH1 Proteins) signaling for effective morphogenesis of the posterior lateral line primordium in zebrafish.
in the zebrafish, two proneural genes are essential for differentiation of the hair cells, neuroD and atonal homolog 1
atoh1.2 and beta3.1 (show BHLHE22 Proteins) are transcribed in distinct precursors.
ATOH1 expression was detected consistently in recurrent and metastatic SHH medulloblastoma. Chromatin immunoprecipitation sequencing and gene expression profiling identified candidate ATOH1 targets in tumor cells involved in development and tumorigenesis.
These data indicate that the regulation of Atoh1 by the ubiquitin proteasome pathway is necessary for hair cell fate determination and survival.
ATOH1 is increased in advanced Merkel cell carcinoma (MCC (show MCC Proteins)) indicating that ATOH1 is involved in MCC (show MCC Proteins) progression.
Study provides evidence that Sox2 (show SOX2 Proteins) expression is required for the late stages of progenitor cell differentiation to hair cells and stimulates Atoh1 expression through a concentration dependent molecular interaction with the 3' enhancer of Atoh1.
Downregulation of Hath1 expression promoted the proliferation and reduced the apoptosis of KUMA5 squamous cell carcinoma cells.
ATOH1 can induce the differentiation of gastric cancer stem cells.
ATOH1 acts in concert with other transcription factors to directly regulate the cochlear hair cell phenotype.
Testosterone-bovine serum albumin (show ALB Proteins) and Math1 treatment could promote an increase in hair-cell like cells in the lesser epithelial ridge through proliferation and transdifferentiation.
Atoh1 epigenetic regulation guides hair cell development in the mammalian cochlea
Atoh1 protein stabilization induced both a cancer stem cell phenotype and a mucinous phenotype, resulting in the acquisition of chemoresistance in colorectal cancer
This study illustrates a SHH (show SHH Proteins)-Stox1-Math1 regulatory axis in normal cerebellar development and medulloblastoma formation.
This work reveals a dynamic ATOH1-driven molecular cascade underlying medulloblastoma metastasis that offers possible therapeutic opportunities
The discovery that Atonal homolog 1 (Atoh1) governs the development of the sensory hair cells in the inner ear led to therapeutic efforts to restore these cells in cases of human deafness.
miR (show MLXIP Proteins)-183 family expression in combination with Atoh1 not only appears to fine tune gene expression in favor of hair cells fate, but is also required for the expression of some hair cell-specific genes.
These data illuminate a genetic pathway that initiates auditory HC regeneration and suggest p27(Kip1 (show CDKN1B Proteins)), GATA3 (show GATA3 Proteins), and POU4F3 (show POU4F3 Proteins) as additional therapeutic targets for ATOH1-mediated auditory hair cells regeneration.
Hes (show ATCAY Proteins)/Hey signaling at the Atoh1 promoter has a role in selection of cell fate in the organ of Corti
The retrotrapezoid nucleus neurons expressing Atoh1 and Phox2b (show PHOX2B Proteins) are essential for the respiratory response to CO2.
propose Atoh1 neurons tune the sequential activation of independent oscillators essential for the fine control of different muscles during breathing
our data indicate that beta-catenin (show CTNNB1 Proteins) and Atoh1 mediate synergistic effects on both proliferation and differentiation of a subset of neonatal cochlear Lgr5 (show LGR5 Proteins)+ cells
This protein belongs to the basic helix-loop-helix (BHLH) family of transcription factors. It activates E-box dependent transcription along with E47.
, protein atonal homolog 1
, atonal homolog 1 (Drosophila)
, absent MD neurons and olfactory sensilla
, atonal homolog 1
, class A basic helix-loop-helix protein 14
, helix-loop-helix protein hATH-1
, helix-loop-helix protein mATH-1
, atonal 1