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anti-Autoimmune Regulator (AIRE) Antibodies

AIRE encodes a transcriptional regulator that forms nuclear bodies and interacts with the transcriptional coactivator CREB binding protein. Additionally we are shipping AIRE Kits (40) and AIRE Proteins (3) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
AIRE 326 O43918
AIRE 294328  
AIRE 11634 Q9Z0E3
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Top anti-AIRE Antibodies at antibodies-online.com

Showing 10 out of 162 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-AIRE Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:1562500Positive Control: HepG2 cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated IHC, WB WB Suggested Anti-AIRE Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:1562500Positive Control: Human Liver 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated WB WB Suggested Anti-AIRE Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:62500Positive Control: Human Placenta 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$229.00
Details
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of extracts from HeLa cells treated with Hu 2nM 24h, using AIRE (Phospho-Ser156) Antibody. The lane on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated IF, ELISA, WB Western blot analysis of extracts from 293 cells, using AIRE Antibody. The lane on the right is treated with the synthesized peptide. Immunofluorescence analysis of HeLa cells, using AIRE Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of extracts from HeLa cells, treated with Hu 2nM 24h, using AIRE (Ab-156) Antibody. The lane on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Goat Un-conjugated IHC, ELISA, WB ABIN185643 staining (0.05µg/ml) of HEK293 cell lysates. Untransfected (Lane 3) and transfected with Human AIRE (lane 4). Data kindly provided by Prof. Pärt Peterson, University of Tartu, Estonia. ABIN185643 (2.5µg/ml) staining of paraffin embedded Human Thymus. Steamed antigen retrieval with citrate buffer pH 6, AP-staining. 100 μg Log in to see 4 to 5 Days
$318.20
Details
Human Rabbit Un-conjugated IF, WB AIRE Antibody (Center)  western blot analysis in mouse kidney tissue lysates (35ug/lane).This demonstrates the AIRE antibody detected the AIRE protein (arrow). Confocal immunofluorescent analysis of AIRE Antibody (Center) with 293 cell followed by Alexa Fluor® 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Goat Un-conjugated WB AP26005PU-N (0.3 µg/ml) staining of human spleen lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 0.1 mg Log in to see 6 to 8 Days
$379.50
Details

AIRE Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Mouse (Murine) , , ,
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Top referenced anti-AIRE Antibodies

  1. Human Polyclonal AIRE Primary Antibody for IHC, ELISA - ABIN185643 : Niki, Oshikawa, Mouri, Hirota, Matsushima, Yano, Han, Bando, Izumi, Matsumoto, Nakayama, Kuroda, Matsumoto: Alteration of intra-pancreatic target-organ specificity by abrogation of Aire in NOD mice. in The Journal of clinical investigation 2006 (PubMed)
    Show all 3 references for ABIN185643

  2. Cow (Bovine) Polyclonal AIRE Primary Antibody for IHC, WB - ABIN2779777 : Ilmarinen, Kangas, Kytömaa, Eskelin, Saharinen, Seeler, Tanhuanpää, Chan, Slattery, Alakurtti, Palvimo, Ulmanen: Functional interaction of AIRE with PIAS1 in transcriptional regulation. in Molecular immunology 2008 (PubMed)
    Show all 2 references for ABIN2779777

  3. Human Polyclonal AIRE Primary Antibody for IF, WB - ABIN655031 : Conteduca, Ferrera, Pastorino, Fenoglio, Negrini, Sormani, Indiveri, Scarrà, Filaci: The role of AIRE polymorphisms in melanoma. in Clinical immunology (Orlando, Fla.) 2010 (PubMed)

  4. Human Polyclonal AIRE Primary Antibody for ELISA, WB - ABIN1533151 : Hattori, Fujiyama, Taylor, Watanabe, Yada, Park, Toyoda, Ishii, Totoki, Choi, Groner, Soeda, Ohki, Takagi, Sakaki, Taudien, Blechschmidt, Polley, Menzel, Delabar, Kumpf, Lehmann, Patterson, Reichwald et al.: The DNA sequence of human chromosome 21. ... in Nature 2000 (PubMed)

  5. Cow (Bovine) Polyclonal AIRE Primary Antibody for WB - ABIN2779775 : Akiyoshi, Hatakeyama, Pitkänen, Mouri, Doucas, Kudoh, Tsurugaya, Uchida, Matsushima, Oshikawa, Nakayama, Shimizu, Peterson, Matsumoto: Subcellular expression of autoimmune regulator is organized in a spatiotemporal manner. in The Journal of biological chemistry 2004 (PubMed)

  6. Human Polyclonal AIRE Primary Antibody for WB - ABIN2779776 : Tao, Kupfer, Stewart, Williams-Skipp, Crowell, Patel, Sain, Scheinman: AIRE recruits multiple transcriptional components to specific genomic regions through tethering to nuclear matrix. in Molecular immunology 2005 (PubMed)

More Antibodies against AIRE Interaction Partners

Human Autoimmune Regulator (AIRE) interaction partners

  1. androgen control of an intrathymic Aire-mediated tolerance mechanism contributes to gender differences in autoimmunity.

  2. results indicate that in females, estrogen induces epigenetic changes in the AIRE gene, leading to reduced AIRE expression under a threshold that increases female susceptibility to autoimmune diseases.

  3. The rs2075876 and rs760426 loci of the AIRE gene are associated with increased risk for rheumatoid arthritis among ethnic Han Chinese from ShaanXi.

  4. The novel mutation of c.622G>T (p.G208W) in AIRE gene is associated autoimmune polyendocrinopathy syndrome type I.

  5. AIRE-655GAIRE-230T haplotype could dramatically alter AIRE transcription.

  6. In the current study, we demonstrate that AIRE activates the expression of transiently transfected luciferase reporters that lack defined promoter regions, as well as intron and poly(A) signal sequences.

  7. These results suggest that Aire expression is inherent to all medullary thymic epithelial cells (mTECs) but may occur at particular stage(s) and/or cellular states during their differentiation, thus accounting for the broad impact of Aire on the promiscuous gene expression of mTECs.

  8. Keratopathy can be an early and severe manifestation of APS1, which contributes to the global prognosis of the disease. Its mechanisms remain to be elucidated.

  9. Molecular characterization of the functional domains of Aire has revealed multiple binding partners that assist Aire's function in altering gene transcription and chromatin remodeling.

  10. study identified a novel AIRE mutation which alters the intracellular location and transcription activity of AIRE, and has implications in the pathogenesis of autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy

Mouse (Murine) Autoimmune Regulator (AIRE) interaction partners

  1. Aire may have a role in inducing Th1 (show HAND1 Antibodies) and Th17 differentiation by upregulating cytokine expression in dendritic cells.

  2. androgen control of an intrathymic Aire-mediated tolerance mechanism contributes to gender differences in autoimmunity.

  3. results indicate that in females, estrogen induces epigenetic changes in the AIRE gene, leading to reduced AIRE expression under a threshold that increases female susceptibility to autoimmune diseases.

  4. Our results identify Aire as an important regulator of peripheral T cell homeostasis in gastrointestinal tissues. Given a suitable trigger the absence of peripheral Aire leads to dysregulated T cell proliferation and disease.

  5. Data indicate a highly conserved noncoding DNA element that is essential for Autoimmune regulator (Aire) gene expression.

  6. Molecular characterization of the functional domains of Aire has revealed multiple binding partners that assist Aire's function in altering gene transcription and chromatin remodeling.

  7. Aire expression in thymic epithelial cells was decreased in germ-free mice without commensal bacteria.

  8. Aire's collaboration with the bromodomain-containing protein, Brd4 (show BRD4 Antibodies), uncovered correspondence between those genes induced by Aire and those inhibited by a small-molecule bromodomain blocker.

  9. Aire increased the diversity of the thymic epithelial cell transcriptome and seemed to target genes expressed in a minority of cells, and increased expression of its target genes.

  10. Data indicate that keratin 17 (k17 (show KRT17 Antibodies)) regulates autoimmune regulator Aire to promote skin tumorigenesis.

AIRE Antigen Profile

Protein Summary

This gene encodes a transcriptional regulator that forms nuclear bodies and interacts with the transcriptional coactivator CREB binding protein. The encoded protein plays an important role in immunity by regulating the expression of autoantigens and negative selection of autoreactive T-cells in the thymus. Mutations in this gene cause the rare autosomal-recessive systemic autoimmune disease termed autoimmune polyendocrinopathy with candidiasis and ectodermal dystrophy (APECED).

Gene names and symbols associated with AIRE

  • autoimmune regulator (AaeL_AAEL013794) antibody
  • autoimmune regulator (CpipJ_CPIJ001208) antibody
  • autoimmune regulator (CpipJ_CPIJ001209) antibody
  • autoimmune regulator (AIRE) antibody
  • autoimmune regulator (Aire) antibody
  • autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy) (Aire) antibody
  • autoimmune regulator-like (LOC100621659) antibody
  • AIRE1 antibody
  • APECED antibody
  • APS1 antibody
  • APSI antibody
  • PGA1 antibody

Protein level used designations for AIRE

autoimmune regulator , autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein , autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy) , APECED protein homolog , autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein homolog , autoimmune regulator AIRE1a

GENE ID SPECIES
5578645 Aedes aegypti
6032239 Culex quinquefasciatus
6032240 Culex quinquefasciatus
326 Homo sapiens
784775 Bos taurus
294328 Rattus norvegicus
487796 Canis lupus familiaris
100729880 Cavia porcellus
429666 Gallus gallus
101102698 Ovis aries
11634 Mus musculus
100621659 Sus scrofa
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