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AIRE encodes a transcriptional regulator that forms nuclear bodies and interacts with the transcriptional coactivator CREB binding protein. Additionally we are shipping AIRE Antibodies (154) and AIRE Proteins (3) and many more products for this protein.
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results indicate that in females, estrogen induces epigenetic changes in the AIRE gene, leading to reduced AIRE expression under a threshold that increases female susceptibility to autoimmune diseases.
The rs2075876 and rs760426 loci of the AIRE gene are associated with increased risk for rheumatoid arthritis among ethnic Han Chinese from ShaanXi.
The novel mutation of c.622G>T (p.G208W) in AIRE gene is associated autoimmune polyendocrinopathy syndrome type I.
AIRE-655GAIRE-230T haplotype could dramatically alter AIRE transcription.
In the current study, we demonstrate that AIRE activates the expression of transiently transfected luciferase reporters that lack defined promoter regions, as well as intron and poly(A) signal sequences.
These results suggest that Aire expression is inherent to all medullary thymic epithelial cells (mTECs) but may occur at particular stage(s) and/or cellular states during their differentiation, thus accounting for the broad impact of Aire on the promiscuous gene expression of mTECs.
Keratopathy can be an early and severe manifestation of APS1, which contributes to the global prognosis of the disease. Its mechanisms remain to be elucidated.
Molecular characterization of the functional domains of Aire has revealed multiple binding partners that assist Aire's function in altering gene transcription and chromatin remodeling.
study identified a novel AIRE mutation which alters the intracellular location and transcription activity of AIRE, and has implications in the pathogenesis of autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy
Data indicate that autoimmune regu (show KRT17 ELISA Kits)lator Aire mRNA transcripts are regulated in a keratin 17 (K17) dependent manner in skin tumor keratinocytes.
Our results identify Aire as an important regulator of peripheral T cell homeostasis in gastrointestinal tissues. Given a suitable trigger the absence of peripheral Aire leads to dysregulated T cell proliferation and disease.
Data indicate a highly conserved noncoding DNA element that is essential for Autoimmune regulator (Aire) gene expression.
Aire expression in thymic epithelial cells was decreased in germ-free mice without commensal bacteria.
Aire's collaboration with the bromodomain-containing protein, Brd4 (show BRD4 ELISA Kits), uncovered correspondence between those genes induced by Aire and those inhibited by a small-molecule bromodomain blocker.
Aire increased the diversity of the thymic epithelial cell transcriptome and seemed to target genes expressed in a minority of cells, and increased expression of its target genes.
Data indicate that keratin 17 (k17 (show KRT17 ELISA Kits)) regulates autoimmune regulator Aire to promote skin tumorigenesis.
Data show that sirtuin 1 (Sirt-1 (show SIRT1 ELISA Kits)) mediated deacetylation of Aire protein was required for the transcriptional-transactivational potential of Aire.
AIRE-dependent versus AIRE-independent tissue-restricted antigens project nonredundant representations of peripheral tissues in the thymus.
This gene encodes a transcriptional regulator that forms nuclear bodies and interacts with the transcriptional coactivator CREB binding protein. The encoded protein plays an important role in immunity by regulating the expression of autoantigens and negative selection of autoreactive T-cells in the thymus. Mutations in this gene cause the rare autosomal-recessive systemic autoimmune disease termed autoimmune polyendocrinopathy with candidiasis and ectodermal dystrophy (APECED).
, autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein
, autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy)
, APECED protein homolog
, autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein homolog
, autoimmune regulator AIRE1a