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Autophagy is a process of bulk protein degradation in which cytoplasmic components, including organelles, are enclosed in double-membrane structures called autophagosomes and delivered to lysosomes or vacuoles for degradation. Additionally we are shipping ATG12 Antibodies (202) and ATG12 Proteins (19) and many more products for this protein.
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Analysis of hepatitis B virus capsid maturation steps revealed that Rab33B and Atg5/12/16L1 are required for proper particle assembly and/or stability.
reveal a novel interconnection between autophagy, proteasome activity, and cell death mediated by the ubiquitin-like properties of ATG12
The results revealed that the expression of Atg12 and LC3 (show MAP1LC3A ELISA Kits) II/LC3 (show MAP1LC3A ELISA Kits) I in the chondrocytes treated with TXC increased, compared to that in the untreated chondrocytes
Cav-1 competitively interacts with the ATG12-ATG5 system to suppress the formation and function of the latter in lung epithelial cells.
ATG12 is a novel determinant of breast cancer primary resistance to HER1 (show EGFR ELISA Kits)/2-targeted therapeutics.
study to identify role of conjugation between ATG12 and ATG5 in LC3 lipidation; structural and mutational analyses of ATG12~ATG5-ATG16N revealed the conjugation generates a patch across ATG12 and ATG5 required for E3 activity
These data relate LC3B, ATG5 and ATG12 to mitochondrial quality control after oxidative damage, and to cellular longevity.
The Atg12 is as a positive mediator of mitochondrial apoptosis and show that Atg12 directly regulates the apoptotic pathway by binding and inactivating prosurvival Bcl-2 (show BCL2 ELISA Kits) family members, including Bcl-2 (show BCL2 ELISA Kits) and Mcl-1 (show MCL1 ELISA Kits).
Calpain1 plays an important role in controlling the levels of autophagy in normal living cells by regulating the levels of a key signaling molecule, ATG12-ATG5 conjugate.
Human Apg3p (show ATG3 ELISA Kits)/Aut1p homologue is an authentic E2 enzyme for multiple substrates, GATE-16 (show GABARAPL2 ELISA Kits), GABARAP (show GABARAP ELISA Kits), and MAP-LC3 (show MAP1LC3A ELISA Kits), and facilitates the conjugation of hApg12p to hApg5p
Although genetic deletion of either Atg12 or Atg5 (show ATG5 ELISA Kits) renders POMC (show POMC ELISA Kits) neurons autophagy-deficient, mice lacking Atg5 (show ATG5 ELISA Kits) in POMC (show POMC ELISA Kits) neurons do not exhibit these phenotypes.
ATG12-ATG3 (show ATG3 ELISA Kits) interacts with Alix (show PDCD6IP ELISA Kits) to promote basal autophagic flux and late endosome function.
Atg5 (show ATG5 ELISA Kits)-Atg12/Atg16L1 (show ATG16L1 ELISA Kits) protein complex is required for IFNgamma-mediated host defense against murine norovirus infection.
Vaccinia virus actively disrupts the cellular autophagy through a novel molecular mechanism that is associated with aberrant LC3 (show MAP1LC3A ELISA Kits) lipidation and a direct conjugation between ATG12 and ATG3 (show ATG3 ELISA Kits).
Despite forming the Atg12-Atg5-Atg16L2 complex, Atg16L2 is not recruited to phagophores and is mostly present in the cytosol.
Autophagy participated the process of immune response of anti-MTB (show NCAPG2 ELISA Kits). Atg12 were the important molecule which control the formation of autophagy when MTB (show NCAPG2 ELISA Kits) infected.
Overexpression of Atg5 or Atg12 resulted in Atg5-Atg12 conjugate formation and suppression of RNA-mediated signaling.
Autophagy is a process of bulk protein degradation in which cytoplasmic components, including organelles, are enclosed in double-membrane structures called autophagosomes and delivered to lysosomes or vacuoles for degradation. ATG12 is the human homolog of a yeast protein involved in autophagy (Mizushima et al., 1998
autophagy-related protein 12
, ubiquitin-like protein ATG12
, ATG12 autophagy related 12 homolog
, Apg12 (autophagy, yeast) homolog
, autophagy-related 12
, potential preautophagosome nucleating protein Atg12