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Regulates autophagy and development of the nervous system. Additionally we are shipping AMBRA1 Proteins (3) and AMBRA1 Kits (1) and many more products for this protein.
Showing 10 out of 95 products:
Human Polyclonal AMBRA1 Primary Antibody for EIA, IHC (p) - ABIN499273
Gozuacik, Kimchi: Autophagy as a cell death and tumor suppressor mechanism. in Oncogene 2004
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Human Polyclonal AMBRA1 Primary Antibody for EIA, IHC (p) - ABIN499271
Kisen, Tessitore, Costelli, Gordon, Schwarze, Baccino, Seglen: Reduced autophagic activity in primary rat hepatocellular carcinoma and ascites hepatoma cells. in Carcinogenesis 1994
Show all 4 references for ABIN499271
Human Polyclonal AMBRA1 Primary Antibody for IHC, ELISA - ABIN1001755
Liang, Jackson, Seaman, Brown, Kempkes, Hibshoosh, Levine: Induction of autophagy and inhibition of tumorigenesis by beclin 1. in Nature 2000
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Human Polyclonal AMBRA1 Primary Antibody for IP, IHC - ABIN347117
Fimia, Stoykova, Romagnoli, Giunta, Di Bartolomeo, Nardacci, Corazzari, Fuoco, Ucar, Schwartz, Gruss, Piacentini, Chowdhury, Cecconi: Ambra1 regulates autophagy and development of the nervous system. in Nature 2007
Show all 3 references for ABIN347117
Mouse (Murine) Polyclonal AMBRA1 Primary Antibody for EIA, IHC (fro) - ABIN1105244
Pagliarini, Wirawan, Romagnoli, Ciccosanti, Lisi, Lippens, Cecconi, Fimia, Vandenabeele, Corazzari, Piacentini: Proteolysis of Ambra1 during apoptosis has a role in the inhibition of the autophagic pro-survival response. in Cell death and differentiation 2012
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Human Polyclonal AMBRA1 Primary Antibody for IHC (p), WB - ABIN388572
Ota, Suzuki, Nishikawa, Otsuki, Sugiyama, Irie, Wakamatsu, Hayashi, Sato, Nagai, Kimura, Makita, Sekine, Obayashi, Nishi, Shibahara, Tanaka, Ishii, Yamamoto, Saito, Kawai, Isono, Nakamura, Nagahari et al.: Complete sequencing and characterization of 21,243 full-length human cDNAs. ... in Nature genetics 2003
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Human Polyclonal AMBRA1 Primary Antibody for IF (p), IHC (p) - ABIN704741
Song, Kou, Zou, Gao, Zeng, Xie: Involvement of autophagy in tri-ortho-cresyl phosphate- induced delayed neuropathy in hens. in Neurochemistry international 2013
Ambra1 knockdown causes severe embryonic malformations.
a de-regulation of c-Myc (show MYC Antibodies) correlates with increased tumorigenesis in AMBRA1-defective systems, thus supporting a role for AMBRA1 as a haploinsufficient tumour suppressor gene.
found Smad2 (show SMAD2 Antibodies) as the major transcriptional regulator of autophagy that targets beclin1 (BECN1 (show BECN1 Antibodies)) gene expression. Smad2 (show SMAD2 Antibodies), but not Smad3 (show SMAD3 Antibodies), acts as a repressor upstream of the BECN1 (show BECN1 Antibodies) promoter region
AMBRA1 interacts with cullin E3 ubiquitin ligases to regulate autophagy dynamics
These results reveal new roles for autophagy-related molecules Atg5 (show ATG5 Antibodies) and Ambra1 during early neuronal differentiation of stem/progenitor cells.
These data identify interaction of Parkin (show PARK2 Antibodies) with Ambra1 as a key mechanism for induction of the final clearance step of Parkin (show PARK2 Antibodies)-mediated mitophagy.
Ambra1 functional deficiency in mouse embryos leads to severe neural tube defects associated with autophagy impairment, accumulation of ubiquitinated proteins, unbalanced cell proliferation and excessive apoptotic cell death
Ambra1 is a crucial regulator of autophagy and apoptosis in ovarian cancer cells subject to cisplatin to maintain the balance between autophagy and apoptosis. Ambra1-targeting inhibition might sensitize ovarian cancer cells to chemotherapy.
An increased expression of AMBRA1 and SQSTM1 (show SQSTM1 Antibodies).
Ambra1 mRNA translocation to P-bodies and translational suppression correlated with increased cell death.
Both AMBRA1 and BECLIN 1 (show BECN1 Antibodies) affect c-Myc (show MYC Antibodies) regulation, but through two different pathways.
Ambra1 is a crucial regulator of autophagy and apoptosis in colorectal cancer cells
A schizophrenia-related risk variant in AMBRA1 (rs11819869) is involved in various aspects of impulsivity, and this involvement occurs on a behavioral as well as an imaging genetics level.
Data suggest that activated autophagy is associated with the progression of pancreatic ductal adenocarcinoma and that the overexpression of autophagy-related proteins Atg5 (show ATG5 Antibodies), Ambra1, beclin-1 (show BECN1 Antibodies), LC3B (show MAP1LC3B Antibodies) and Bif-1 (show ZBTB24 Antibodies) is significantly correlated with poor outcome.
role that Ambra1 in the switch between autophagy and apoptosis
Regulates autophagy and development of the nervous system. Involved in autophagy in controlling protein turnover during neuronal development, and in regulating normal cell survival and proliferation.
autophagy/beclin-1 regulator 1
, activating molecule in BECN1-regulated autophagy protein 1-like
, activating molecule in BECN1-regulated autophagy protein 1
, activating molecule in Beclin1-regulated autophagy
, ischemia related factor NYW-1
, DDB1 and CUL4 associated factor 3
, WD repeat domain 94
, activating molecule in beclin-1-regulated autophagy