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anti-Autophagy/beclin-1 Regulator 1 (AMBRA1) Antibodies

Regulates autophagy and development of the nervous system. Additionally we are shipping AMBRA1 Proteins (3) and AMBRA1 Kits (1) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
AMBRA1 228361 A2AH22
AMBRA1 59319  
AMBRA1 55626 Q9C0C7
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Top anti-AMBRA1 Antibodies at antibodies-online.com

Showing 10 out of 95 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated IHC (p), WB Western blot analysis of AMBRA1 Antibody (N-term) in HepG2 cell line lysates (35 µg/lane). AMBRA1(arrow) was detected using the purified polyclonal antibody (1:60 dilution). Formalin-fixed and paraffin-embedded human breast carcinoma tissue reacted with AMBRA1 antibody (N-term) (ABIN388572), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated IF (p), IHC (p), WB Formalin-fixed and paraffin embedded labeled with rat brain Anti-AMBRA1 Polyclonal Antibody, Unconjugated (ABIN704741) 1:200 followed by conjugation to the secondary antibody and DAB staining Formalin-fixed and paraffin embedded rat lung labeled with Rabbit Anti-AMBRA1 Polyclonal Antibody, Unconjugated 1:200 followed by conjugation to the secondary antibody and DAB staining 100 μL Log in to see 3 to 7 Days
$269.50
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB Immunohistochemistry of Ambra1 in human brain with Ambra1 antibody at 5 μg/ml. Western blot analysis of Ambra1 in 3T3 cell lysate with AP30047PU-N Ambra1 antibody at 1 μg/ml. 0.1 mg Log in to see 6 to 8 Days
$401.50
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB Immunohistochemistry of Ambra1 in human brain with Ambra1 antibody at 5 μg/ml. Western blot analysis of Ambra1 in rat brain tissue lysate with AP30048PU-N Ambra1 antibody at 2 μg/ml. 0.1 mg Log in to see 6 to 8 Days
$401.50
Details
Mouse Rabbit Un-conjugated EIA, IHC (fro), WB Activating molecule in BECN1-regulated autophagy protein 1 (Ambra1) antibody Activating molecule in BECN1-regulated autophagy protein 1 (Ambra1) antibody 0.2 mL Log in to see 6 to 8 Days
$533.50
Details
Human Rabbit Un-conjugated IP, IHC, ELISA, WB 100 μL Log in to see 5 to 6 Days
$320.60
Details
Human Rabbit Un-conjugated IHC (p), WB Anti-AMBRA1 antibody IHC staining of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody  ABIN1099960 dilution 10 ug/ml. 50 μg Log in to see 8 to 10 Days
$451.00
Details
Human Rabbit Un-conjugated IHC, WB 100 μL Log in to see 14 Days
$369.79
Details
Human Rabbit Un-conjugated IHC (p), ELISA, WB Human Kidney (formalin-fixed, paraffin-embedded) stained with AMBRA1 antibody ABIN461918 at 5 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody ABIN481713, alkaline phosphatase-streptavidin and chromogen. Human Heart (formalin-fixed, paraffin-embedded) stained with AMBRA1 antibody ABIN461918 at 5 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody ABIN481713, alkaline phosphatase-streptavidin and chromogen. 50 μg Log in to see 8 to 10 Days
$451.00
Details
Human Rabbit Un-conjugated IHC, ELISA, WB   100 μg Log in to see 15 to 19 Days
$455.07
Details

AMBRA1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-AMBRA1 Antibodies

  1. Human Polyclonal AMBRA1 Primary Antibody for EIA, IHC (p) - ABIN499273 : Gozuacik, Kimchi: Autophagy as a cell death and tumor suppressor mechanism. in Oncogene 2004 (PubMed)
    Show all 4 references for ABIN499273

  2. Human Polyclonal AMBRA1 Primary Antibody for EIA, IHC (p) - ABIN499271 : Kisen, Tessitore, Costelli, Gordon, Schwarze, Baccino, Seglen: Reduced autophagic activity in primary rat hepatocellular carcinoma and ascites hepatoma cells. in Carcinogenesis 1994 (PubMed)
    Show all 4 references for ABIN499271

  3. Human Polyclonal AMBRA1 Primary Antibody for IHC, ELISA - ABIN1001755 : Liang, Jackson, Seaman, Brown, Kempkes, Hibshoosh, Levine: Induction of autophagy and inhibition of tumorigenesis by beclin 1. in Nature 2000 (PubMed)
    Show all 4 references for ABIN1001755

  4. Human Polyclonal AMBRA1 Primary Antibody for IP, IHC - ABIN347117 : Fimia, Stoykova, Romagnoli, Giunta, Di Bartolomeo, Nardacci, Corazzari, Fuoco, Ucar, Schwartz, Gruss, Piacentini, Chowdhury, Cecconi: Ambra1 regulates autophagy and development of the nervous system. in Nature 2007 (PubMed)
    Show all 3 references for ABIN347117

  5. Mouse (Murine) Polyclonal AMBRA1 Primary Antibody for EIA, IHC (fro) - ABIN1105244 : Pagliarini, Wirawan, Romagnoli, Ciccosanti, Lisi, Lippens, Cecconi, Fimia, Vandenabeele, Corazzari, Piacentini: Proteolysis of Ambra1 during apoptosis has a role in the inhibition of the autophagic pro-survival response. in Cell death and differentiation 2012 (PubMed)
    Show all 3 references for ABIN1105244

  6. Human Polyclonal AMBRA1 Primary Antibody for IHC (p), WB - ABIN388572 : Ota, Suzuki, Nishikawa, Otsuki, Sugiyama, Irie, Wakamatsu, Hayashi, Sato, Nagai, Kimura, Makita, Sekine, Obayashi, Nishi, Shibahara, Tanaka, Ishii, Yamamoto, Saito, Kawai, Isono, Nakamura, Nagahari et al.: Complete sequencing and characterization of 21,243 full-length human cDNAs. ... in Nature genetics 2003 (PubMed)
    Show all 2 references for ABIN388572

  7. Human Polyclonal AMBRA1 Primary Antibody for IF (p), IHC (p) - ABIN704741 : Song, Kou, Zou, Gao, Zeng, Xie: Involvement of autophagy in tri-ortho-cresyl phosphate- induced delayed neuropathy in hens. in Neurochemistry international 2013 (PubMed)

More Antibodies against AMBRA1 Interaction Partners

Zebrafish Autophagy/beclin-1 Regulator 1 (AMBRA1) interaction partners

  1. Ambra1 knockdown causes severe embryonic malformations.

Mouse (Murine) Autophagy/beclin-1 Regulator 1 (AMBRA1) interaction partners

  1. a de-regulation of c-Myc (show MYC Antibodies) correlates with increased tumorigenesis in AMBRA1-defective systems, thus supporting a role for AMBRA1 as a haploinsufficient tumour suppressor gene.

  2. found Smad2 (show SMAD2 Antibodies) as the major transcriptional regulator of autophagy that targets beclin1 (BECN1 (show BECN1 Antibodies)) gene expression. Smad2 (show SMAD2 Antibodies), but not Smad3 (show SMAD3 Antibodies), acts as a repressor upstream of the BECN1 (show BECN1 Antibodies) promoter region

  3. AMBRA1 interacts with cullin E3 ubiquitin ligases to regulate autophagy dynamics

  4. These results reveal new roles for autophagy-related molecules Atg5 (show ATG5 Antibodies) and Ambra1 during early neuronal differentiation of stem/progenitor cells.

  5. These data identify interaction of Parkin (show PARK2 Antibodies) with Ambra1 as a key mechanism for induction of the final clearance step of Parkin (show PARK2 Antibodies)-mediated mitophagy.

  6. Ambra1 functional deficiency in mouse embryos leads to severe neural tube defects associated with autophagy impairment, accumulation of ubiquitinated proteins, unbalanced cell proliferation and excessive apoptotic cell death

Human Autophagy/beclin-1 Regulator 1 (AMBRA1) interaction partners

  1. Ambra1 is a crucial regulator of autophagy and apoptosis in ovarian cancer cells subject to cisplatin to maintain the balance between autophagy and apoptosis. Ambra1-targeting inhibition might sensitize ovarian cancer cells to chemotherapy.

  2. An increased expression of AMBRA1 and SQSTM1 (show SQSTM1 Antibodies).

  3. a de-regulation of c-Myc (show MYC Antibodies) correlates with increased tumorigenesis in AMBRA1-defective systems, thus supporting a role for AMBRA1 as a haploinsufficient tumour suppressor gene.

  4. Ambra1 mRNA translocation to P-bodies and translational suppression correlated with increased cell death.

  5. Both AMBRA1 and BECLIN 1 (show BECN1 Antibodies) affect c-Myc (show MYC Antibodies) regulation, but through two different pathways.

  6. AMBRA1 interacts with cullin E3 ubiquitin ligases to regulate autophagy dynamics

  7. Ambra1 is a crucial regulator of autophagy and apoptosis in colorectal cancer cells

  8. A schizophrenia-related risk variant in AMBRA1 (rs11819869) is involved in various aspects of impulsivity, and this involvement occurs on a behavioral as well as an imaging genetics level.

  9. Data suggest that activated autophagy is associated with the progression of pancreatic ductal adenocarcinoma and that the overexpression of autophagy-related proteins Atg5 (show ATG5 Antibodies), Ambra1, beclin-1 (show BECN1 Antibodies), LC3B (show MAP1LC3B Antibodies) and Bif-1 (show ZBTB24 Antibodies) is significantly correlated with poor outcome.

  10. role that Ambra1 in the switch between autophagy and apoptosis

AMBRA1 Antigen Profile

Protein Summary

Regulates autophagy and development of the nervous system. Involved in autophagy in controlling protein turnover during neuronal development, and in regulating normal cell survival and proliferation.

Gene names and symbols associated with AMBRA1

  • autophagy/beclin-1 regulator 1 (AMBRA1) antibody
  • activating molecule in beclin-1-regulated autophagy (LOC100219120) antibody
  • autophagy/beclin-1 regulator 1 (ambra1) antibody
  • autophagy/beclin 1 regulator 1 (Ambra1) antibody
  • 2310079H06Rik antibody
  • A130023A14 antibody
  • AA474864 antibody
  • AV021921 antibody
  • D030051N19Rik antibody
  • DCAF3 antibody
  • mKIAA1736 antibody
  • Nyw1 antibody
  • WDR94 antibody

Protein level used designations for AMBRA1

autophagy/beclin-1 regulator 1 , activating molecule in BECN1-regulated autophagy protein 1-like , activating molecule in BECN1-regulated autophagy protein 1 , activating molecule in Beclin1-regulated autophagy , ischemia related factor NYW-1 , DDB1 and CUL4 associated factor 3 , WD repeat domain 94 , activating molecule in beclin-1-regulated autophagy

GENE ID SPECIES
100050652 Equus caballus
451154 Pan troglodytes
714434 Macaca mulatta
100385379 Callithrix jacchus
100471614 Ailuropoda melanoleuca
100219120 Taeniopygia guttata
100332642 Danio rerio
228361 Mus musculus
59319 Rattus norvegicus
55626 Homo sapiens
423194 Gallus gallus
517263 Bos taurus
483634 Canis lupus familiaris
Selected quality suppliers for anti-AMBRA1 (AMBRA1) Antibodies
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