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Autophagy/beclin-1 Regulator 1 Proteins (AMBRA1)

Regulates autophagy and development of the nervous system. Additionally we are shipping AMBRA1 Antibodies (79) and AMBRA1 Kits (1) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
AMBRA1 228361 A2AH22
Rat AMBRA1 AMBRA1 59319  
AMBRA1 55626 Q9C0C7
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Top AMBRA1 Proteins at antibodies-online.com

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 19 Days
$785.40
Details

AMBRA1 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human ,

More Proteins for Autophagy/beclin-1 Regulator 1 (AMBRA1) Interaction Partners

Zebrafish Autophagy/beclin-1 Regulator 1 (AMBRA1) interaction partners

  1. Ambra1 knockdown causes severe embryonic malformations.

Mouse (Murine) Autophagy/beclin-1 Regulator 1 (AMBRA1) interaction partners

  1. a de-regulation of c-Myc (show MYC Proteins) correlates with increased tumorigenesis in AMBRA1-defective systems, thus supporting a role for AMBRA1 as a haploinsufficient tumour suppressor gene.

  2. found Smad2 (show SMAD2 Proteins) as the major transcriptional regulator of autophagy that targets beclin1 (BECN1 (show BECN1 Proteins)) gene expression. Smad2 (show SMAD2 Proteins), but not Smad3 (show SMAD3 Proteins), acts as a repressor upstream of the BECN1 (show BECN1 Proteins) promoter region

  3. AMBRA1 interacts with cullin E3 ubiquitin ligases to regulate autophagy dynamics

  4. These results reveal new roles for autophagy-related molecules Atg5 (show ATG5 Proteins) and Ambra1 during early neuronal differentiation of stem/progenitor cells.

  5. These data identify interaction of Parkin (show PARK2 Proteins) with Ambra1 as a key mechanism for induction of the final clearance step of Parkin (show PARK2 Proteins)-mediated mitophagy.

  6. Ambra1 functional deficiency in mouse embryos leads to severe neural tube defects associated with autophagy impairment, accumulation of ubiquitinated proteins, unbalanced cell proliferation and excessive apoptotic cell death

Human Autophagy/beclin-1 Regulator 1 (AMBRA1) interaction partners

  1. Ambra1 is a crucial regulator of autophagy and apoptosis in ovarian cancer cells subject to cisplatin to maintain the balance between autophagy and apoptosis. Ambra1-targeting inhibition might sensitize ovarian cancer cells to chemotherapy.

  2. An increased expression of AMBRA1 and SQSTM1 (show SQSTM1 Proteins).

  3. a de-regulation of c-Myc (show MYC Proteins) correlates with increased tumorigenesis in AMBRA1-defective systems, thus supporting a role for AMBRA1 as a haploinsufficient tumour suppressor gene.

  4. Ambra1 mRNA translocation to P-bodies and translational suppression correlated with increased cell death.

  5. Both AMBRA1 and BECLIN 1 (show BECN1 Proteins) affect c-Myc (show MYC Proteins) regulation, but through two different pathways.

  6. AMBRA1 interacts with cullin E3 ubiquitin ligases to regulate autophagy dynamics

  7. Ambra1 is a crucial regulator of autophagy and apoptosis in colorectal cancer cells

  8. A schizophrenia-related risk variant in AMBRA1 (rs11819869) is involved in various aspects of impulsivity, and this involvement occurs on a behavioral as well as an imaging genetics level.

  9. Data suggest that activated autophagy is associated with the progression of pancreatic ductal adenocarcinoma and that the overexpression of autophagy-related proteins Atg5 (show ATG5 Proteins), Ambra1, beclin-1 (show BECN1 Proteins), LC3B (show MAP1LC3B Proteins) and Bif-1 (show ZBTB24 Proteins) is significantly correlated with poor outcome.

  10. role that Ambra1 in the switch between autophagy and apoptosis

AMBRA1 Protein Profile

Protein Summary

Regulates autophagy and development of the nervous system. Involved in autophagy in controlling protein turnover during neuronal development, and in regulating normal cell survival and proliferation.

Gene names and symbols associated with AMBRA1

  • autophagy/beclin-1 regulator 1 (AMBRA1)
  • activating molecule in beclin-1-regulated autophagy (LOC100219120)
  • autophagy/beclin-1 regulator 1 (ambra1)
  • autophagy/beclin 1 regulator 1 (Ambra1)
  • 2310079H06Rik protein
  • A130023A14 protein
  • AA474864 protein
  • AV021921 protein
  • D030051N19Rik protein
  • DCAF3 protein
  • mKIAA1736 protein
  • Nyw1 protein
  • WDR94 protein

Protein level used designations for AMBRA1

autophagy/beclin-1 regulator 1 , activating molecule in BECN1-regulated autophagy protein 1-like , activating molecule in BECN1-regulated autophagy protein 1 , activating molecule in Beclin1-regulated autophagy , ischemia related factor NYW-1 , DDB1 and CUL4 associated factor 3 , WD repeat domain 94 , activating molecule in beclin-1-regulated autophagy

GENE ID SPECIES
100050652 Equus caballus
451154 Pan troglodytes
714434 Macaca mulatta
100385379 Callithrix jacchus
100471614 Ailuropoda melanoleuca
100219120 Taeniopygia guttata
100332642 Danio rerio
228361 Mus musculus
59319 Rattus norvegicus
55626 Homo sapiens
423194 Gallus gallus
517263 Bos taurus
483634 Canis lupus familiaris
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