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Regulates autophagy and development of the nervous system. Additionally we are shipping AMBRA1 Antibodies (96) and AMBRA1 Kits (1) and many more products for this protein.
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Ambra1 knockdown causes severe embryonic malformations.
a de-regulation of c-Myc (show MYC Proteins) correlates with increased tumorigenesis in AMBRA1-defective systems, thus supporting a role for AMBRA1 as a haploinsufficient tumour suppressor gene.
found Smad2 (show SMAD2 Proteins) as the major transcriptional regulator of autophagy that targets beclin1 (BECN1 (show BECN1 Proteins)) gene expression. Smad2 (show SMAD2 Proteins), but not Smad3 (show SMAD3 Proteins), acts as a repressor upstream of the BECN1 (show BECN1 Proteins) promoter region
AMBRA1 interacts with cullin E3 ubiquitin ligases to regulate autophagy dynamics
These results reveal new roles for autophagy-related molecules Atg5 (show ATG5 Proteins) and Ambra1 during early neuronal differentiation of stem/progenitor cells.
These data identify interaction of Parkin (show PARK2 Proteins) with Ambra1 as a key mechanism for induction of the final clearance step of Parkin (show PARK2 Proteins)-mediated mitophagy.
Ambra1 functional deficiency in mouse embryos leads to severe neural tube defects associated with autophagy impairment, accumulation of ubiquitinated proteins, unbalanced cell proliferation and excessive apoptotic cell death
Ambra1 is a crucial regulator of autophagy and apoptosis in ovarian cancer cells subject to cisplatin to maintain the balance between autophagy and apoptosis. Ambra1-targeting inhibition might sensitize ovarian cancer cells to chemotherapy.
An increased expression of AMBRA1 and SQSTM1 (show SQSTM1 Proteins).
Ambra1 mRNA translocation to P-bodies and translational suppression correlated with increased cell death.
Both AMBRA1 and BECLIN 1 (show BECN1 Proteins) affect c-Myc (show MYC Proteins) regulation, but through two different pathways.
Ambra1 is a crucial regulator of autophagy and apoptosis in colorectal cancer cells
A schizophrenia-related risk variant in AMBRA1 (rs11819869) is involved in various aspects of impulsivity, and this involvement occurs on a behavioral as well as an imaging genetics level.
Data suggest that activated autophagy is associated with the progression of pancreatic ductal adenocarcinoma and that the overexpression of autophagy-related proteins Atg5 (show ATG5 Proteins), Ambra1, beclin-1 (show BECN1 Proteins), LC3B (show MAP1LC3B Proteins) and Bif-1 (show ZBTB24 Proteins) is significantly correlated with poor outcome.
role that Ambra1 in the switch between autophagy and apoptosis
Regulates autophagy and development of the nervous system. Involved in autophagy in controlling protein turnover during neuronal development, and in regulating normal cell survival and proliferation.
autophagy/beclin-1 regulator 1
, activating molecule in BECN1-regulated autophagy protein 1-like
, activating molecule in BECN1-regulated autophagy protein 1
, activating molecule in Beclin1-regulated autophagy
, ischemia related factor NYW-1
, DDB1 and CUL4 associated factor 3
, WD repeat domain 94
, activating molecule in beclin-1-regulated autophagy