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Acts as a ventralizing factor during embryogenesis. Additionally we are shipping Axin Interactor, Dorsalization Associated Antibodies (51) and Axin Interactor, Dorsalization Associated Kits (2) and many more products for this protein.
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Human AIDA Protein expressed in Escherichia coli (E. coli) - ABIN1098551
Rui, Xu, Xiong, Cao, Lin, Zhang, Chan, Luo, Han, Lu, Ye, Zhou, Han, Meng, Lin: A beta-catenin-independent dorsalization pathway activated by Axin/JNK signaling and antagonized by aida. in Developmental cell 2007
A dorsalization (show AXIN1 Proteins)pathway that (show MAPK8 Proteins)is exerted by Axin/JNK signali (show AXIN1 Proteins)ng and its inhibitor Aida during vertebrate embryogenesis, is defined.
Aida blocks Axin (show AXIN1 Proteins)-mediated JNK (show MAPK8 Proteins) activation by disrupting Axin (show AXIN1 Proteins) homodimerization. In zebrafish embryos, the dorsalization induced by axin (show AXIN1 Proteins) could be repressed by aida. This activity of aida is conferred by its ability to block Axin (show AXIN1 Proteins)-mediated JNK (show MAPK8 Proteins) activity.
Acts as a ventralizing factor during embryogenesis. Inhibits axin-mediated JNK activation by binding axin and disrupting axin homodimerization. This in turn antagonizes a Wnt/beta-catenin-independent dorsalization pathway activated by AXIN/JNK-signaling (By similarity).
chromosome 1 open reading frame 80
, axin interactor, dorsalization-associated protein
, UPF0491 protein C1orf80 homolog
, axin interaction partner and dorsalization antagonist