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Azurophil granules, specialized lysosomes of the neutrophil, contain at least 10 proteins implicated in the killing of microorganisms. Additionally we are shipping Azurocidin 1 Antibodies (64) and Azurocidin 1 Kits (56) and many more products for this protein.
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Human AZU1 Protein expressed in Human Cells - ABIN2003187
Morgan, Sukiennicki, Pereira, Spitznagel, Guerra, Larrick: Cloning of the cDNA for the serine protease homolog CAP37/azurocidin, a microbicidal and chemotactic protein from human granulocytes. in Journal of immunology (Baltimore, Md. : 1950) 1991
Show all 5 references for ABIN2003187
Human AZU1 Protein expressed in HEK-293 Cells - ABIN2180608
Wasiluk, Skubitz, Gray: Comparison of granule proteins from human polymorphonuclear leukocytes which are bactericidal toward Pseudomonas aeruginosa. in Infection and immunity 1991
Show all 3 references for ABIN2180608
Human AZU1 Protein expressed in Escherichia coli (E. coli) - ABIN2120631
Wang, Liu, Dong, Pan, Ma: Azurocidin-induced inhibition of oxygen metabolism in mitochondria is antagonized by heparin. in Experimental and therapeutic medicine 2014
Neuronal CAP37 may modulate the neuroinflammatory response in Alzheimer disease.
Plasma levels of heparin-binding protein were significantly higher in patients with acute respiratory distress syndrome.
identified a multifunctional bioactive peptide, based on CAP37, that induces cell migration, possesses antibacterial and LPS (show IRF6 Proteins)-binding activity, and is effective at healing infected and noninfected corneal wounds in vivo.
Azurocidin 1 displays antimicrobial activity against E. coli, S. faecalis, and C. albicans.
Low levels of azurocidin in maternal serum in the first trimester were associated with subsequent preterm prelabor rupture of membranes.
AZU1 exhibited high affinity binding to PTX3 (show PITX3 Proteins) in a calcium ion-dependent manner
Heparin-binding protein is elevated in patients with shock from septic and non-septic etiologies.
The TAASC motif in a cyclizised 20-44 amino acid peptide is part of the ligand in HBP responsible for activation of the HBP receptor on monocytes. Monocytes release HBP constitutively in small amounts and more so in the presence of lipopolysaccharide.
Proliferating bile ductules may play a role in the inflammatory response in biliary atresia through expression of CAP37.
group A streptococci induce contact activation and HBP release during skin infection, which likely contribute to the symptoms seen in erysipelas: fever, pain, erythema, and edema
Azurophil granules, specialized lysosomes of the neutrophil, contain at least 10 proteins implicated in the killing of microorganisms. The protein encoded by this gene is an azurophil granule antibiotic protein, with monocyte chemotactic and antibacterial activity. It is also an important multifunctional inflammatory mediator. This encoded protein is a member of the serine protease gene family but it is not a serine proteinase, because the active site serine and histidine residues are replaced. The genes encoding this protein, neutrophil elastase 2, and proteinase 3 are in a cluster located at chromosome 19pter. All 3 genes are expressed coordinately and their protein products are packaged together into azurophil granules during neutrophil differentiation.
, azurocidin 1 (cationic antimicrobial protein 37)
, cationic antimicrobial protein 37
, cationic antimicrobial protein CAP37
, heparin-binding protein
, neutrophil azurocidin
, 60S ribosomal protein L22
, heparin-binding protein HBp15