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BCL11A encodes a C2H2 type zinc-finger protein by its similarity to the mouse Bcl11a/Evi9 protein. Additionally we are shipping BCL11A Kits (6) and BCL11A Proteins (5) and many more products for this protein.
Showing 10 out of 114 products:
Human Monoclonal BCL11A Primary Antibody for WB - ABIN395972
Bailey, Xie, Do, Montpetit, Diaz, Mohan, Keavney, Yusuf, Gerstein, Engert, Anand: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. in Diabetes Care 2010
Show all 5 references for ABIN395972
Human Monoclonal BCL11A Primary Antibody for ICC, IF - ABIN2668245
Liu, Ippolito, Wall, Niu, Probst, Lee, Pulford, Banham, Stockwin, Shaffer, Staudt, Das, Dyer, Tucker: Functional studies of BCL11A: characterization of the conserved BCL11A-XL splice variant and its interaction with BCL6 in nuclear paraspeckles of germinal center B cells. in Molecular cancer 2006
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Human Polyclonal BCL11A Primary Antibody for WB - ABIN653582
Solovieff, Milton, Hartley, Sherva, Sebastiani, Dworkis, Klings, Farrer, Garrett, Ashley-Koch, Telen, Fucharoen, Ha, Li, Chui, Baldwin, Steinberg: Fetal hemoglobin in sickle cell anemia: genome-wide association studies suggest a regulatory region in the 5' olfactory receptor gene cluster. in Blood 2010
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Human Polyclonal BCL11A Primary Antibody for EIA, WB - ABIN950622
Nuinoon, Makarasara, Mushiroda, Setianingsih, Wahidiyat, Sripichai, Kumasaka, Takahashi, Svasti, Munkongdee, Mahasirimongkol, Peerapittayamongkol, Viprakasit, Kamatani, Winichagoon, Kubo, Nakamura, Fucharoen: A genome-wide association identified the common genetic variants influence disease severity in beta0-thalassemia/hemoglobin E. in Human genetics 2010
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Chicken Polyclonal BCL11A Primary Antibody for IHC, WB - ABIN2781048
Uda, Galanello, Sanna, Lettre, Sankaran, Chen, Usala, Busonero, Maschio, Albai, Piras, Sestu, Lai, Dei, Mulas, Crisponi, Naitza, Asunis, Deiana, Nagaraja, Perseu, Satta, Cipollina, Sollaino, Moi, Hirschhorn, Orkin, Abecasis, Schlessinger, Cao: Genome-wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of beta-thalassemia. in Proceedings of the National Academy of Sciences of the United States of America 2008
deletion of Bcl11a alters the regulation of hematopoietic stem cell quiescence, self-renewal, and fate choice
This study showed that the expression of Sema3c (show SEMA3C Antibodies) is increased in migrating Bcl11a-deficient neurons and that Bcl11a is a direct negative regulator of Sema3c (show SEMA3C Antibodies) transcription
The results of this study support a role for CTIP1 on the specification of the Subcerebral Projection Neurons in layer 5 through the repression of TBR1 (show TBR1 Antibodies) and the promotion of CTIP2 (show BCL11B Antibodies) expression.
Data indicate that Myb and BCL11A cooperate with DNMT1 to achieve developmental repression of embryonic and fetal beta-like human transgenic globin genes in the adult erythroid environment.
BCL11A is an essential, lineage-specific factor that regulates plasmacytoid dendritic cell development, supporting a model wherein differentiation into pDCs represents a primed "default" pathway for common dendritic cell progenitors.
Bcl11a controls Flt3 (show FLT3 Antibodies) expression in early hematopoietic progenitors and is required for pDC (show PDC Antibodies) development in vivo.
Immunohistochemical staining of mouse brain showed strong expression of BCL11A in the cortical regions and also in the pyramidal cell layers in the CA1 (show CA1 Antibodies) and CA3 (show CA3 Antibodies) regions of the hippocampus.
data support an important role for the KLF1-BCL11A axis in erythroid maturation and developmental regulation of globin expression
The major B cell isoform, BCL11A-XL, binds the RAG1 (show RAG1 Antibodies) promoter and Erag enhancer to activate RAG1 (show RAG1 Antibodies) and RAG2 (show RAG2 Antibodies) transcription in pre-B cells.
Overexpression of Bcl2 (show BCL2 Antibodies) and Mdm2 (show MDM2 Antibodies), or p53 (show TP53 Antibodies) deficiency, rescues both lethality and proliferative defects in Bcl11a-deficient early B cells.
Extensive genetic analyses have validated BCL11A as a potent repressor of fetal hemoglobin (show HBB Antibodies) level. Studies of BCL11A exemplify how contextual gene regulation may often be the substrate for trait-associated common genetic variation
Association has been found between variants at BCL11A erythroid-specific enhancer and fetal hemoglobin levels among sickle cell disease patients in Cameroon.
These data suggest a possible role for BCL11A expression in acute myeloid leukaemia biology
only HbF inducer efficient in rescuing the ability to differentiate along the erythroid program, even in K562 cell clones expressing high levels of BCL11A-XL, suggesting that BCL11A-XL activity is counteracted by mithramycin.
a successful induction of gamma-globin (show HBG1 Antibodies) includes a reduction in BCL11A, KLF1 (show KLF1 Antibodies) and TAL1 (show TAL1 Antibodies) expression.
this study found that LRF/ZBTB7A (show ZBTB7A Antibodies) transcription factor occupies fetal gamma-globin (show HBG1 Antibodies) genes and maintains the nucleosome density necessary for gamma-globin (show HBG1 Antibodies) gene silencing in adults, and that LRF (show ZBTB7A Antibodies) confers its repressive activity through a NuRD repressor complex independent of the fetal globin repressor BCL11A.
BCL11A has an important role in triple-negative breast cancer and normal mammary epithelial cells
The study compares polymorphism at BCL11A to HBS1L (show HBS1L Antibodies)-MYB (show MYB Antibodies) loci and explains less of the variance in HbF in patients with sickle cell disease in Cameroon.
Common HbF BCL11A enhancer haplotypes in patients with African origin and Arab-Indian sickle cell anemia have similar effects on HbF but they do not explain their differences in HbF.
the study of these rare patients and orthogonal genetic data demonstrates that BCL11A plays a central role in silencing HbF in humans and implicates BCL11A as an important factor for neurodevelopment
This gene encodes a C2H2 type zinc-finger protein by its similarity to the mouse Bcl11a/Evi9 protein. The corresponding mouse gene is a common site of retroviral integration in myeloid leukemia, and may function as a leukemia disease gene, in part, through its interaction with BCL6. During hematopoietic cell differentiation, this gene is down-regulated. It is possibly involved in lymphoma pathogenesis since translocations associated with B-cell malignancies also deregulates its expression. Multiple transcript variants encoding several different isoforms have been found for this gene.
B-cell CLL/lymphoma 11A (zinc finger protein)
, B-cell lymphoma/leukemia 11A
, COUP-TF interacting protein 1
, COUP-TF-interacting protein 1
, ecotropic viral integration site 9 protein
, myeloid leukemia
, B-cell CLL/lymphoma 11A (zinc finger protein) isoform 2
, BCL11A B-cell CLL/lymphoma 11A (zinc finger protein) isoform 1
, C2H2-type zinc finger protein
, ecotropic viral integration site 9 homolog
, ecotropic viral integration site 9 protein homolog
, zinc finger protein 856
, B-cell CLL/lymphoma 11A