You are viewing an incomplete version of our website. Please click to reload the website as full version.

B-Cell CLL/lymphoma 11A (Zinc Finger Protein) Proteins (BCL11A)

BCL11A encodes a C2H2 type zinc-finger protein by its similarity to the mouse Bcl11a/Evi9 protein. Additionally we are shipping BCL11A Antibodies (114) and BCL11A Kits (7) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
BCL11A 14025 Q9QYE3
BCL11A 53335 Q9H165
Rat BCL11A BCL11A 305589  
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online
  • orders@antibodies-online.com

Top BCL11A Proteins at antibodies-online.com

Showing 4 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

BCL11A Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , ,
,

More Proteins for B-Cell CLL/lymphoma 11A (Zinc Finger Protein) (BCL11A) Interaction Partners

Mouse (Murine) B-Cell CLL/lymphoma 11A (Zinc Finger Protein) (BCL11A) interaction partners

  1. deletion of Bcl11a alters the regulation of hematopoietic stem cell quiescence, self-renewal, and fate choice

  2. This study showed that the expression of Sema3c (show SEMA3C Proteins) is increased in migrating Bcl11a-deficient neurons and that Bcl11a is a direct negative regulator of Sema3c (show SEMA3C Proteins) transcription

  3. The results of this study support a role for CTIP1 on the specification of the Subcerebral Projection Neurons in layer 5 through the repression of TBR1 and the promotion of CTIP2 expression.

  4. Data indicate that Myb and BCL11A cooperate with DNMT1 to achieve developmental repression of embryonic and fetal beta-like human transgenic globin genes in the adult erythroid environment.

  5. BCL11A is an essential, lineage-specific factor that regulates plasmacytoid dendritic cell development, supporting a model wherein differentiation into pDCs represents a primed "default" pathway for common dendritic cell progenitors.

  6. Bcl11a controls Flt3 (show FLT3 Proteins) expression in early hematopoietic progenitors and is required for pDC (show PDC Proteins) development in vivo.

  7. Immunohistochemical staining of mouse brain showed strong expression of BCL11A in the cortical regions and also in the pyramidal cell layers in the CA1 (show CA1 Proteins) and CA3 (show CA3 Proteins) regions of the hippocampus.

  8. data support an important role for the KLF1-BCL11A axis in erythroid maturation and developmental regulation of globin expression

  9. The major B cell isoform, BCL11A-XL, binds the RAG1 (show RAG1 Proteins) promoter and Erag enhancer to activate RAG1 (show RAG1 Proteins) and RAG2 (show RAG2 Proteins) transcription in pre-B cells.

  10. Overexpression of Bcl2 (show BCL2 Proteins) and Mdm2 (show MDM2 Proteins), or p53 (show TP53 Proteins) deficiency, rescues both lethality and proliferative defects in Bcl11a-deficient early B cells.

Human B-Cell CLL/lymphoma 11A (Zinc Finger Protein) (BCL11A) interaction partners

  1. Extensive genetic analyses have validated BCL11A as a potent repressor of fetal hemoglobin (show HBB Proteins) level. Studies of BCL11A exemplify how contextual gene regulation may often be the substrate for trait-associated common genetic variation

  2. Association has been found between variants at BCL11A erythroid-specific enhancer and fetal hemoglobin levels among sickle cell disease patients in Cameroon.

  3. These data suggest a possible role for BCL11A expression in acute myeloid leukaemia biology

  4. only HbF inducer efficient in rescuing the ability to differentiate along the erythroid program, even in K562 cell clones expressing high levels of BCL11A-XL, suggesting that BCL11A-XL activity is counteracted by mithramycin.

  5. a successful induction of gamma-globin (show HBG1 Proteins) includes a reduction in BCL11A, KLF1 (show KLF1 Proteins) and TAL1 (show TAL1 Proteins) expression.

  6. this study found that LRF/ZBTB7A (show ZBTB7A Proteins) transcription factor occupies fetal gamma-globin (show HBG1 Proteins) genes and maintains the nucleosome density necessary for gamma-globin (show HBG1 Proteins) gene silencing in adults, and that LRF (show ZBTB7A Proteins) confers its repressive activity through a NuRD repressor complex independent of the fetal globin repressor BCL11A.

  7. BCL11A has an important role in triple-negative breast cancer and normal mammary epithelial cells

  8. The study compares polymorphism at BCL11A to HBS1L (show HBS1L Proteins)-MYB (show MYB Proteins) loci and explains less of the variance in HbF in patients with sickle cell disease in Cameroon.

  9. Common HbF BCL11A enhancer haplotypes in patients with African origin and Arab-Indian sickle cell anemia have similar effects on HbF but they do not explain their differences in HbF.

  10. the study of these rare patients and orthogonal genetic data demonstrates that BCL11A plays a central role in silencing HbF in humans and implicates BCL11A as an important factor for neurodevelopment

BCL11A Protein Profile

Protein Summary

This gene encodes a C2H2 type zinc-finger protein by its similarity to the mouse Bcl11a/Evi9 protein. The corresponding mouse gene is a common site of retroviral integration in myeloid leukemia, and may function as a leukemia disease gene, in part, through its interaction with BCL6. During hematopoietic cell differentiation, this gene is down-regulated. It is possibly involved in lymphoma pathogenesis since translocations associated with B-cell malignancies also deregulates its expression. Multiple transcript variants encoding several different isoforms have been found for this gene.

Gene names and symbols associated with BCL11A

  • B cell CLL/lymphoma 11A (zinc finger protein) (Bcl11a)
  • B-cell CLL/lymphoma 11A (zinc finger protein) (BCL11A)
  • B-cell CLL/lymphoma 11A (zinc finger protein) (bcl11a)
  • B-cell CLL/lymphoma 11A (zinc finger protein) (Bcl11a)
  • B-cell CLL/lymphoma 11Aa (bcl11aa)
  • 2810047E18Rik protein
  • BCL-11A protein
  • bcl11a protein
  • BCL11A-L protein
  • BCL11a-M protein
  • BCL11A-S protein
  • BCL11A-XL protein
  • CTIP1 protein
  • D930021L15Rik protein
  • EVI9 protein
  • Evi9a protein
  • Evi9b protein
  • Evi9c protein
  • HBFQTL5 protein
  • mKIAA1809 protein
  • wu:fi09f10 protein
  • zgc:136898 protein
  • ZNF856 protein

Protein level used designations for BCL11A

B-cell CLL/lymphoma 11A (zinc finger protein) , B-cell lymphoma/leukemia 11A , COUP-TF interacting protein 1 , COUP-TF-interacting protein 1 , EVI-9 , ecotropic viral integration site 9 protein , myeloid leukemia , B-cell CLL/lymphoma 11A (zinc finger protein) isoform 2 , BCL-11A , BCL11A B-cell CLL/lymphoma 11A (zinc finger protein) isoform 1 , C2H2-type zinc finger protein , ecotropic viral integration site 9 homolog , ecotropic viral integration site 9 protein homolog , zinc finger protein 856 , B-cell CLL/lymphoma 11A , bcl11a.1 , fi09f10

GENE ID SPECIES
14025 Mus musculus
53335 Homo sapiens
398877 Xenopus laevis
421199 Gallus gallus
481381 Canis lupus familiaris
538680 Bos taurus
305589 Rattus norvegicus
678650 Danio rerio
Selected quality suppliers for BCL11A Proteins (BCL11A)
Did you look for something else?