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The protein encoded by BCL6 is a zinc finger transcription factor and contains an N-terminal POZ domain. Additionally we are shipping BCL6 Proteins (11) and BCL6 Kits (5) and many more products for this protein.
Showing 10 out of 156 products:
Human Monoclonal BCL6 Primary Antibody for IHC (p), ICS - ABIN967677
Baumjohann, Okada, Ansel: Cutting Edge: Distinct waves of BCL6 expression during T follicular helper cell development. in Journal of immunology (Baltimore, Md. : 1950) 2011
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Human Polyclonal BCL6 Primary Antibody for WB - ABIN656985
Chang, Vlad, DAgati, Liu, Zhang, Witkowski, Torkamani, Stokes, Ho, Cortesini, Suciu-Foca: BCL6 is required for differentiation of Ig-like transcript 3-Fc-induced CD8+ T suppressor cells. in Journal of immunology (Baltimore, Md. : 1950) 2010
Show all 4 references for ABIN656985
Human Monoclonal BCL6 Primary Antibody for IF, WB - ABIN659194
Yang, Huang, Chatterjee, Twait, Fisher: A novel mechanism involving coordinated regulation of nuclear levels and acetylation of NF-YA and Bcl6 activates RGS4 transcription. in The Journal of biological chemistry 2010
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Human Polyclonal BCL6 Primary Antibody for EIA, WB - ABIN950636
Lai, Fatemi, Dhasarathy, Malone, Sobol, Geigerman, Jaye, Mav, Shah, Li, Wade: DNA methylation prevents CTCF-mediated silencing of the oncogene BCL6 in B cell lymphomas. in The Journal of experimental medicine 2010
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Human Polyclonal BCL6 Primary Antibody for EIA, WB - ABIN1449999
Lee, Kim, Sivula, Strittmatter: Nogo receptor antagonism promotes stroke recovery by enhancing axonal plasticity. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2004
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Human Polyclonal BCL6 Primary Antibody for ELISA, WB - ABIN1533156
Ye, Lista, Lo Coco, Knowles, Offit, Chaganti, Dalla-Favera: Alterations of a zinc finger-encoding gene, BCL-6, in diffuse large-cell lymphoma. in Science (New York, N.Y.) 1993
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Human Polyclonal BCL6 Primary Antibody for FACS, IHC (p) - ABIN391554
Saito, Novak, Piovan, Basso, Sumazin, Schneider, Crespo, Shen, Bhagat, Califano, Chadburn, Pasqualucci, Dalla-Favera: BCL6 suppression of BCL2 via Miz1 and its disruption in diffuse large B cell lymphoma. in Proceedings of the National Academy of Sciences of the United States of America 2009
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Human Polyclonal BCL6 Primary Antibody for ELISA, WB - ABIN1532126
Miki, Kawamata, Hirosawa, Aoki: Gene involved in the 3q27 translocation associated with B-cell lymphoma, BCL5, encodes a Krüppel-like zinc-finger protein. in Blood 1994
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BCL6 forms a complex with BCL6 corepressor (BCoR (show BCOR Antibodies)) on the promoters of selected Notch (show NOTCH1 Antibodies) target genes such as enhancer of split related 1.
Bob1 (show POU2AF1 Antibodies) directly binds to and transactivate the Bcl6 promoter during the development of follicular T helper cells .
upon binding to a composite NFAT (show NFATC1 Antibodies)/BCL6 regulatory element within the Ccl2 (show CCL2 Antibodies) promoter, NFATc1 (show NFATC1 Antibodies)/beta proteins release the BCL6-dependent repression of Ccl2 (show CCL2 Antibodies) gene in macrophages.
transferred Bcl6-deficient T cells into wildtype hosts. Bcl6-deficient T cells did not develop into GC Tfh, but they still generated CXCR5 (show CXCR5 Antibodies)+ IFN-gamma (show IFNG Antibodies)+ IL-21 (show IL21 Antibodies)+ IL-10 (show IL10 Antibodies)+ Teff, suggesting that this predominant population is not of the Tfh-lineage
Bcl6 middle domain repressor function is required for T follicular helper cell differentiation and utilizes the corepressor MTA3 (show MTA3 Antibodies).
Data indicate that signal transducer and activator of transcription 3 (Stat3 (show STAT3 Antibodies)) can repress the expression of transcription factor Bcl6 and interleukin-4 (IL-4 (show IL4 Antibodies)) in follicular helper T (TFH) cells.
Enforced expression of BCL6 in EGR2 (show EGR2 Antibodies)/3-deficient CD4 (show CD4 Antibodies) T cells partially restored Tfh differentiation and GC formation in response to virus infection
PRMT7 (show PRMT7 Antibodies) could recruit H4R3me1 and symmetric H4R3me2 to the Bcl6 promoter. These results provide evidence for the important roles played by PRMT7 (show PRMT7 Antibodies) in germinal center formation.
Blimp1 (show PRDM1 Antibodies) (encoded by Prdm1 (show PRDM1 Antibodies)) inhibits T(FH) differentiation by antagonizing Bcl-6. TCF-1 (show HNF1A Antibodies) promoted Bcl-6 expression but repressed Blimp1 (show PRDM1 Antibodies) expression.
Transiently expressing Bcl6 in HSPCs causes mature B-cell lymphomas that lack Bcl6 expression and target-gene repression, are transcriptionally similar to post-GCB cells, and show epigenetic changes that are conserved from HSPCs to mature B-cells.
these data suggest that the Bcl6 BTB domain is a key mediator of the differentiation of Tfh cells.
Studies indicate that germinal centers (GC) B (show NPR2 Antibodies) cells represent the normal counterpart of most B-cell lymphomas, which are often characterized by deregulated B cell lymphoma 6 (BCL6) expression or BCL6-mediated pathways.
Bcl-6 mRNA and protein levels, as well as the frequencies of Bcl-6(+)CD4 (show CD4 Antibodies)(+) cells were significantly increased in polyp tissues compared with normal controls.
Follicular helper T cells differentiation is a multistage process involving BCL6 and other transcription factors, cytokines, and costimulation through ICOS (show CTLA4 Antibodies) and several other molecules. (Review)
These results suggest that STAT6 (show STAT6 Antibodies) plays an important role in regulating Sp1 (show PSG1 Antibodies) and BCL6 through STAT2 (show STAT2 Antibodies) to exert the anti-proliferative effects of type I IFN.
Identified BCL6 to be a target of miR (show MLXIP Antibodies)-10a in patients with Acute Myeloid Leukemia (show BCL11A Antibodies) (AML (show RUNX1 Antibodies)).
Study demonstrates that survivin (show BIRC5 Antibodies) belongs to the Tfh cell phenotype and ensures their optimal function by regulating transcriptional activity of Bcl-6.
BCL6 repression of EP300 (show EP300 Antibodies) in human diffuse large B cell lymphoma cells provides a basis for rational combinatorial therapy.
Taken together, our results demonstrated that miR (show MLXIP Antibodies)-187-3p played a pivotal role on NSCLC through inhibiting cell proliferation, migration, invasion, and promoting apoptosis by targeting oncogenic BCL6.
BCL6 gene expression is plays a role in the pathogenesis of diffuse large B-cell lymphoma.
Non-Hodgkin lymphomas with MYC (show MYC Antibodies)+/BCL2 (show BCL2 Antibodies)+/BCL6- gene rearrangements was more likely to have a non-germinal center cell of origin than MYC (show MYC Antibodies)+/BCL2 (show BCL2 Antibodies)-/BCL6+ and MYC (show MYC Antibodies)+/BCL2 (show BCL2 Antibodies)+/BCL6+ lymphomas.
The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of START-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene.
B-cell CLL/lymphoma 6
, B-cell CLL/lymphoma 6 (zinc finger protein 51)
, B-cell lymphoma 6 protein
, zinc finger protein 51
, B-cell leukemia/lymphoma 5
, B-cell leukemia/lymphoma 6
, B-cell lymphoma 6 protein homolog
, B-cell lymphoma 5 protein
, B-cell lymphoma 6 protein transcript
, cys-his2 zinc finger transcription factor
, lymphoma-associated zinc finger gene on chromosome 3
, protein LAZ-3
, zinc finger and BTB domain-containing protein 27
, zinc finger transcription factor BCL6S