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B-Cell CLL/lymphoma 6 Proteins (BCL6)

The protein encoded by BCL6 is a zinc finger transcription factor and contains an N-terminal POZ domain. Additionally we are shipping BCL6 Antibodies (156) and BCL6 Kits (5) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
BCL6 12053 P41183
BCL6 604 P41182
Rat BCL6 BCL6 303836  
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Top BCL6 Proteins at antibodies-online.com

Showing 9 out of 11 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Human His tag,TRX tag 100 μg Log in to see 16 Days
$272.80
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Human GST tag   10 μg Log in to see 3 to 4 Days
$662.36
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   2 μg Log in to see 6 to 11 Days
$450.00
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   5 applications Log in to see 1 to 2 Days
$312.71
Details
Human Un-conjugated   2 μg Log in to see 6 Days
$391.29
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

BCL6 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , ,
, ,

Top referenced BCL6 Proteins

  1. Human BCL6 Protein expressed in Escherichia coli (E. coli) - ABIN2005031 : Ye, Cattoretti, Shen, Zhang, Hawe, de Waard, Leung, Nouri-Shirazi, Orazi, Chaganti, Rothman, Stall, Pandolfi, Dalla-Favera: The BCL-6 proto-oncogene controls germinal-centre formation and Th2-type inflammation. in Nature genetics 1997 (PubMed)
    Show all 2 references for ABIN2005031

More Proteins for B-Cell CLL/lymphoma 6 (BCL6) Interaction Partners

Xenopus laevis B-Cell CLL/lymphoma 6 (BCL6) interaction partners

  1. BCL6 forms a complex with BCL6 corepressor (BCoR (show BCOR Proteins)) on the promoters of selected Notch (show NOTCH1 Proteins) target genes such as enhancer of split related 1.

Mouse (Murine) B-Cell CLL/lymphoma 6 (BCL6) interaction partners

  1. Bob1 (show POU2AF1 Proteins) directly binds to and transactivate the Bcl6 promoter during the development of follicular T helper cells .

  2. upon binding to a composite NFAT (show NFATC1 Proteins)/BCL6 regulatory element within the Ccl2 (show CCL2 Proteins) promoter, NFATc1 (show NFATC1 Proteins)/beta proteins release the BCL6-dependent repression of Ccl2 (show CCL2 Proteins) gene in macrophages.

  3. transferred Bcl6-deficient T cells into wildtype hosts. Bcl6-deficient T cells did not develop into GC Tfh, but they still generated CXCR5 (show CXCR5 Proteins)+ IFN-gamma (show IFNG Proteins)+ IL-21 (show IL21 Proteins)+ IL-10 (show IL10 Proteins)+ Teff, suggesting that this predominant population is not of the Tfh-lineage

  4. Bcl6 middle domain repressor function is required for T follicular helper cell differentiation and utilizes the corepressor MTA3 (show MTA3 Proteins).

  5. Data indicate that signal transducer and activator of transcription 3 (Stat3 (show STAT3 Proteins)) can repress the expression of transcription factor Bcl6 and interleukin-4 (IL-4 (show IL4 Proteins)) in follicular helper T (TFH) cells.

  6. Enforced expression of BCL6 in EGR2 (show EGR2 Proteins)/3-deficient CD4 (show CD4 Proteins) T cells partially restored Tfh differentiation and GC formation in response to virus infection

  7. PRMT7 (show PRMT7 Proteins) could recruit H4R3me1 and symmetric H4R3me2 to the Bcl6 promoter. These results provide evidence for the important roles played by PRMT7 (show PRMT7 Proteins) in germinal center formation.

  8. Blimp1 (show PRDM1 Proteins) (encoded by Prdm1 (show PRDM1 Proteins)) inhibits T(FH) differentiation by antagonizing Bcl-6. TCF-1 (show HNF1A Proteins) promoted Bcl-6 expression but repressed Blimp1 (show PRDM1 Proteins) expression.

  9. Transiently expressing Bcl6 in HSPCs causes mature B-cell lymphomas that lack Bcl6 expression and target-gene repression, are transcriptionally similar to post-GCB cells, and show epigenetic changes that are conserved from HSPCs to mature B-cells.

  10. these data suggest that the Bcl6 BTB domain is a key mediator of the differentiation of Tfh cells.

Human B-Cell CLL/lymphoma 6 (BCL6) interaction partners

  1. Studies indicate that germinal centers (GC) B (show NPR2 Proteins) cells represent the normal counterpart of most B-cell lymphomas, which are often characterized by deregulated B cell lymphoma 6 (BCL6) expression or BCL6-mediated pathways.

  2. Bcl-6 mRNA and protein levels, as well as the frequencies of Bcl-6(+)CD4 (show CD4 Proteins)(+) cells were significantly increased in polyp tissues compared with normal controls.

  3. Follicular helper T cells differentiation is a multistage process involving BCL6 and other transcription factors, cytokines, and costimulation through ICOS (show CTLA4 Proteins) and several other molecules. (Review)

  4. These results suggest that STAT6 (show STAT6 Proteins) plays an important role in regulating Sp1 (show PSG1 Proteins) and BCL6 through STAT2 (show STAT2 Proteins) to exert the anti-proliferative effects of type I IFN.

  5. Identified BCL6 to be a target of miR (show MLXIP Proteins)-10a in patients with Acute Myeloid Leukemia (show BCL11A Proteins) (AML (show RUNX1 Proteins)).

  6. Study demonstrates that survivin (show BIRC5 Proteins) belongs to the Tfh cell phenotype and ensures their optimal function by regulating transcriptional activity of Bcl-6.

  7. BCL6 repression of EP300 (show EP300 Proteins) in human diffuse large B cell lymphoma cells provides a basis for rational combinatorial therapy.

  8. Taken together, our results demonstrated that miR (show MLXIP Proteins)-187-3p played a pivotal role on NSCLC through inhibiting cell proliferation, migration, invasion, and promoting apoptosis by targeting oncogenic BCL6.

  9. BCL6 gene expression is plays a role in the pathogenesis of diffuse large B-cell lymphoma.

  10. Non-Hodgkin lymphomas with MYC (show MYC Proteins)+/BCL2 (show BCL2 Proteins)+/BCL6- gene rearrangements was more likely to have a non-germinal center cell of origin than MYC (show MYC Proteins)+/BCL2 (show BCL2 Proteins)-/BCL6+ and MYC (show MYC Proteins)+/BCL2 (show BCL2 Proteins)+/BCL6+ lymphomas.

BCL6 Protein Profile

Protein Summary

The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of START-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene.

Gene names and symbols associated with B-Cell CLL/lymphoma 6 Proteins (BCL6)

  • B-cell CLL/lymphoma 6 (bcl6)
  • B-cell CLL/lymphoma 6 (BCL6)
  • B cell leukemia/lymphoma 6 (Bcl6)
  • B-cell CLL/lymphoma 6 (Bcl6)
  • BCL5 protein
  • BCL6A protein
  • LAZ3 protein
  • MGC132260 protein
  • ZBTB27 protein
  • ZNF51 protein

Protein level used designations for B-Cell CLL/lymphoma 6 Proteins (BCL6)

B-cell CLL/lymphoma 6 , B-cell CLL/lymphoma 6 (zinc finger protein 51) , B-cell lymphoma 6 protein , zinc finger protein 51 , B-cell leukemia/lymphoma 5 , B-cell leukemia/lymphoma 6 , B-cell lymphoma 6 protein homolog , B-cell lymphoma 5 protein , B-cell lymphoma 6 protein transcript , BCL-5 , BCL-6 , cys-his2 zinc finger transcription factor , lymphoma-associated zinc finger gene on chromosome 3 , protein LAZ-3 , zinc finger and BTB domain-containing protein 27 , zinc finger transcription factor BCL6S

GENE ID SPECIES
495412 Xenopus laevis
100126063 Xenopus (Silurana) tropicalis
100294564 Pongo abelii
488124 Canis lupus familiaris
12053 Mus musculus
604 Homo sapiens
303836 Rattus norvegicus
100156549 Sus scrofa
539020 Bos taurus
101110557 Ovis aries
100353941 Oryctolagus cuniculus
424912 Gallus gallus
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