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Transcriptional repressor which is required for germinal center formation and antibody affinity maturation.
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Bob1 (show POU2AF1 ELISA Kits) directly binds to and transactivate the Bcl6 promoter during the development of follicular T helper cells .
upon binding to a composite NFAT (show NFATC1 ELISA Kits)/BCL6 regulatory element within the Ccl2 (show CCL2 ELISA Kits) promoter, NFATc1 (show NFATC1 ELISA Kits)/beta proteins release the BCL6-dependent repression of Ccl2 (show CCL2 ELISA Kits) gene in macrophages.
transferred Bcl6-deficient T cells into wildtype hosts. Bcl6-deficient T cells did not develop into GC Tfh, but they still generated CXCR5 (show CXCR5 ELISA Kits)+ IFN-gamma (show IFNG ELISA Kits)+ IL-21 (show IL21 ELISA Kits)+ IL-10 (show IL10 ELISA Kits)+ Teff, suggesting that this predominant population is not of the Tfh-lineage
Bcl6 middle domain repressor function is required for T follicular helper cell differentiation and utilizes the corepressor MTA3 (show MTA3 ELISA Kits).
Data indicate that signal transducer and activator of transcription 3 (Stat3 (show STAT3 ELISA Kits)) can repress the expression of transcription factor Bcl6 and interleukin-4 (IL-4 (show IL4 ELISA Kits)) in follicular helper T (TFH) cells.
Enforced expression of BCL6 in EGR2 (show EGR2 ELISA Kits)/3-deficient CD4 (show CD4 ELISA Kits) T cells partially restored Tfh differentiation and GC formation in response to virus infection
PRMT7 (show PRMT7 ELISA Kits) could recruit H4R3me1 and symmetric H4R3me2 to the Bcl6 promoter. These results provide evidence for the important roles played by PRMT7 (show PRMT7 ELISA Kits) in germinal center formation.
Blimp1 (show PRDM1 ELISA Kits) (encoded by Prdm1 (show PRDM1 ELISA Kits)) inhibits T(FH) differentiation by antagonizing Bcl-6. TCF-1 (show HNF1A ELISA Kits) promoted Bcl-6 expression but repressed Blimp1 (show PRDM1 ELISA Kits) expression.
Transiently expressing Bcl6 in HSPCs causes mature B-cell lymphomas that lack Bcl6 expression and target-gene repression, are transcriptionally similar to post-GCB (show NPR2 ELISA Kits) cells, and show epigenetic changes that are conserved from HSPCs to mature B-cells.
these data suggest that the Bcl6 BTB domain is a key mediator of the differentiation of Tfh cells.
Transcriptional repressor which is required for germinal center formation and antibody affinity maturation. Probably plays an important role in lymphomagenesis (By similarity).
B-cell leukemia/lymphoma 5
, B-cell leukemia/lymphoma 6
, B-cell lymphoma 6 protein homolog
, B-cell CLL/lymphoma 6 (zinc finger protein 51)