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BLNK encodes a cytoplasmic linker or adaptor protein that plays a critical role in B cell development. Additionally we are shipping B-Cell Linker Kits (36) and B-Cell Linker Proteins (15) and many more products for this protein.
Showing 10 out of 209 products:
Human Monoclonal BLNK Primary Antibody for WB - ABIN967596
Chiu, Dalton, Ishiai, Kurosaki, Chan: BLNK: molecular scaffolding through 'cis'-mediated organization of signaling proteins. in The EMBO journal 2002
Show all 5 references for ABIN967596
Human Polyclonal BLNK Primary Antibody for WB - ABIN657356
Davila, Froeling, Tan, Bonnard, Boland, Snippe, Hibberd, Seielstad: New genetic associations detected in a host response study to hepatitis B vaccine. in Genes and immunity 2010
Show all 4 references for ABIN657356
Human Monoclonal BLNK Primary Antibody for ICC, FACS - ABIN968984
Imamura, Oda, Katahira, Bundo, Pike, Ratcliffe, Kitamura: BLNK binds active H-Ras to promote B cell receptor-mediated capping and ERK activation. in The Journal of biological chemistry 2009
Show all 2 references for ABIN968984
Human Polyclonal BLNK Primary Antibody for IHC, ELISA - ABIN1532093
Fu, Turck, Kurosaki, Chan: BLNK: a central linker protein in B cell activation. in Immunity 1998
Show all 2 references for ABIN1532093
Human Polyclonal BLNK Primary Antibody for EIA, WB - ABIN452784
Kamino, Futamura, Nakamura, Kitamura, Kabu, Arakawa: B-cell linker protein prevents aneuploidy by inhibiting cytokinesis. in Cancer science 2008
Show all 2 references for ABIN452784
Human Polyclonal BLNK Primary Antibody for WB - ABIN2782531
Röck, Schneider, Grün, Grützkau, Küppers, Schmitz, Winkels: CD303 (BDCA-2) signals in plasmacytoid dendritic cells via a BCR-like signalosome involving Syk, Slp65 and PLCgamma2. in European journal of immunology 2007
Authors demonstrate leukemogenicity of PAX5 (show PAX5 Antibodies)-PML (show PML Antibodies) by introducing it into normal mouse pro-B cells; B-cell linker protein (Blnk) is repressed by PAX5 (show PAX5 Antibodies)-PML (show PML Antibodies) in leukemia cells; enforced expression of Blnk increases survival despite introduction of PAX5 (show PAX5 Antibodies)-PML (show PML Antibodies).
B-cell linker protein expression contributes to controlling allergic and autoimmune diseases by mediating IL-10 (show IL10 Antibodies) production in regulatory B cells.
Tumor suppressor BLNK is a target of transcriptional activation by PU.1 and Spi-B (show SPIB Antibodies) in the B cell lineage.
a novel negative feedback regulation of BCR (show BCR Antibodies) signaling by HPK1 (show MAP4K1 Antibodies)-mediated phosphorylation, ubiquitination, and subsequent degradation of the activated BLNK
CMTM7 (show CMTM7 Antibodies) functions to link sIgM and BLNK in the plasma membrane.
Live cell imaging and co-immunoprecipitation experiments confirmed that both SLP65 and CIN85 (show SH3KBP1 Antibodies) are both required for the onset and progression phases of B-cell antigen receptor signal transduction.
malignant transformation of Btk (show BTK Antibodies)/Slp65 double-deficient pre-B cells is independent of deregulated V(D)J recombination activity.
Swip-1 (show WSB1 Antibodies) provides a membrane scaffold that is required for the Syk (show SYK Antibodies)-, SLP-65-, and PLCgamma2 (show PLCG2 Antibodies)-dependent BCR (show BCR Antibodies)-induced calcium flux.
malignant transformation of Slp65(-/-) pre-B cells involves disruption of the p19(Arf (show CDKN2A Antibodies))-Mdm2 (show MDM2 Antibodies)-p53 tumor suppressor (show TP53 Antibodies) pathway
The direct recruitment of BLNK to immunoglobulin alpha couples the B-cell antigen receptor to distal signaling pathways
vesicular signaling scaffolds are required for B cell activation indicates that vesicles may deliver preassembled signaling cargo to sites of BCR (show BCR Antibodies) activation.
early Ca(2 (show CA2 Antibodies)+) fluxing provides feed-forward signal amplification by promoting anchoring of the PLCgamma2 (show PLCG2 Antibodies) C2 domain to phospho-SLP65.
up-regulation of BLNK is associated with RUNX1 (show RUNX1 Antibodies) mutations in cytogenetically normal acute myeloid leukemia (show BCL11A Antibodies).
16 of the 34 childhood pre-B acute lymphoblastic leukaemia samples that were tested showed a complete loss or drastic reduction of SLP-65 expression
The BLNK protein is present in the majority of mediastinal B cell lymphomas.
In B cells SLP-65 exists in a 180 kDa complex as well as in monomeric form.
V(H) gene rearrangement represents a frequent feature in B-lymphoid malignancy, which can be attributed to SLP65 deficiency in many cases.
Syk (show SYK Antibodies) is required to link phosphorylated SLP-65 to Ca(2 (show CA2 Antibodies)+) mobilization.
Plasmacytoid dendritic cells express a signalosome consisting of Lyn (show LYN Antibodies), Syk (show SYK Antibodies), Btk (show BTK Antibodies), Slp65 (Blnk) and PLCgamma2 (show PLCG2 Antibodies). Triggering CD303 leads to tyrosine phosphorylation of Syk (show SYK Antibodies), Slp65, PLCgamma2 (show PLCG2 Antibodies) & cytoskeletal proteins.
This gene encodes a cytoplasmic linker or adaptor protein that plays a critical role in B cell development. This protein bridges B cell receptor-associated kinase activation with downstream signaling pathways, thereby affecting various biological functions. The phosphorylation of five tyrosine residues is necessary for this protein to nucleate distinct signaling effectors following B cell receptor activation. Mutations in this gene cause hypoglobulinemia and absent B cells, a disease in which the pro- to pre-B-cell transition is developmentally blocked. Deficiency in this protein has also been shown in some cases of pre-B acute lymphoblastic leukemia. Alternatively spliced transcript variants have been found for this gene.
, B-cell linker protein
, b-cell linker protein-like
, B-cell adapter containing a SH2 domain protein
, B-cell adapter containing a Src homology 2 domain protein
, cytoplasmic adapter protein
, lymphocyte antigen 57
, src homology 2 domain-containing leukocyte protein of 65 kDa
, B cell adaptor containing SH2 domain
, B cell linker protein
, B-cell activation
, Src homology 2 domain-containing leukocyte protein of 65 kDa
, Src homology [SH2] domain-containing leukocyte protein of 65 kD
, B cell linker protein BLNK
, B-cell adapter SH2 domain-containing protein