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B-Cell Linker Proteins (BLNK)

BLNK encodes a cytoplasmic linker or adaptor protein that plays a critical role in B cell development. Additionally we are shipping B-Cell Linker Antibodies (195) and B-Cell Linker Kits (44) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
BLNK 17060 Q9QUN3
BLNK 29760 Q8WV28
BLNK 499356 Q4KM52
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Top B-Cell Linker Proteins at antibodies-online.com

Showing 10 out of 14 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Human Cells Human His tag 50 μg Log in to see 16 Days
$382.80
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 7 to 8 Days
$319.00
Details
HOST_Escherichia coli (E. coli) Human His tag,T7 tag 100 μg Log in to see 11 to 13 Days
$792.00
Details
HOST_Escherichia coli (E. coli) Human His tag   50 μg Log in to see 5 Days
$522.50
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$3,285.33
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 3 to 4 Days
$364.64
Details
Human Un-conjugated   5 μg Log in to see 6 Days
$168.54
Details

BLNK Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , ,
, ,
Rat (Rattus)

Top referenced B-Cell Linker Proteins

  1. Human BLNK Protein expressed in Human Cells - ABIN2005308 : Fu, Turck, Kurosaki, Chan: BLNK: a central linker protein in B cell activation. in Immunity 1998 (PubMed)
    Show all 4 references for ABIN2005308

  2. Human BLNK Protein expressed in Escherichia coli (E. coli) - ABIN667353 : Kurosaki: Molecular mechanisms in B cell antigen receptor signaling. in Current opinion in immunology 1997 (PubMed)
    Show all 2 references for ABIN667353

More Proteins for B-Cell Linker (BLNK) Interaction Partners

Mouse (Murine) B-Cell Linker (BLNK) interaction partners

  1. Authors demonstrate leukemogenicity of PAX5 (show PAX5 Proteins)-PML (show PML Proteins) by introducing it into normal mouse pro-B cells; B-cell linker protein (Blnk) is repressed by PAX5 (show PAX5 Proteins)-PML (show PML Proteins) in leukemia cells; enforced expression of Blnk increases survival despite introduction of PAX5 (show PAX5 Proteins)-PML (show PML Proteins).

  2. B-cell linker protein expression contributes to controlling allergic and autoimmune diseases by mediating IL-10 (show IL10 Proteins) production in regulatory B cells.

  3. Tumor suppressor BLNK is a target of transcriptional activation by PU.1 and Spi-B (show SPIB Proteins) in the B cell lineage.

  4. a novel negative feedback regulation of BCR (show BCR Proteins) signaling by HPK1 (show MAP4K1 Proteins)-mediated phosphorylation, ubiquitination, and subsequent degradation of the activated BLNK

  5. CMTM7 (show CMTM7 Proteins) functions to link sIgM and BLNK in the plasma membrane.

  6. Live cell imaging and co-immunoprecipitation experiments confirmed that both SLP65 and CIN85 (show SH3KBP1 Proteins) are both required for the onset and progression phases of B-cell antigen receptor signal transduction.

  7. malignant transformation of Btk (show BTK Proteins)/Slp65 double-deficient pre-B cells is independent of deregulated V(D)J recombination activity.

  8. Swip-1 (show WSB1 Proteins) provides a membrane scaffold that is required for the Syk (show SYK Proteins)-, SLP-65-, and PLCgamma2 (show PLCG2 Proteins)-dependent BCR (show BCR Proteins)-induced calcium flux.

  9. malignant transformation of Slp65(-/-) pre-B cells involves disruption of the p19(Arf)-Mdm2-p53 tumor suppressor pathway

  10. The direct recruitment of BLNK to immunoglobulin alpha couples the B-cell antigen receptor to distal signaling pathways

Human B-Cell Linker (BLNK) interaction partners

  1. vesicular signaling scaffolds are required for B cell activation indicates that vesicles may deliver preassembled signaling cargo to sites of BCR (show BCR Proteins) activation.

  2. early Ca(2 (show CA2 Proteins)+) fluxing provides feed-forward signal amplification by promoting anchoring of the PLCgamma2 (show PLCG2 Proteins) C2 domain to phospho-SLP65.

  3. up-regulation of BLNK is associated with RUNX1 (show RUNX1 Proteins) mutations in cytogenetically normal acute myeloid leukemia (show BCL11A Proteins).

  4. Live cell imaging and co-immunoprecipitation experiments confirmed that both SLP65 and CIN85 (show SH3KBP1 Proteins) are both required for the onset and progression phases of B-cell antigen receptor signal transduction.

  5. 16 of the 34 childhood pre-B acute lymphoblastic leukaemia samples that were tested showed a complete loss or drastic reduction of SLP-65 expression

  6. The BLNK protein is present in the majority of mediastinal B cell lymphomas.

  7. In B cells SLP-65 exists in a 180 kDa complex as well as in monomeric form.

  8. V(H) gene rearrangement represents a frequent feature in B-lymphoid malignancy, which can be attributed to SLP65 deficiency in many cases.

  9. Syk (show SYK Proteins) is required to link phosphorylated SLP-65 to Ca(2 (show CA2 Proteins)+) mobilization.

  10. Plasmacytoid dendritic cells express a signalosome consisting of Lyn (show LYN Proteins), Syk (show SYK Proteins), Btk (show BTK Proteins), Slp65 (Blnk) and PLCgamma2 (show PLCG2 Proteins). Triggering CD303 leads to tyrosine phosphorylation of Syk (show SYK Proteins), Slp65, PLCgamma2 (show PLCG2 Proteins) & cytoskeletal proteins.

B-Cell Linker (BLNK) Protein Profile

Protein Summary

This gene encodes a cytoplasmic linker or adaptor protein that plays a critical role in B cell development. This protein bridges B cell receptor-associated kinase activation with downstream signaling pathways, thereby affecting various biological functions. The phosphorylation of five tyrosine residues is necessary for this protein to nucleate distinct signaling effectors following B cell receptor activation. Mutations in this gene cause hypoglobulinemia and absent B cells, a disease in which the pro- to pre-B-cell transition is developmentally blocked. Deficiency in this protein has also been shown in some cases of pre-B acute lymphoblastic leukemia. Alternatively spliced transcript variants have been found for this gene.

Gene names and symbols associated with B-Cell Linker Proteins (BLNK)

  • B-cell linker (BLNK)
  • B-cell linker (blnk)
  • B-cell linker protein (blnk)
  • B cell linker (Blnk)
  • B-cell linker (Blnk)
  • B-cell linker-like (LOC100354716)
  • AGM4 protein
  • BASH protein
  • bca protein
  • blnk protein
  • BLNK-S protein
  • Ly-57 protein
  • LY57 protein
  • Lyw-57 protein
  • MGC147045 protein
  • SLP-65 protein
  • SLP65 protein

Protein level used designations for B-Cell Linker Proteins (BLNK)

B-cell linker , B-cell linker protein , b-cell linker protein-like , B-cell adapter containing a SH2 domain protein , B-cell adapter containing a Src homology 2 domain protein , cytoplasmic adapter protein , lymphocyte antigen 57 , src homology 2 domain-containing leukocyte protein of 65 kDa , B cell adaptor containing SH2 domain , B cell linker protein , B-cell activation , Src homology 2 domain-containing leukocyte protein of 65 kDa , Src homology [SH2] domain-containing leukocyte protein of 65 kD , B cell linker protein BLNK , B-cell adapter SH2 domain-containing protein , SLP-65

GENE ID SPECIES
100070841 Equus caballus
405764 Danio rerio
450641 Pan troglodytes
548350 Xenopus (Silurana) tropicalis
704363 Macaca mulatta
100306798 Salmo salar
100456635 Pongo abelii
100481331 Ailuropoda melanoleuca
100593492 Nomascus leucogenys
17060 Mus musculus
29760 Homo sapiens
395733 Gallus gallus
499356 Rattus norvegicus
486814 Canis lupus familiaris
100152350 Sus scrofa
510393 Bos taurus
100712978 Cavia porcellus
101111241 Ovis aries
100354716 Oryctolagus cuniculus
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