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The protein encoded by BANK1 is a B-cell-specific scaffold protein that functions in B-cell receptor-induced calcium mobilization from intracellular stores. Additionally we are shipping BANK1 Antibodies (27) and many more products for this protein.
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The pre-B-cell receptor (pre-BCR (show BCR Proteins)) signaling molecules BLNK (show BLNK Proteins), BTK (show BTK Proteins) and BANK1 were positively regulated by the ZFP521 gene, leading to enhancement of the pre-BCR (show BCR Proteins) signaling pathway.
Following CpG stimulation of B-cells, BANK1 loss reduced p38 (show CRK Proteins) phosphorylation (but not ERK (show EPHB2 Proteins) or JNK (show MAPK8 Proteins)), IL-6 (show IL6 Proteins) secretion, & MNK1 (show MKNK1 Proteins)/2 and eIF4E (show EIF4E Proteins) phosphorylation. It had no effect on IL-6 (show IL6 Proteins) mRNA stability. BANK1 does not affect release of eIF4E (show EIF4E Proteins) by phospho-4E-BP1 (show EIF4EBP1 Proteins).
BANK attenuates CD40 (show CD40 Proteins)-mediated Akt (show AKT1 Proteins) activation, thereby preventing hyperactive B cell responses.
This meta-analysis demonstrates that BANK1 rs10516487, rs3733197, and rs17266594 polymorphisms are associated with susceptibility to autoimmune diseases.
Confirm the association of rs548234/ATG5, rs2736340/BLK and rs10516487/BANK1 with systemic lupus erythematosus in Chinese Han and reinforced our hypothesis of their epistasis effect in regulating B-cell signaling in SLE.
The results of this study suggesting a mechanism for the involvement of BANK1 in the BOLD response to working memory
Single-nucleotide polymorphism in BANK1 gene is associated with sclerotic graft-versus-host disease.
The SLE susceptibility variants in the BANK1 gene may contribute to lupus by altering B cell signaling, increasing FOXO1 (show FOXO1 Proteins) levels, and enhancing memory B cell development
The systemic lupus erythematosus variant Ala71Thr of BLK severely decreases protein abundance and binding to BANK1 through impairment of the SH3 domain function.
Data show that single-nucleotide polymorphism rs3733197 located in the coding region of BANK1 (B-cell scaffold protein with ankyrin repeats 1) was significantly associated with serum LDL cholesterols.
Authors identified a novel balanced reciprocal translocation, t(4;14)(q24;q32.) Sequence analysis identified the partner gene as BANK1.
Our study confirms evidence for epistasis between BLK (show BLK Proteins) and BANK1 in systemic lupus erythematosis from a Chinese population for the first time.
Our findings suggest the existence of association between BANK1 gene and autoimmune thyroid diseases
The protein encoded by this gene is a B-cell-specific scaffold protein that functions in B-cell receptor-induced calcium mobilization from intracellular stores. This protein can also promote Lyn-mediated tyrosine phosphorylation of inositol 1,4,5-trisphosphate receptors. Polymorphisms in this gene are associated with susceptibility to systemic lupus erythematosus. Alternative splicing results in multiple transcript variants.
B-cell scaffold protein with ankyrin repeats
, B-cell scaffold protein with ankyrin repeats 1
, B-cell scaffold protein with ankyrin repeats 1 delta 2 transcript
, B-cell scaffold protein with ankyrin repeats-like
, b-cell scaffold protein with ankyrin repeats-like