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BCL2-Associated Athanogene 2 Proteins (BAG2)

BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. Additionally we are shipping BAG2 Antibodies (75) and BAG2 Kits (3) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
BAG2 9532 O95816
BAG2 213539 Q91YN9
Rat BAG2 BAG2 690038  
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Top BAG2 Proteins at antibodies-online.com

Showing 9 out of 13 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 7 to 8 Days
$319.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$2,517.17
Details
Yeast Arabidopsis thaliana His tag   1 mg Log in to see 56 to 66 Days
$2,750.00
Details
HOST_Escherichia coli (E. coli) Human His tag   50 μg Log in to see 5 Days
$522.50
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 3 to 4 Days
$364.64
Details
Human Un-conjugated   5 μg Log in to see 6 Days
$168.54
Details

BAG2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

Top referenced BAG2 Proteins

  1. Human BAG2 Protein expressed in Escherichia coli (E. coli) - ABIN667379 : Arndt, Daniel, Nastainczyk, Alberti, Höhfeld: BAG-2 acts as an inhibitor of the chaperone-associated ubiquitin ligase CHIP. in Molecular biology of the cell 2005 (PubMed)
    Show all 2 references for ABIN667379

More Proteins for BCL2-Associated Athanogene 2 (BAG2) Interaction Partners

Human BCL2-Associated Athanogene 2 (BAG2) interaction partners

  1. NF-kappaB (show NFKB1 Proteins)-mediated modulation of BAG2 expression regulates the shift between the neurotrophic and neurotoxic effects of Abeta1-42.

  2. Thus, BAG2 promotes mutant p53 (show TP53 Proteins) accumulation and gain-of-function in tumor growth, metastasis and chemoresistance.

  3. This study showed that BAG2 (Bcl-2 (show BCL2 Proteins) associated athanogene family protein 2) and BAG5 (show BAG5 Proteins) (Bcl-2 (show BCL2 Proteins)-associated athanogene family protein 5 (show CAPS Proteins)) stabilise pathogenic ataxin3-80Q by inhibiting its ubiquitination

  4. we measured the binding of human Hsp72 (HSPA1A (show HSPA1A Proteins)) to BAG1 (show BAG1 Proteins), BAG2, BAG3 (show BAG3 Proteins), and the unrelated NEF Hsp105 (show HSPH1 Proteins). These studies revealed a clear hierarchy of affinities: BAG3 (show BAG3 Proteins) > BAG1 (show BAG1 Proteins) > Hsp105 (show HSPH1 Proteins) >> BAG2.

  5. this data correlate BAG2 to PINK1 (show PINK1 Proteins) for the first time, strengthening the important role of BAG2 in Parkinson disease -related neurodegeneration.

  6. BAG2 was directly phosphorylated at serine 20 in vitro by MAPKAPK2 (show MAPKAPK2 Proteins) and MAPKAP2 is also required for phosphorylation of BAG2 in vivo.

  7. BAG2 binds to the carboxyl terminus of Hsp70-interacting protein (show HSPBP1 Proteins) (CHIP) and provides a cochaperone-dependent regulatory mechanism for preventing unregulated ubiquitylation of misfolded proteins by CHIP

  8. The activity of BAG-2 resembles that of the previously characterized Hsc70 (show HSPA8 Proteins) cochaperone and CHIP inhibitor HspBP1 (show HSPBP1 Proteins).

Mouse (Murine) BCL2-Associated Athanogene 2 (BAG2) interaction partners

  1. findings support the notion that BAG2 is an upstream regulator of the PINK1 (show PINK1 Proteins)/PARKIN (show PARK2 Proteins) signaling pathway.

  2. Native Bag2-NTD crystals diffracted to 2.27 A resolution and belonged to space group P2(1)2(1)2(1), with unit-cell parameters a = 75.5, b = 84.7, c = 114.1 A

  3. Free and Hsc70 (show HSPA8 Proteins)-bound crystal structures of Bag2-BNB show its dimeric structure, in which a flanking linker helix and loop bind to Hsc70 (show HSPA8 Proteins) to promote nucleotide exchange.

BAG2 Protein Profile

Protein Summary

BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The predicted BAG2 protein contains 211 amino acids. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner.

Gene names and symbols associated with BAG2

  • BCL2-associated athanogene 2 (bag2)
  • BCL2-associated athanogene 2 (BAG2)
  • BCL2-associated athanogene 2 (LOC100346462)
  • BCL-2-associated athanogene 2 (BAG2)
  • BCL2-associated athanogene 2 (Bag2)
  • Bcl2-associated athanogene 2 (Bag2)
  • 2610042A13Rik protein
  • ATBAG2 protein
  • BAG-2 protein
  • BAG2 protein
  • BC016230 protein
  • BCL-2-associated athanogene 2 protein
  • dJ417I1.2 protein
  • MGC89300 protein
  • MTG10.13 protein
  • MTG10_13 protein
  • zgc:64195 protein

Protein level used designations for BAG2

BCL2-associated athanogene 2 , BAG family molecular chaperone regulator 2 , putative BCL2-associated athanogene 2 , BAG-family molecular chaperone regulator-2 , bcl-2-associated athanogene 2 , dJ417I1.2 (BAG-family molecular chaperone regulator 2) , BAG-2

GENE ID SPECIES
448388 Xenopus (Silurana) tropicalis
462797 Pan troglodytes
100346462 Oryctolagus cuniculus
100190641 Taeniopygia guttata
836330 Arabidopsis thaliana
9532 Homo sapiens
393975 Danio rerio
421880 Gallus gallus
610506 Canis lupus familiaris
506107 Bos taurus
213539 Mus musculus
690038 Rattus norvegicus
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