BCL2-Associated Athanogene 2 (BAG2) ELISA Kits

BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. Additionally we are shipping BAG2 Antibodies (90) and BAG2 Proteins (11) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Human BAG2 BAG2 9532 O95816
Anti-Mouse BAG2 BAG2 213539 Q91YN9
Anti-Rat BAG2 BAG2 690038  
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More ELISA Kits for BAG2 Interaction Partners

Human BCL2-Associated Athanogene 2 (BAG2) interaction partners

  1. A comprehensive review of the structure, functions, and protein interactions of BAG2

  2. Data show that BAG2 Inhibits CHIP-Mediated HSP72 (show HSPA1A ELISA Kits) ubiquitination in aged cells.

  3. repression of BAG2 expression or BAG2 activity by cold-sensitive pathways, as modeled in undifferentiated and differentiated cells, respectively, may be a causal factor in the accumulation of cytotoxic hyperphosphorylated tau protein.

  4. NF-kappaB (show NFKB1 ELISA Kits)-mediated modulation of BAG2 expression regulates the shift between the neurotrophic and neurotoxic effects of Abeta1-42.

  5. Thus, BAG2 promotes mutant p53 (show TP53 ELISA Kits) accumulation and gain-of-function in tumor growth, metastasis and chemoresistance.

  6. This study showed that BAG2 (Bcl-2 (show BCL2 ELISA Kits) associated athanogene family protein 2) and BAG5 (show BAG5 ELISA Kits) (Bcl-2 (show BCL2 ELISA Kits)-associated athanogene family protein 5 (show CAPS ELISA Kits)) stabilise pathogenic ataxin3-80Q by inhibiting its ubiquitination

  7. we measured the binding of human Hsp72 (HSPA1A (show HSPA1A ELISA Kits)) to BAG1 (show BAG1 ELISA Kits), BAG2, BAG3 (show BAG3 ELISA Kits), and the unrelated NEF Hsp105 (show HSPH1 ELISA Kits). These studies revealed a clear hierarchy of affinities: BAG3 (show BAG3 ELISA Kits) > BAG1 (show BAG1 ELISA Kits) > Hsp105 (show HSPH1 ELISA Kits) >> BAG2.

  8. this data correlate BAG2 to PINK1 for the first time, strengthening the important role of BAG2 in Parkinson disease -related neurodegeneration.

  9. BAG2 was directly phosphorylated at serine 20 in vitro by MAPKAPK2 (show MAPKAPK2 ELISA Kits) and MAPKAP2 is also required for phosphorylation of BAG2 in vivo.

  10. BAG2 binds to the carboxyl terminus of Hsp70-interacting protein (CHIP) and provides a cochaperone-dependent regulatory mechanism for preventing unregulated ubiquitylation of misfolded proteins by CHIP

Mouse (Murine) BCL2-Associated Athanogene 2 (BAG2) interaction partners

  1. findings support the notion that BAG2 is an upstream regulator of the PINK1/PARKIN (show PARK2 ELISA Kits) signaling pathway.

  2. Native Bag2-NTD crystals diffracted to 2.27 A resolution and belonged to space group P2(1)2(1)2(1), with unit-cell parameters a = 75.5, b = 84.7, c = 114.1 A

  3. Free and Hsc70 (show HSPA8 ELISA Kits)-bound crystal structures of Bag2-BNB show its dimeric structure, in which a flanking linker helix and loop bind to Hsc70 (show HSPA8 ELISA Kits) to promote nucleotide exchange.

BAG2 Antigen Profile

Antigen Summary

BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The predicted BAG2 protein contains 211 amino acids. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner.

Gene names and symbols associated with BAG2

  • BCL2 associated athanogene 2 (bag2) antibody
  • BCL2 associated athanogene 2 (BAG2) antibody
  • BCL-2-associated athanogene 2 (BAG2) antibody
  • BCL2-associated athanogene 2 (bag2) antibody
  • BCL2-associated athanogene 2 (Bag2) antibody
  • Bcl2-associated athanogene 2 (Bag2) antibody
  • 2610042A13Rik antibody
  • ATBAG2 antibody
  • BAG-2 antibody
  • BAG2 antibody
  • BC016230 antibody
  • BCL-2-associated athanogene 2 antibody
  • dJ417I1.2 antibody
  • MGC89300 antibody
  • MTG10.13 antibody
  • MTG10_13 antibody
  • zgc:64195 antibody

Protein level used designations for BAG2

BCL2-associated athanogene 2 , BAG family molecular chaperone regulator 2 , putative BCL2-associated athanogene 2 , BAG-family molecular chaperone regulator-2 , bcl-2-associated athanogene 2 , dJ417I1.2 (BAG-family molecular chaperone regulator 2) , BAG-2

448388 Xenopus (Silurana) tropicalis
462797 Pan troglodytes
100346462 Oryctolagus cuniculus
100190641 Taeniopygia guttata
836330 Arabidopsis thaliana
9532 Homo sapiens
393975 Danio rerio
421880 Gallus gallus
610506 Canis lupus familiaris
506107 Bos taurus
213539 Mus musculus
690038 Rattus norvegicus
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