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BCL2-Associated Athanogene 3 Proteins (BAG3)

BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. Additionally we are shipping BAG3 Antibodies (121) and BAG3 Kits (12) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
BAG3 9531 O95817
BAG3 29810 Q9JLV1
Rat BAG3 BAG3 293524  
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Top BAG3 Proteins at antibodies-online.com

Showing 10 out of 14 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Human His tag 50 μg Log in to see 7 to 8 Days
$407.00
Details
HOST_Escherichia coli (E. coli) Mouse His-SUMO Tag 50 μg Log in to see 21 to 26 Days
$341.00
Details
Yeast Mouse His tag 50 μg Log in to see 31 to 36 Days
$341.00
Details
Yeast Arabidopsis thaliana His tag   1 mg Log in to see 56 to 66 Days
$2,806.83
Details
HOST_Escherichia coli (E. coli) Human His tag   1 mg Log in to see 3 to 4 Days
$5,769.50
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 3 to 4 Days
$467.86
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

BAG3 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
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Mouse (Murine) ,
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Top referenced BAG3 Proteins

  1. Human BAG3 Protein expressed in Escherichia coli (E. coli) - ABIN667755 : Kyratsous, Silverstein: The co-chaperone BAG3 regulates Herpes Simplex Virus replication. in Proceedings of the National Academy of Sciences of the United States of America 2008 (PubMed)
    Show all 2 references for ABIN667755

  2. Human BAG3 Protein expressed in Wheat germ - ABIN1346366 : Chen, Yang, Cheng, Tu, Guo, Le, Xiong, Mo, Li, Jeong, Jiang, Blackshaw, Bi, Zhu, Tao, Ge: Bcl2-associated athanogene 3 interactome analysis reveals a new role in modulating proteasome activity. in Molecular & cellular proteomics : MCP 2013 (PubMed)

More Proteins for BCL2-Associated Athanogene 3 (BAG3) Interaction Partners

Zebrafish BCL2-Associated Athanogene 3 (BAG3) interaction partners

  1. findings showed that the P209L mutation causes BAG3 to aggregate; proposed that the gradual loss of available BAG3(wt) and BAG3(P209L) proteins results in insufficiency leading to myofibrillar disintegration

Human BCL2-Associated Athanogene 3 (BAG3) interaction partners

  1. The present study, for the first time, examined the expression of central autophagy proteins BAG3 and p62 in testicular cancer

  2. Bis expression was higher in squamous cell carcinoma than in adenocarcinoma in Lung Cancer.

  3. Data show although no any significant differences between patient groups and lean subjects of proteins SYT4 (show SYT4 Proteins), BAG3, APOA1 (show APOA1 Proteins), and VAV3 (show VAV3 Proteins), except for VGF (show VGF Proteins) protein, there was a trend between the expression of these four genes and their protein levels.

  4. our findings suggest the existence of a so-far unrecognized quality control mechanism involving BAG3, HSPB8 (show HSPB8 Proteins) and p62/SQSTM1 (show SQSTM1 Proteins) for accurate remodelling of actin-based mitotic structures that guide spindle orientation.

  5. BAG3 promotes pancreatic ductal adenocarcinoma growth by activating stromal macrophages.

  6. BAG3-mediated miRNA let-7g and let-7i inhibit proliferation and enhance apoptosis of human esophageal carcinoma cells by targeting the drug transporter ABCC10 (show ABCC10 Proteins) and modulates cisplatin resistance.

  7. This newly described ERa-mediated and estrogen response element (ERE)-independent non-canonical autophagy pathway, which involves the function of BAG3 and provides stress resistance in our model systems.

  8. BAG3 protein loci is involved in the pathophysiology of systolic heart failure.

  9. MiR (show MLXIP Proteins)-143 enhanced the tumor suppressive effect of shikonin partly through the regulation of BAG3 in glioblastoma stem cells.

  10. The Hsp70 (show HSP70 Proteins)-Bag3 interaction may be a promising, new target for anticancer therapy.

Mouse (Murine) BCL2-Associated Athanogene 3 (BAG3) interaction partners

  1. molecular association of MyHC and BIS is necessary for MyHC stabilization in skeletal muscle.

  2. BAG3 promotes pancreatic ductal adenocarcinoma growth by activating stromal macrophages.

  3. Bis is upregulated in astrocytes after hypoxia-ischemia; hypoxia-ischemia induces progressive cell death in the hippocampi of bis-positive mice, while hippocampal neurons are less vulnerable to hypoxia-ischemia in mice that lack Bis.

  4. Deletion of the bis gene results in a marked increase in the production of corticosterone that is associated with thymic atrophy.

  5. BAG3 and Hsc70 (show HSPA8 Proteins) interact with actin capping protein (show TMOD4 Proteins) CapZ (show CAPZA1 Proteins) to maintain myofibrillar integrity under mechanical stress.

  6. Results indicate that Bis functions to mediate cellular regulation of the stem cell niche on the vascular compartment.

  7. BAG3 alters the interaction between HSP70 (show HSP70 Proteins) and IKKgamma (show IKBKG Proteins), increasing availability of IKKgamma (show IKBKG Proteins) and protecting it from proteasome-dependent degradation; this, in turn, results in increased NF-kappaB (show NFKB1 Proteins) activity and survival

  8. BAG3 is not required for muscle development, this co-chaperone appears to be critically important for maintenance of mature skeletal muscle.

  9. The absence of Bis has considerable influences on postnatal growth and survival, possibly due to a nutritional impairment.

BAG3 Protein Profile

Protein Summary

BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The protein encoded by this gene contains a WW domain in the N-terminal region and a BAG domain in the C-terminal region. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner.

Gene names and symbols associated with BAG3

  • BCL2-associated athanogene 3 (bag3-A)
  • BCL2-associated athanogene 3 (bag3)
  • BCL2-associated athanogene 3 (BAG3)
  • BCL2-associated athanogene 3 (LOC100228262)
  • BCL-2-associated athanogene 3 (BAG3)
  • BCL2-associated athanogene 3 (Bag3)
  • Bcl2-associated athanogene 3 (Bag3)
  • BCL2-associated athanogene 3 (LOC100358030)
  • AA407278 protein
  • ATBAG3 protein
  • BAG-3 protein
  • BAG3 protein
  • bag3-A protein
  • BCL-2-associated athanogene 3 protein
  • Bis protein
  • CAIR-1 protein
  • MFM6 protein
  • mg638 protein
  • MGC53113 protein
  • T28J14.160 protein
  • T28J14_160 protein
  • zgc:100859 protein

Protein level used designations for BAG3

BCL2-associated athanogene 3 , BAG family molecular chaperone regulator 3 , BAG family molecular chaperone regulator 3-like , BCL2-binding athanogene 3 , bcl-2-binding protein Bis , docking protein CAIR-1 , BAG-3 , Bcl-2-binding protein Bis , Bcl-2-interacting death suppressor , bcl-2-associated athanogene 3

GENE ID SPECIES
379174 Xenopus laevis
445139 Danio rerio
450778 Pan troglodytes
714420 Macaca mulatta
100145358 Xenopus (Silurana) tropicalis
100228262 Taeniopygia guttata
100481230 Ailuropoda melanoleuca
830613 Arabidopsis thaliana
9531 Homo sapiens
29810 Mus musculus
293524 Rattus norvegicus
486916 Canis lupus familiaris
782633 Bos taurus
423931 Gallus gallus
100156989 Sus scrofa
100358030 Oryctolagus cuniculus
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