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BCLAF1 encodes a transcriptional repressor that interacts with several members of the BCL2 family of proteins. Additionally we are shipping BCLAF1 Antibodies (90) and and many more products for this protein.
The Bclaf1 can interact with the leucine zipper region of C/EBPbeta (show CEBPB ELISA Kits) and cooperate with C/EBPbeta (show CEBPB ELISA Kits) to upregulate IL-8 (show IL8 ELISA Kits).
both cytoplasmic BCLAF1 expression and nuclear BCLAF1 expression are increased in post-neoadjuvant therapy rectal cancer, and that negative and weak nuclear BCLAF1 expression are independently associated with a poor prognosis
SRSF10 is a key regulator of BCLAF1 pre-mRNA splicing and the maintenance of oncogenic features in human colon cancer cells
findings showed that FXR1P (show FXR1 ELISA Kits) interacts with BTF in vivo and proved that FXR1P (show FXR1 ELISA Kits) and BTF can co-localize mainly in the cytoplasm around the nucleus
BTF has functions distinct from TRAP150 (show THRAP3 ELISA Kits) in regulating the subcellular distribution of mRNAs in human cells.
BCLAF1 co-localized with gammaH2AX (show H2AFX ELISA Kits) foci in nuclei and stabilized the Ku70 (show XRCC6 ELISA Kits)/DNA-PKcs (show PRKDC ELISA Kits) complex therein, facilitating non-homologous end joining (NHEJ)-based DSB repair in surviving cells.
In the absence of BclAF1 neutralization, viral gene expression and replication are inhibited. These data identify two temporally and mechanistically distinct functions used by human cytomegalovirus to down-regulate a cellular antiviral protein
Sirt1 (show SIRT1 ELISA Kits) negatively regulates T cell activation via H3K56 deacetylation at the promoter region to inhibit transcription of Bclaf1
We replicated the association of BCL2L11 (show BCL2L11 ELISA Kits) and CASP9 (show CASP9 ELISA Kits) with non-Hodgkin's lymphoma risk at the gene and SNP level, and identified novel associations with BCLAF1 and BAG5 (show BAG5 ELISA Kits).
Findings indicate a role for BCLAF1 in post-transcriptional processes that impact mRNA metabolism.
Bclaf1 facilitates the differentiation of early retinal precursors into retinal ganglion cells, amacrine cells, and horizontal cells rather than into cone photoreceptors.
Bclaf1 expression was found to be strongly upregulated during the saccular stage of murine embryonic lung development and was dispensable for thymocyte development.
This gene encodes a transcriptional repressor that interacts with several members of the BCL2 family of proteins. Overexpression of this protein induces apoptosis, which can be suppressed by co-expression of BCL2 proteins. The protein localizes to dot-like structures throughout the nucleus, and redistributes to a zone near the nuclear envelope in cells undergoing apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene.
BCL2-associated transcription factor 1
, bcl-2-associated transcription factor 1
, mitochondrial fission regulator 2
, protein FAM54A