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anti-BCL2-Interacting Killer (Apoptosis-Inducing) (BIK) Antibodies

The protein encoded by BIK shares a critical BH3 domain with other death-promoting proteins, such as BID, BAK, BAD and BAX, that is required for its pro-apoptotic activity, and for interaction with anti-apoptotic members of the BCL2 family, and vira. Additionally we are shipping BCL2-Interacting Killer (Apoptosis-Inducing) Kits (5) and BCL2-Interacting Killer (Apoptosis-Inducing) Proteins (5) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
BIK 12124  
BIK 638 Q13323
BIK 114496  
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Top anti-BCL2-Interacting Killer (Apoptosis-Inducing) Antibodies at antibodies-online.com

Showing 10 out of 125 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated EIA, IHC (p), WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated WB Western blot analysis of BIK expression in Jurkat (Lane 1) mouse intes... 100 μg Log in to see 2 to 3 Days
$283.50
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated IHC (p), WB Western blot analysis of anti-Bik Pab (ABIN389524) in mouse liver tiss... Formalin-fixed and paraffin-embedded human cancer tissue reacted with ... 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated IHC (p), WB The anti-Bik BH3 domain Pab (ABIN388114) is used in Western blot to de... Formalin-fixed and paraffin-embedded human cancer tissue reacted with ... 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated IF, WB 0.1 mg Log in to see 6 to 8 Days
$423.50
Details
Human Mouse Un-conjugated IP, WB Western blot analysis of Bik in HEK-293 cells. Lane 1, 1 µg/mL of the ... 0.1 mg Log in to see 5 to 6 Days
$275.23
Details
Human Rabbit Un-conjugated EIA, IF, WB Immunocytochemistry of BIK in Jurkat cells with AP30150PU-N BIK antibo... Western blot analysis of BIK in Jurkat cell lysate with AP30150PU-N BI... 0.1 mg Log in to see 6 to 8 Days
$401.50
Details
Human Rabbit Un-conjugated EIA, IF, IHC (p), WB 0.1 mg Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated IHC, ELISA, WB Western blot analysis of extracts from K562 cells, using BIK (Phospho-... Immunohistochemistry analysis of paraffin-embedded human lung carcinom... 100 μg Log in to see 2 to 3 Days
$275.00
Details

BIK Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality
Mouse (Murine) , , , ,

Human , , , ,
,
Rat (Rattus) , ,

Top referenced anti-BCL2-Interacting Killer (Apoptosis-Inducing) Antibodies

  1. Human Monoclonal BIK Primary Antibody for IP, WB - ABIN967566 : Boyd, Gallo, Elangovan, Houghton, Malstrom, Avery, Ebb, Subramanian, Chittenden, Lutz: Bik, a novel death-inducing protein shares a distinct sequence motif with Bcl-2 family proteins and interacts with viral and cellular survival-promoting proteins. in Oncogene 1995 (PubMed)
    Show all 5 references for ABIN967566

  2. Human Polyclonal BIK Primary Antibody for EIA, IHC (p) - ABIN358090 : Nikrad, Johnson, Puthalalath, Coultas, Adams, Kraft: The proteasome inhibitor bortezomib sensitizes cells to killing by death receptor ligand TRAIL via BH3-only proteins Bik and Bim. in Molecular cancer therapeutics 2005 (PubMed)
    Show all 5 references for ABIN358090

  3. Human Polyclonal BIK Primary Antibody for IHC (p), WB - ABIN388114 : Gillissen, Essmann, Graupner, Stärck, Radetzki, Dörken, Schulze-Osthoff, Daniel: Induction of cell death by the BH3-only Bcl-2 homolog Nbk/Bik is mediated by an entirely Bax-dependent mitochondrial pathway. in The EMBO journal 2003 (PubMed)
    Show all 3 references for ABIN388114

  4. Human Polyclonal BIK Primary Antibody for EIA, IF - ABIN499467 : Germain, Mathai, McBride, Shore: Endoplasmic reticulum BIK initiates DRP1-regulated remodelling of mitochondrial cristae during apoptosis. in The EMBO journal 2005 (PubMed)
    Show all 3 references for ABIN499467

  5. Human Polyclonal BIK Primary Antibody for IHC (p), WB - ABIN389524 : Arena, Martini, Luongo, Capelli, Larocca: Mutations of the BIK gene in human peripheral B-cell lymphomas. in Genes, chromosomes & cancer 2003 (PubMed)
    Show all 2 references for ABIN389524

  6. Human Polyclonal BIK Primary Antibody for IF, WB - ABIN318742 : Mathai, Germain, Shore: BH3-only BIK regulates BAX,BAK-dependent release of Ca2+ from endoplasmic reticulum stores and mitochondrial apoptosis during stress-induced cell death. in The Journal of biological chemistry 2005 (PubMed)

  7. Human Polyclonal BIK Primary Antibody for WB - ABIN223382 : Chen, Huang, Wang: Deficiency of Bim in dendritic cells contributes to overactivation of lymphocytes and autoimmunity. in Blood 2007 (PubMed)

  8. Human Polyclonal BIK Primary Antibody for EIA, IHC (p) - ABIN356832 : Sass, Shembade, Haimerl, Lamoureux, Hashemolhosseini, Tannapfel, Tiegs: TNF pretreatment interferes with mitochondrial apoptosis in the mouse liver by A20-mediated down-regulation of Bax. in Journal of immunology (Baltimore, Md. : 1950) 2007 (PubMed)

More Antibodies against BCL2-Interacting Killer (Apoptosis-Inducing) Interaction Partners

Mouse (Murine) BCL2-Interacting Killer (Apoptosis-Inducing) (BIK) interaction partners

  1. Findings identify novel cross talk between autophagy and apoptosis, wherein targeting SQSTM1/p62 (show SQSTM1 Antibodies) converts cytoprotective autophagy to an inefficient form due to cargo loading failure, leading to NBK/Bik accumulation, which triggers apoptosis.

  2. Src (show SRC Antibodies) tyrosine kinase (show TYRO3 Antibodies) inhibits apoptosis through the Erk1/2 (show MAPK1/3 Antibodies)- dependent degradation of the death accelerator Bik.

  3. The Bik protein, even in combination with Noxa (show PMAIP1 Antibodies), is not a potent suppressor of c-Myc (show MYC Antibodies)-driven tumourigenesis or critical for chemotherapeutic drug-induced killing of Myc (show MYC Antibodies)-driven tumours.

  4. BIKDD, a constitutively active mutant form of proapoptotic gene, BIK, effectively induces apoptosis of breast cancer cells and synergizes with lapatinib.

  5. Blk has been mapped to chromosome 15 and overexpressed in transitional B cells of A/WySnJ mice, which demonstrate a cell-autonomous defect leading to excessive apoptosis.

  6. any function of Bik in programmed cell death and stress-induced apoptosis must overlap that of other BH3-only (show BBC3 Antibodies) proteins

  7. Data show that Bik and Bim (show BCL2L11 Antibodies) share the role of eliminating supernumerary germ cells during the first wave of spermatogenesis, a process vital for normal testicular development.

  8. Targeted expression of BikDD, a potent proapoptotic gene driven by CCKAR (show CCKAR Antibodies)-VISA (show MAVS Antibodies), exhibited antitumor effects on pancreatic cancer and prolonged survival in multiple xenograft and syngeneic mouse models of pancreatic tumors with virtually no toxicity

  9. evaluated the inhibitory effect of BikDD on the growth kinetics of intraperitoneally inoculated CT-26 (show DDX53 Antibodies)-Luc

  10. Enhanced expression in Bcl-2 (show BCL2 Antibodies) deficient cells leads to cell death with autophagic features.

Human BCL2-Interacting Killer (Apoptosis-Inducing) (BIK) interaction partners

  1. our data demonstrated that suppression of BIK in ER-positive MCF-7 cells prevents the cytotoxic effect of TAM (show CCNA1 Antibodies) and favors a more aggressive phenotype, due to the molecular change of different pathways

  2. HCV RNA replication and release were significantly suppressed in BIK-depleted cells and over-expression of the RNA-dependent RNA polymerase, NS5B, was able to induce BIK expression

  3. BikDDA, a novel mutant of Bik, showed a prolonged half-life and enhanced pro-apoptotic ability in triple-negative breast cancer cells compared with BikDD.

  4. Findings identify novel cross talk between autophagy and apoptosis, wherein targeting SQSTM1/p62 (show SQSTM1 Antibodies) converts cytoprotective autophagy to an inefficient form due to cargo loading failure, leading to NBK/Bik accumulation, which triggers apoptosis.

  5. Authors show that human herpesvirus 4 EBNA2 represses BIK in B-cell lymphoma-derived cell lines and that this host-virus interaction can inhibit the proapoptotic effect of transforming growth factor beta1.

  6. Data suggest BIK expression in tumor cells is not subject to direct regulation by MAP kinase (show MAPK1 Antibodies) signaling; BIK expression appears to be cell-cycle-dependent and increases in G1 cell-cycle arrest which results from inhibition of MAP kinase (show MAPK1 Antibodies) signaling.

  7. BIK/NBK gene expression may have important clinical implications and provide predictive, prognostic or therapeutic marker in breast cancer patients

  8. Src (show SRC Antibodies) tyrosine kinase (show TXK Antibodies) inhibits apoptosis through the Erk1/2 (show MAPK1/3 Antibodies)- dependent degradation of the death accelerator Bik.

  9. A previously undescribed indirect epigenetic regulation of BIK in FA-C lymphoblasts is mediated by DeltaNp73, an isoform of p73 (show TP73 Antibodies) lacking its transactivation domain that activates BIK through a proximal element in its promoter.

  10. Data indicate that methylation-induced transcriptional silencing of the BIK (bcl2-interacting killer) pro-apoptotic gene may occur in multiple myeloma (MM), which might serve as a predictor of the development of relapsed/refractory MM.

BCL2-Interacting Killer (Apoptosis-Inducing) (BIK) Antigen Profile

Protein Summary

The protein encoded by this gene shares a critical BH3 domain with other death-promoting proteins, such as BID, BAK, BAD and BAX, that is required for its pro-apoptotic activity, and for interaction with anti-apoptotic members of the BCL2 family, and viral survival-promoting proteins. Since the activity of this protein is suppressed in the presence of survival-promoting proteins, it is suggested as a likely target for anti-apoptotic proteins.

Gene names and symbols associated with BIK

  • BCL2-interacting killer (apoptosis-inducing) (BIK) antibody
  • BCL2-interacting killer (BIK) antibody
  • BCL2-interacting killer (Bik) antibody
  • BCL2-interacting killer (apoptosis-inducing) (Bik) antibody
  • BCL2-interacting killer (apoptosis-inducing) (bik) antibody
  • BIK antibody
  • Biklk antibody
  • BIP1 antibody
  • Blk antibody
  • BP4 antibody
  • NBK antibody
  • si:dkey-31f5.6 antibody

Protein level used designations for BIK

BCL2-interacting killer (apoptosis-inducing) , BCL2-interacting killer , apoptosis inducer NBK , bcl-2-interacting killer , bik-like killer protein , apoptosis-inducing NBK

GENE ID SPECIES
470232 Pan troglodytes
711479 Macaca mulatta
790946 Felis catus
12124 Mus musculus
638 Homo sapiens
114496 Rattus norvegicus
564030 Danio rerio
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