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The protein encoded by BIK shares a critical BH3 domain with other death-promoting proteins, such as BID, BAK, BAD and BAX, that is required for its pro-apoptotic activity, and for interaction with anti-apoptotic members of the BCL2 family, and viral survival-promoting proteins. Additionally we are shipping BIK Kits (5) and BIK Proteins (5) and many more products for this protein.
Showing 10 out of 127 products:
Human Monoclonal BIK Primary Antibody for IP, WB - ABIN967566
Boyd, Gallo, Elangovan, Houghton, Malstrom, Avery, Ebb, Subramanian, Chittenden, Lutz: Bik, a novel death-inducing protein shares a distinct sequence motif with Bcl-2 family proteins and interacts with viral and cellular survival-promoting proteins. in Oncogene 1995
Show all 5 references for ABIN967566
Human Polyclonal BIK Primary Antibody for EIA, IHC (p) - ABIN358090
Nikrad, Johnson, Puthalalath, Coultas, Adams, Kraft: The proteasome inhibitor bortezomib sensitizes cells to killing by death receptor ligand TRAIL via BH3-only proteins Bik and Bim. in Molecular cancer therapeutics 2005
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Human Polyclonal BIK Primary Antibody for IHC (p), WB - ABIN388114
Gillissen, Essmann, Graupner, Stärck, Radetzki, Dörken, Schulze-Osthoff, Daniel: Induction of cell death by the BH3-only Bcl-2 homolog Nbk/Bik is mediated by an entirely Bax-dependent mitochondrial pathway. in The EMBO journal 2003
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Human Polyclonal BIK Primary Antibody for EIA, IF - ABIN499467
Germain, Mathai, McBride, Shore: Endoplasmic reticulum BIK initiates DRP1-regulated remodelling of mitochondrial cristae during apoptosis. in The EMBO journal 2005
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Human Polyclonal BIK Primary Antibody for IHC (p), WB - ABIN389524
Arena, Martini, Luongo, Capelli, Larocca: Mutations of the BIK gene in human peripheral B-cell lymphomas. in Genes, chromosomes & cancer 2003
Show all 2 references for ABIN389524
Human Polyclonal BIK Primary Antibody for IF, WB - ABIN318742
Mathai, Germain, Shore: BH3-only BIK regulates BAX,BAK-dependent release of Ca2+ from endoplasmic reticulum stores and mitochondrial apoptosis during stress-induced cell death. in The Journal of biological chemistry 2005
Human Polyclonal BIK Primary Antibody for WB - ABIN223382
Chen, Huang, Wang: Deficiency of Bim in dendritic cells contributes to overactivation of lymphocytes and autoimmunity. in Blood 2007
Human Polyclonal BIK Primary Antibody for EIA, IHC (p) - ABIN356832
Sass, Shembade, Haimerl, Lamoureux, Hashemolhosseini, Tannapfel, Tiegs: TNF pretreatment interferes with mitochondrial apoptosis in the mouse liver by A20-mediated down-regulation of Bax. in Journal of immunology (Baltimore, Md. : 1950) 2007
OPN (show SPP1 Antibodies) induces oxidative stress via the involvement of mitochondria and NOX-4 (show NOX4 Antibodies). It may affect mitochondrial morphology and integrity, at least in part, via the involvement of BIK.
Findings identify novel cross talk between autophagy and apoptosis, wherein targeting SQSTM1/p62 (show SQSTM1 Antibodies) converts cytoprotective autophagy to an inefficient form due to cargo loading failure, leading to NBK/Bik accumulation, which triggers apoptosis.
Src (show SRC Antibodies) tyrosine kinase (show TYRO3 Antibodies) inhibits apoptosis through the Erk1/2 (show MAPK1/3 Antibodies)- dependent degradation of the death accelerator Bik.
The Bik protein, even in combination with Noxa (show PMAIP1 Antibodies), is not a potent suppressor of c-Myc (show MYC Antibodies)-driven tumourigenesis or critical for chemotherapeutic drug-induced killing of Myc (show MYC Antibodies)-driven tumours.
BIKDD, a constitutively active mutant form of proapoptotic gene, BIK, effectively induces apoptosis of breast cancer cells and synergizes with lapatinib.
Blk has been mapped to chromosome 15 and overexpressed in transitional B cells of A/WySnJ mice, which demonstrate a cell-autonomous defect leading to excessive apoptosis.
any function of Bik in programmed cell death and stress-induced apoptosis must overlap that of other BH3-only (show BBC3 Antibodies) proteins
Data show that Bik and Bim (show BCL2L11 Antibodies) share the role of eliminating supernumerary germ cells during the first wave of spermatogenesis, a process vital for normal testicular development.
Targeted expression of BikDD, a potent proapoptotic gene driven by CCKAR (show CCKAR Antibodies)-VISA (show MAVS Antibodies), exhibited antitumor effects on pancreatic cancer and prolonged survival in multiple xenograft and syngeneic mouse models of pancreatic tumors with virtually no toxicity
evaluated the inhibitory effect of BikDD on the growth kinetics of intraperitoneally inoculated CT-26 (show DDX53 Antibodies)-Luc
our data demonstrated that suppression of BIK in ER-positive MCF-7 cells prevents the cytotoxic effect of TAM (show CCNA1 Antibodies) and favors a more aggressive phenotype, due to the molecular change of different pathways
HCV RNA replication and release were significantly suppressed in BIK-depleted cells and over-expression of the RNA-dependent RNA polymerase, NS5B, was able to induce BIK expression
BikDDA, a novel mutant of Bik, showed a prolonged half-life and enhanced pro-apoptotic ability in triple-negative breast cancer cells compared with BikDD.
Authors show that human herpesvirus 4 EBNA2 represses BIK in B-cell lymphoma-derived cell lines and that this host-virus interaction can inhibit the proapoptotic effect of transforming growth factor beta1.
Data suggest BIK expression in tumor cells is not subject to direct regulation by MAP kinase (show MAPK1 Antibodies) signaling; BIK expression appears to be cell-cycle-dependent and increases in G1 cell-cycle arrest which results from inhibition of MAP kinase (show MAPK1 Antibodies) signaling.
BIK/NBK gene expression may have important clinical implications and provide predictive, prognostic or therapeutic marker in breast cancer patients
Src (show SRC Antibodies) tyrosine kinase (show TXK Antibodies) inhibits apoptosis through the Erk1/2 (show MAPK1/3 Antibodies)- dependent degradation of the death accelerator Bik.
A previously undescribed indirect epigenetic regulation of BIK in FA-C lymphoblasts is mediated by DeltaNp73, an isoform of p73 (show TP73 Antibodies) lacking its transactivation domain that activates BIK through a proximal element in its promoter.
Data indicate that methylation-induced transcriptional silencing of the BIK (bcl2-interacting killer) pro-apoptotic gene may occur in multiple myeloma (MM), which might serve as a predictor of the development of relapsed/refractory MM.
The protein encoded by this gene shares a critical BH3 domain with other death-promoting proteins, such as BID, BAK, BAD and BAX, that is required for its pro-apoptotic activity, and for interaction with anti-apoptotic members of the BCL2 family, and viral survival-promoting proteins. Since the activity of this protein is suppressed in the presence of survival-promoting proteins, it is suggested as a likely target for anti-apoptotic proteins.
BCL2-interacting killer (apoptosis-inducing)
, BCL2-interacting killer
, apoptosis inducer NBK
, bcl-2-interacting killer
, bik-like killer protein
, apoptosis-inducing NBK