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BCL2-Like 12 (Proline Rich) Proteins (BCL2L12)

The protein encoded by BCL2L12 belongs to the BCL-2 protein family. Additionally we are shipping BCL2L12 Antibodies (56) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
BCL2L12 83596 Q9HB09
Mouse BCL2L12 BCL2L12 75736  
Rat BCL2L12 BCL2L12 361567  
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Top BCL2L12 Proteins at

Showing 3 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human GST tag 100 μg Log in to see 16 Days
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 1 mg Log in to see 29 to 34 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days

BCL2L12 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,

Top referenced BCL2L12 Proteins

  1. Human BCL2L12 Protein expressed in Escherichia coli (E. coli) - ABIN2006230 : Hammond, Alpin, Rise, Wright, Kreider: In vitro selection and characterization of Bcl-X(L)-binding proteins from a mix of tissue-specific mRNA display libraries. in The Journal of biological chemistry 2001 (PubMed)

More Proteins for BCL2-Like 12 (Proline Rich) (BCL2L12) Interaction Partners

Human BCL2-Like 12 (Proline Rich) (BCL2L12) interaction partners

  1. Identify 50 novel BCL2L12 splice variants in human tumor cell lines.

  2. Results show that high Bcl2L12 mRNA expression was associated with the high-grade breast cancer and triple-negative (TNBC) subtype. Also, the interplay between Bcl2L12 and its variant may be associated with high lymph node metastasis in non-TNBC tumors.

  3. CD82 (show CD82 Proteins) regulated BCL2L12 expression via STAT5A (show STAT5A Proteins) and AKT (show AKT1 Proteins) signaling and stimulated proliferation and engrafting of leukemia cells.

  4. Bcl2L12 retains a BH3-like domain, which is important for its anti-apoptotic property.

  5. Data indicate that BCL2-like 12 (proline rich) protein (show C4BPA Proteins) BCL2L12 mRNA levels can distinguish women with breast cancer from healthy controls.

  6. Data indicate that BCL2L12 expression levels were associated with poor disease-free survival of the high-grade TaT1 bladder cancer patients.

  7. Bcl2L12 was previously shown to inhibit apoptosis through binding to caspase 7 (show CASP7 Proteins).

  8. cisplatin treatment induced a time-dependent apoptosis in glioblastoma cells, at least partially via downregulation of BCL2L12 gene expression.

  9. Acute myeloid leukemia (show BCL11A Proteins) patients have a lower level of BCL2L12 gene expression.

  10. Protein made from F17F mutant BCL2L12 transcript bound p53 (show TP53 Proteins), inhibited UV-induced apoptosis more efficiently than WT BCL2L12, and reduced endogenous p53 (show TP53 Proteins) target gene transcription.

Mouse (Murine) BCL2-Like 12 (Proline Rich) (BCL2L12) interaction partners

  1. nuclear Bcl2L12 physically and functionally interacts with the p53 tumor suppressor (show TP53 Proteins)

  2. Data show that apoptotic defect in Irf3 (show IRF3 Proteins)(-/-)Bcl2l12(-/-) MEFs was rescued by the ectopic expression of Bcl2L12, but not IRF3 (show IRF3 Proteins).

BCL2L12 Protein Profile

Protein Summary

The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein contains a Bcl-2 homology domain 2 (BH2). The function of this gene has not yet been determined. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

Gene names and symbols associated with BCL2L12

  • BCL2-like 12 (proline rich) (BCL2L12)
  • BCL2-like 12 (proline rich) (Bcl2l12)
  • 2810475P17Rik protein
  • 5430429M05Rik protein
  • Bcl-L12 protein
  • Bcl2-L12 protein

Protein level used designations for BCL2L12

Bcl-2 related proline-rich protein , bcl-2-like protein 12 , bcl-2-related proline-rich protein , bcl2-L-12

83596 Homo sapiens
100688537 Canis lupus familiaris
533338 Bos taurus
75736 Mus musculus
361567 Rattus norvegicus
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