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The protein encoded by BCL2L12 belongs to the BCL-2 protein family. Additionally we are shipping BCL2L12 Antibodies (56) and many more products for this protein.
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Human BCL2L12 Protein expressed in Escherichia coli (E. coli) - ABIN2006230
Hammond, Alpin, Rise, Wright, Kreider: In vitro selection and characterization of Bcl-X(L)-binding proteins from a mix of tissue-specific mRNA display libraries. in The Journal of biological chemistry 2001
Identify 50 novel BCL2L12 splice variants in human tumor cell lines.
Results show that high Bcl2L12 mRNA expression was associated with the high-grade breast cancer and triple-negative (TNBC) subtype. Also, the interplay between Bcl2L12 and its variant may be associated with high lymph node metastasis in non-TNBC tumors.
CD82 (show CD82 Proteins) regulated BCL2L12 expression via STAT5A (show STAT5A Proteins) and AKT (show AKT1 Proteins) signaling and stimulated proliferation and engrafting of leukemia cells.
Bcl2L12 retains a BH3-like domain, which is important for its anti-apoptotic property.
Data indicate that BCL2-like 12 (proline rich) protein (show C4BPA Proteins) BCL2L12 mRNA levels can distinguish women with breast cancer from healthy controls.
Data indicate that BCL2L12 expression levels were associated with poor disease-free survival of the high-grade TaT1 bladder cancer patients.
Bcl2L12 was previously shown to inhibit apoptosis through binding to caspase 7 (show CASP7 Proteins).
cisplatin treatment induced a time-dependent apoptosis in glioblastoma cells, at least partially via downregulation of BCL2L12 gene expression.
Acute myeloid leukemia (show BCL11A Proteins) patients have a lower level of BCL2L12 gene expression.
Protein made from F17F mutant BCL2L12 transcript bound p53 (show TP53 Proteins), inhibited UV-induced apoptosis more efficiently than WT BCL2L12, and reduced endogenous p53 (show TP53 Proteins) target gene transcription.
nuclear Bcl2L12 physically and functionally interacts with the p53 tumor suppressor (show TP53 Proteins)
Data show that apoptotic defect in Irf3 (show IRF3 Proteins)(-/-)Bcl2l12(-/-) MEFs was rescued by the ectopic expression of Bcl2L12, but not IRF3 (show IRF3 Proteins).
The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein contains a Bcl-2 homology domain 2 (BH2). The function of this gene has not yet been determined. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
Bcl-2 related proline-rich protein
, bcl-2-like protein 12
, bcl-2-related proline-rich protein