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BCL2/adenovirus E1B 19kDa Interacting Protein 3 Proteins (BNIP3)

BNIP3 is a member of the BCL2/adenovirus E1B 19 kd-interacting protein (BNIP) family. Additionally we are shipping BNIP3 Antibodies (117) and BNIP3 Kits (6) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
BNIP3 664 Q12983
BNIP3 12176 O55003
Rat BNIP3 BNIP3 84480  
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Top BNIP3 Proteins at antibodies-online.com

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Escherichia coli (E. coli) Human His tag   50 μg Log in to see 5 Days
$522.50
Details

BNIP3 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

More Proteins for BCL2/adenovirus E1B 19kDa Interacting Protein 3 (BNIP3) Interaction Partners

Human BCL2/adenovirus E1B 19kDa Interacting Protein 3 (BNIP3) interaction partners

  1. Results suggest that changes in mitochondrial morphology and transmembrane potential, induced by mutant htt (show HTT Proteins) protein, are dependent and linked to BNip3 and not to Bax (show BAX Proteins)/Bak (show BAK1 Proteins) activation.

  2. Hypoxia-induced autophagy contributes to the invasion of salivary adenoid cystic carcinoma through the HIF-1alpha (show HIF1A Proteins)/BNIP3 signaling pathway.

  3. The data indicated that BNIP3 plays a vital role in the tumorigenesis of adenoid cystic carcinoma and could be a new target for gene therapy of adenoid cystic carcinoma.

  4. BNIP3 deletion can be used as a prognostic (show HIF1A Proteins)marker of tumor progression to metastasis in human triple-negative breast cancer

  5. BNIP3 expression was found to be regulated by Sp3 in prostate cancer.

  6. phosphorylation of these C-terminal BNIP3 residues blocks cell death without preventing autophagy, providing evidence that the two functional roles of BNIP3 can be regulated independently

  7. Bnip3 dual-functionality and crosstalk between mitophagy and apoptosis pathways is presented here.

  8. these findings revealed that silibinin induced autophagic cell death through ROS (show ROS1 Proteins)-dependent mitochondrial dysfunction and ATP depletion involving BNIP3 in MCF7 cells.

  9. The findings of the present study reveal a novel survival pathway that functionally couples the unique glycolytic phenotype in cancer cells to hypoxia resistance via a PDK2 (show PDK2 Proteins)-dependent mechanism that switches Bnip3 from cell death to survival.

  10. Mevalonate depletion through HMG-CoA reductase (show HMGCR Proteins) inhibition impairs the viability of primary human mesenchymal stells via NF-kappaB (show NFKB1 Proteins)/Bnip3 signaling.

Mouse (Murine) BCL2/adenovirus E1B 19kDa Interacting Protein 3 (BNIP3) interaction partners

  1. Data show that TGFbeta (show TGFB1 Proteins)-activated kinase-1 (TAK1 (show NR2C2 Proteins)) activated nuclear factor of activated T-cells (NFAT (show NFATC1 Proteins))/NF-kappa B (NFkappaB (show NFKB1 Proteins)), downregulated BCL2-adenovirus E1B interacting protein 3 (Bnip3), and inhibited cardiac cell death.

  2. propose that BNIP3 acts as a brake on HIF-1 (show HIF1A Proteins) activity serving to increase rates of mitophagy in response to hypoxia and to limit production of damaging ROS (show ROS1 Proteins) that would further amplify HIF-1 (show HIF1A Proteins) expression and promote tumor progression to metastasis

  3. Results suggest that Bnip3 regulates cardiac gene expression and perhaps myocyte morphology by activating nuclear p300 acetyltransferase and hyperacetylating histones and its selective transcription factors.

  4. Bnip3 dual-functionality and crosstalk between mitophagy and apoptosis pathways is presented here.

  5. regulates mitophagy during hypoxia, whereas NIX (show BNIP3L Proteins) is required for mitophagy during development of the erythroid lineage.

  6. BNIP3 primarily regulates basal level of mitophagy in physiological conditions, whereas BNIP3 exclusively activates excessive mitophagy leading to cell death.

  7. Bnip3 generation, mediated by PARP1 (show PARP1 Proteins), causes mitochondrial damage and neuron death.

  8. Suggest pro-tumorigenic role of BNIP3 driving melanoma cell's aggressive features, like migration and vasculogenic mimicry.

  9. BNIP3 has a protective effect against UVB-induced apoptosis in keratinocytes

  10. The BNIP3 cell death pathway may be a new target for protecting oligodendrocytes from death after stroke

BNIP3 Protein Profile

Protein Summary

This gene is a member of the BCL2/adenovirus E1B 19 kd-interacting protein (BNIP) family. It interacts with the E1B 19 kDa protein, which protects cells from virally-induced cell death. The encoded protein also interacts with E1B 19 kDa-like sequences of BCL2, another apoptotic protector. This protein contains a BH3 domain and a transmembrane domain, which have been associated with pro-apoptotic function. The dimeric mitochondrial protein encoded by this gene is known to induce apoptosis, even in the presence of BCL2.

Gene names and symbols associated with BNIP3

  • BCL2/adenovirus E1B 19kDa interacting protein 3 (BNIP3)
  • BCL2/adenovirus E1B interacting protein 3 (Bnip3)
  • Nip3 protein

Protein level used designations for BNIP3

BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 , BCL2/adenovirus E1B 19kD-interacting protein 3 , BCL2/adenovirus E1B 19 kDa-interacting protein 1, NIP3 , BCL2/adenovirus E1B 19kDa-interacting protein 1, NIP3 , BCL2/adenovirus E1B interacting protein 1, NIP3 , BCL2/adenovirus E1B 19 kDa-interacting protein 3

GENE ID SPECIES
664 Homo sapiens
423971 Gallus gallus
607408 Canis lupus familiaris
615342 Bos taurus
12176 Mus musculus
84480 Rattus norvegicus
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