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Induces apoptosis. Additionally we are shipping and many more products for this protein.
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Bnip3L and caspase-12 (show CASP12 ELISA Kits) identified by the PCR arrays at both catagen stages were additionally localized using immunofluorescence and were reported in physiological hair development for the first time.
our study demonstrates that BNIP3L, as a substrate of PARK2 (show PARK2 ELISA Kits), promotes mitophagy in the PINK1/PARK2 (show PARK2 ELISA Kits) pathway associated with PD pathogenesis.
Suggest Nix is a novel mediator of norepinephrine-induced fibrosis.
MicroRNA-137 has a role in inhibiting mitophagy via regulation of two mitophagy receptors FUNDC1 (show FUNDC1 ELISA Kits) and NIX
-stimulated cytoplasmic-nuclear shuttling of the alternately spliced non-mitochondrial Nix isoform and uncover a role for sNix as a modulator of TNFalpha/NFkappaB-stimulated cardiac gene expression
BNIP3L activity localizes to a small region in its cytoplasmic domain, the minimal essential region (MER (show ERH ELISA Kits)).
These results establish Nix as a critical mediator of beta cell apoptosis and programmed necrosis in Pdx1 (show PDX1 ELISA Kits)-deficient diabetes.
molecular events responsible for the different phases of mitophagy and placed Nix upstream of the events
Mitochondrial Nix activates Bax (show BAX ELISA Kits)/Bak (show BAK1 ELISA Kits)- and caspase (show CASP3 ELISA Kits)-dependent apoptosis, whereas ER-Nix activates Bax (show BAX ELISA Kits)/Bak (show BAK1 ELISA Kits)-independent, MPTP (show PTPN2 ELISA Kits)-dependent necrosis.
Nix functions as an autophagy receptor, which mediates mitochondrial clearance after mitochondrial damage and during erythrocyte differentiation
Induces apoptosis. Interacts with viral and cellular anti-apoptosis proteins. Can overcome the suppressors BCL-2 and BCL-XL, although high levels of BCL-XL expression will inhibit apoptosis. Inhibits apoptosis induced by BNIP3. Involved in mitochondrial quality control via its interaction with to mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. May function as a tumor suppressor (By similarity).
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like
, BCL2/adenovirus E1B 19 kDa-interacting protein 3-like
, BCL2/adenovirus E1B 19kDa-interacting protein 3-like
, NIP3-like protein X