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The oncogene BCL2 is a membrane protein that blocks a step in a pathway leading to apoptosis or programmed cell death. Additionally we are shipping BAG1 Antibodies (126) and BAG1 Proteins (16) and many more products for this protein.
Increased BAG-1 by PD-L1 (show CD274 ELISA Kits) confers resistance to tyrosine kinase (show TXK ELISA Kits) inhibitor in non-small cell lung cancer via persistent activation of ERK (show EPHB2 ELISA Kits) signaling.
BAG-4/SODD (show BAG4 ELISA Kits), HSP70 (show HSP70 ELISA Kits), and HSP90 (show HSP90 ELISA Kits) are potential prognostic markers in node-negative breast carcinoma that merit further research.
interaction with Bag1 then shifts hERG (show KCNH2 ELISA Kits) degradation to the membrane-anchored E3 ligase TRC8 (show RNF139 ELISA Kits) and its E2-conjugating enzyme Ube2g2 (show UBE2G2 ELISA Kits), as determined by siRNA screening
These results suggest that Bag1 and Bag3 (show BAG3 ELISA Kits) control the stability of the Hsc70 (show HSPA8 ELISA Kits)-client complex using at least two distinct protein-protein contacts, providing a previously under-appreciated layer of molecular regulation in the human Hsc70 (show HSPA8 ELISA Kits) system.
Taken together, these data indicate that Bag-1 up-regulation is required to maintain apoptosis resistance in human cytomegalovirus-infected cells.
the combined effects of BAG-1 and XPD (show ERCC2 ELISA Kits) polymorphisms on chemotherapy sensitivity and survival in patients with advanced non-small-cell lung cancer, which might be the important predictive markers for platinum-based chemotherapy efficacy.
Bag-1 indirectly affects cell survival through c-Myc (show MYC ELISA Kits) activated signalling that causes elevation of ornithine decarboxylase (show ODC1 ELISA Kits) levels, leading to an increase of the polyamine content.
Overexpression of miR (show MLXIP ELISA Kits)-138 inhibited cell proliferation by directly suppressing the expression of Bag-1.
The expression of BAG-1 was upregulated in chronic non-eosinophilic rhinosinusitis.
BAG-1 expression was high in esophageal carcinoma tissues compared to normal esophagus. After Eca109 cells were transfected with BAG-1-siRNA, the proliferation and invasive capabilities of the cells were decreased while the apoptosis rate was enhanced.
The BAG-1 stabilizes F508del-CFTR by direct binding, probably competing out ubiquitin to partially avoid its proteasomal degradation.
The membrane form of heparin binding EGF-like growth factor (show HBEGF ELISA Kits) (ProHB-EGF (show EGF ELISA Kits)) is most likely able to trigger the nuclear translocation of BAG-1 in keeping its level high.
Hemoxygenase (show HMOX1 ELISA Kits) 1 deficiency provoked diminished Bag-1 level upon LPS (show TLR4 ELISA Kits) treatment
this study first reported the solution structure of mBAG-1 (show LRRC4 ELISA Kits)-UBH and the growth factor precursor-interacting motif on the protein.
Bag-1 proteins function as regulators of the action of selective transcription factors.
during development of mouse autopods, BAG-1 expression is downregulated upon the initiation of interdigital apoptosis (BAG-1)
Bag1 is a regulator and marker of neuronal differentiation
BAG1 displays potent neuroprotective activity in vivo against stroke.
Since, BAG-1 is essential for cell survival, its association with tNhtt aggregates might disrupt its normal function and thereby promote polyglutamine-expanded tNhtt-induced cell death.
Bag1 is essential for differentiation and survival of hematopoietic and neuronal cells.
The oncogene BCL2 is a membrane protein that blocks a step in a pathway leading to apoptosis or programmed cell death. The protein encoded by this gene binds to BCL2 and is referred to as BCL2-associated athanogene. It enhances the anti-apoptotic effects of BCL2 and represents a link between growth factor receptors and anti-apoptotic mechanisms. Multiple protein isoforms are encoded by this mRNA through the use of a non-AUG (CUG) initiation codon, and three alternative downstream AUG initiation codons. A related pseudogene has been defined on chromosome X.
, BCL2-associated athanogene
, BAG family molecular chaperone regulator 1
, Bcl-2 associating athanogene-1 protein
, Bcl-2-binding protein
, glucocortoid receptor-associated protein RAP46
, receptor-associated protein, 46-KD
, bcl-2-associated athanogene 1