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The oncogene BCL2 is a membrane protein that blocks a step in a pathway leading to apoptosis or programmed cell death. Additionally we are shipping BAG1 Antibodies (129) and many more products for this protein.
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Increased BAG-1 by PD-L1 (show CD274 Proteins) confers resistance to tyrosine kinase (show TXK Proteins) inhibitor in non-small cell lung cancer via persistent activation of ERK (show EPHB2 Proteins) signaling.
BAG-4/SODD (show BAG4 Proteins), HSP70 (show HSP70 Proteins), and HSP90 (show HSP90 Proteins) are potential prognostic markers in node-negative breast carcinoma that merit further research.
interaction with Bag1 then shifts hERG (show KCNH2 Proteins) degradation to the membrane-anchored E3 ligase TRC8 (show RNF139 Proteins) and its E2-conjugating enzyme Ube2g2 (show UBE2G2 Proteins), as determined by siRNA screening
These results suggest that Bag1 and Bag3 (show BAG3 Proteins) control the stability of the Hsc70 (show HSPA8 Proteins)-client complex using at least two distinct protein-protein contacts, providing a previously under-appreciated layer of molecular regulation in the human Hsc70 (show HSPA8 Proteins) system.
Taken together, these data indicate that Bag-1 up-regulation is required to maintain apoptosis resistance in human cytomegalovirus-infected cells.
the combined effects of BAG-1 and XPD (show ERCC2 Proteins) polymorphisms on chemotherapy sensitivity and survival in patients with advanced non-small-cell lung cancer, which might be the important predictive markers for platinum-based chemotherapy efficacy.
Bag-1 indirectly affects cell survival through c-Myc (show MYC Proteins) activated signalling that causes elevation of ornithine decarboxylase (show ODC1 Proteins) levels, leading to an increase of the polyamine content.
Overexpression of miR (show MLXIP Proteins)-138 inhibited cell proliferation by directly suppressing the expression of Bag-1.
The expression of BAG-1 was upregulated in chronic non-eosinophilic rhinosinusitis.
BAG-1 expression was high in esophageal carcinoma tissues compared to normal esophagus. After Eca109 cells were transfected with BAG-1-siRNA, the proliferation and invasive capabilities of the cells were decreased while the apoptosis rate was enhanced.
The BAG-1 stabilizes F508del-CFTR by direct binding, probably competing out ubiquitin to partially avoid its proteasomal degradation.
The membrane form of heparin binding EGF-like growth factor (show HBEGF Proteins) (ProHB-EGF (show EGF Proteins)) is most likely able to trigger the nuclear translocation of BAG-1 in keeping its level high.
Hemoxygenase (show HMOX1 Proteins) 1 deficiency provoked diminished Bag-1 level upon LPS (show TLR4 Proteins) treatment
this study first reported the solution structure of mBAG-1 (show LRRC4 Proteins)-UBH and the growth factor precursor-interacting motif on the protein.
Bag-1 proteins function as regulators of the action of selective transcription factors.
during development of mouse autopods, BAG-1 expression is downregulated upon the initiation of interdigital apoptosis (BAG-1)
Bag1 is a regulator and marker of neuronal differentiation
BAG1 displays potent neuroprotective activity in vivo against stroke.
Since, BAG-1 is essential for cell survival, its association with tNhtt aggregates might disrupt its normal function and thereby promote polyglutamine-expanded tNhtt-induced cell death.
Bag1 is essential for differentiation and survival of hematopoietic and neuronal cells.
The oncogene BCL2 is a membrane protein that blocks a step in a pathway leading to apoptosis or programmed cell death. The protein encoded by this gene binds to BCL2 and is referred to as BCL2-associated athanogene. It enhances the anti-apoptotic effects of BCL2 and represents a link between growth factor receptors and anti-apoptotic mechanisms. Multiple protein isoforms are encoded by this mRNA through the use of a non-AUG (CUG) initiation codon, and three alternative downstream AUG initiation codons. A related pseudogene has been defined on chromosome X.
, BCL2-associated athanogene
, BAG family molecular chaperone regulator 1
, Bcl-2 associating athanogene-1 protein
, Bcl-2-binding protein
, glucocortoid receptor-associated protein RAP46
, receptor-associated protein, 46-KD
, bcl-2-associated athanogene 1