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BPI Fold Containing Family A, Member 1 Proteins (BPIFA1)

BPIFA1 is the human homolog of murine plunc, and like the mouse gene, is specifically expressed in the upper airways and nasopharyngeal regions. Additionally we are shipping BPIFA1 Antibodies (41) and BPIFA1 Kits (27) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
BPIFA1 51297 Q9NP55
BPIFA1 18843 P97361
BPIFA1 246238 Q8K4I4
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Top BPIFA1 Proteins at antibodies-online.com

Showing 7 out of 9 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 7 to 8 Days
$319.00
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$2,597.83
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$2,643.67
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

BPIFA1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

Rat (Rattus)

Top referenced BPIFA1 Proteins

  1. Human BPIFA1 Protein expressed in Escherichia coli (E. coli) - ABIN1098511 : Bingle, Craven: PLUNC: a novel family of candidate host defence proteins expressed in the upper airways and nasopharynx. in Human molecular genetics 2002 (PubMed)
    Show all 2 references for ABIN1098511

  2. Human BPIFA1 Protein expressed in Wheat germ - ABIN1315483 : Nicholas, Skipp, Barton, Singh, Bagmane, Mould, Angco, Ward, Guha-Niyogi, Wilson, Howarth, Davies, Rennard, OConnor, Djukanovic: Identification of lipocalin and apolipoprotein A1 as biomarkers of chronic obstructive pulmonary disease. in American journal of respiratory and critical care medicine 2010 (PubMed)

More Proteins for BPI Fold Containing Family A, Member 1 (BPIFA1) Interaction Partners

Human BPI Fold Containing Family A, Member 1 (BPIFA1) interaction partners

  1. These studies identify the role of SPLUNC1 in sinonasal innate immunity and the pathogenesis of CRS (show CARS Proteins). Defective expression of SPLUNC1 in CRSwNP patients may lead to insufficient maintenance of the epithelial barrier function

  2. High serum SPLUNC1 levels are associated with Pleural Effusion from Lung Cancer Compared to Tuberculosis.

  3. PLUNC is a protein of the tear film and suggest that it plays a role in fluid balance and surface tension regulation at the ocular surface.

  4. SPLUNC1 can weaken the inflammatory response induced by EBV infection in NPC (show NPC1 Proteins) cells through the regulation of the TLR9 (show TLR9 Proteins)/NF-kappaB (show NFKB1 Proteins) signaling pathway and control of the tumor inflammatory microenvironment

  5. The G allele of rs1078761 may be detrimental to lung function in cystic fibrosis (show S100A8 Proteins) owing to decreased levels of BPIFA1 and BPIFB1 (show BPIFB1 Proteins).

  6. LUNX silencing disrupted primary tumor growth, local invasion, and metastatic colonization

  7. pleural fluid LUNX mRNA provided a valuable adjunct in distinguishing malignant pleural effusion caused by lung cancer from benign pleural effusion

  8. The observations suggest that, in response to agents or chemical factors, nasal mucosal epithelium will react and produce PLUNC proteins

  9. discoveries provide insight into the specific determinants governing the interaction between SPLUNC1 and lipids and also shed light on novel functions that SPLUNC1 and other PLUNC family members perform in host defense

  10. 12 retinoid X receptors heterodimer binding sites exist in the SPLUNC1 promoter region, which is up-regulated by all-trans-retinoic acid. SPLUNC1 plays a role in ATRA-induced growth inhibition and differentiation in nasopharyngeal carcinoma cells.

Pig (Porcine) BPI Fold Containing Family A, Member 1 (BPIFA1) interaction partners

Mouse (Murine) BPI Fold Containing Family A, Member 1 (BPIFA1) interaction partners

  1. Loss of Splunc1 predisposes mice to the development of otitis media.

  2. SPLUNC1 is a crucial component of mucosal innate immune defense against pulmonary infection.

  3. SPLUNC1 is present at high concentrations in murine airways under basal conditions, whereas it is suppressed by low-level environmental pathogen-associated molecular patterns and inflammatory signals.

  4. SPLUNC1 KO mice demonstrated significantly higher numbers of eosinophils in the lung after OVA challenges than did wild-type mice.

  5. Our findings demonstrate a critical in vivo role of SPLUNC1 in host defense against bacterial infection

  6. Our data for the first time suggest that airway epithelial TLR2 signaling is pivotal in mycoplasma-induced SPLUNC1 production.

  7. splunc5, splunc1, and lplunc1 (show BPIFB1 Proteins) are expressed in unique domains along a continuous corridor of oral, lingual, pharyngeal, and respiratory epithelia

  8. SPLUNC1 protein decreases Mycoplasma pneumoniae (Mp) levels and inhibits epithelial IL-8 (show IL8 Proteins) production induced by Mp-derived lipoproteins.

BPIFA1 Protein Profile

Protein Summary

This gene is the human homolog of murine plunc, and like the mouse gene, is specifically expressed in the upper airways and nasopharyngeal regions. The exact biological function of this gene is not known, however, it has been suggested to be involved in inflammatory responses to irritants in the upper airways. It may also serve as a potential molecular marker for detection of micrometastasis in non-small-cell lung cancer. Multiple transcript variants resulting from alternative splicing in the 3' UTR have been detected, but the full-length nature of only three are known.

Gene names and symbols associated with BPIFA1

  • BPI fold containing family A, member 1 (BPIFA1)
  • BPI fold containing family A, member 1 (Bpifa1)
  • bA49G10.5 protein
  • LUNX protein
  • NASG protein
  • Plunc protein
  • SPLUNC1 protein
  • SPURT protein

Protein level used designations for BPIFA1

BPI fold-containing family A member 1 , ligand-binding protein RYA3 , lung-specific protein X , nasopharyngeal carcinoma-related protein , palate lung and nasal epithelium clone protein , palate, lung and nasal epithelium associated , protein Plunc , secretory protein in upper respiratory tracts , tracheal epithelium enriched protein , tracheal epithelium-enriched protein , von Ebner protein Hl , palate, lung and nasal epithelium carcinoma associated , lung and nasal epithelium carcinoma-associated protein , palate, lung and nasal epithelium carcinoma associated protein , palate, lung, and nasal epithelium associated , palate, lung, and nasal epithelium clone , palate, lung, and nasal epithelium expressed transcript , ES cell-related protein , palate, lung, and nasal epithelium carcinoma associated protein

GENE ID SPECIES
51297 Homo sapiens
609982 Canis lupus familiaris
449524 Sus scrofa
281989 Bos taurus
18843 Mus musculus
246238 Rattus norvegicus
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