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Serine/threonine-protein kinase that plays a key role in polarization of neurons and centrosome duplication. Additionally we are shipping BRSK1 Proteins (5) and BRSK1 Kits (4) and many more products for this protein.
Showing 10 out of 121 products:
Mouse (Murine) Polyclonal BRSK1 Primary Antibody for WB - ABIN1881121
Alvarado-Kristensson, Rodríguez, Silió, Valpuesta, Carrera: SADB phosphorylation of gamma-tubulin regulates centrosome duplication. in Nature cell biology 2009
Show all 3 references for ABIN1881121
Human Polyclonal BRSK1 Primary Antibody for EIA, WB - ABIN360694
Lu, Niida, Nakanishi: Human SAD1 kinase is involved in UV-induced DNA damage checkpoint function. in The Journal of biological chemistry 2004
Show all 2 references for ABIN360694
Human Polyclonal BRSK1 Primary Antibody for EIA, IHC (p) - ABIN499501
Kishi, Pan, Crump, Sanes: Mammalian SAD kinases are required for neuronal polarization. in Science (New York, N.Y.) 2005
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Human Polyclonal BRSK1 Primary Antibody for IHC (p), WB - ABIN652432
Lizcano, Göransson, Toth, Deak, Morrice, Boudeau, Hawley, Udd, Mäkelä, Hardie, Alessi: LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1. in The EMBO journal 2004
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Human Polyclonal BRSK1 Primary Antibody for IHC (p), WB - ABIN303016
Zempel, Thies, Mandelkow, Mandelkow: Abeta oligomers cause localized Ca(2+) elevation, missorting of endogenous Tau into dendrites, Tau phosphorylation, and destruction of microtubules and spines. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2010
These results suggest that frameshift mutations of EGR1 (show EGR1 Antibodies) and BRSK1 might play a role in tumorigenesis through tumor suppressor gene inactivation in colorectal cancer and gastric cancer.
BRSK1 is a novel tumor suppressor in breast cancer which inversely correlated with Jab1 (show COPS5 Antibodies) expression.
Single nucleotide polymorphism in BRSK1 is associated with the length of reproductive lifespan.
acts as checkpoint kinase (show ATR Antibodies) upon DNA damage induced by UV
protein phosphatase 2C (show PDP Antibodies) is a likely candidate for catalyzing the dephosphorylation and inactivation of BRSK1/2.
STRADalpha.MO25alpha complexes containing LKB1 (show STK11 Antibodies) variants were equally effective at phosphorylating and activating AMPK (show PRKAA1 Antibodies), BRSK1, and BRSK2 (show BRSK2 Antibodies)
SADB kinase activity controls centrosome homeostasis by regulating phosphorylation of gamma-tubulin (show TUBG1 Antibodies).
Structure and inhibition analysis of the mouse SAD-B C-terminal fragment
At mature pre-synaptic terminals, SAD-B regulates vesicular release probability and synaptic plasticity.
SAD-A (show BRSK2 Antibodies) and SAD-B kinases have multiple, sequential roles in axonal differentiation
The regulation of Wee1 (show WEE1 Antibodies) by SadA (show BRSK2 Antibodies) and SadB kinases is essential for the differentiation of polarized neurons.
results show that SAD-A (show BRSK2 Antibodies) and SAD-B, mammalian orthologs of a kinase needed for presynaptic differentiation in Caenorhabditis elegans, are required for neuronal polarization.
Once activated, LKB1 (show STK11 Antibodies) phosphorylates and thereby activates SAD-A (show BRSK2 Antibodies) and SAD-B kinases, which are also required for neuronal polarization in the cerebral cortex.
Serine/threonine-protein kinase that plays a key role in polarization of neurons and centrosome duplication. Phosphorylates CDC25B, CDC25C, MAPT/TAU, RIMS1, TUBG1, TUBG2 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Ser-573'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in post-mitotic neurons, leading to down-regulate WEE1 activity in polarized neurons. Also acts as a positive regulator of centrosome duplication by mediating phosphorylation of gamma-tubulin (TUBG1 and TUBG2) at 'Ser-131', leading to translocation of gamma-tubulin and its associated proteins to the centrosome. Involved in the UV- induced DNA damage checkpoint response, probably by inhibiting CDK1 activity through phosphorylation and activation of WEE1, and inhibition of CDC25B and CDC25C (By similarity). In neurons, localizes to synaptic vesicles and plays a role in neurotransmitter release, possibly by phosphorylating RIMS1.
BR serine/threonine kinase 1
, BR serine/threonine-protein kinase 1-like
, BR serine/threonine-protein kinase 1
, SAD1 homolog
, SAD1 kinase
, SadB kinase short isoform
, brain-selective kinase 1
, brain-specific serine/threonine-protein kinase 1
, protein kinase SAD1A
, serine/threonine-protein kinase BRSK1
, serine/threonine-protein kinase SAD-B
, synapses of Amphids Defective homolog 1
, serine/threonine kinase SAD-B
, serine/threonine kinase SADB