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anti-BR Serine/threonine Kinase 1 (BRSK1) Antibodies

Serine/threonine-protein kinase that plays a key role in polarization of neurons and centrosome duplication. Additionally we are shipping BRSK1 Kits (8) and BRSK1 Proteins (5) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
BRSK1 84446 Q8TDC3
BRSK1 381979 Q5RJI5
BRSK1 499073 B2DD29
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Top anti-BRSK1 Antibodies at antibodies-online.com

Showing 10 out of 116 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated EIA, WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated IHC (p), WB KIAA1811 Antibody (S685) (ABIN652432) western blot analysis in mouse liver tissue lysates (35 µg/lane).This demonstrates the KIAA1811 antibody detected the KIAA1811 protein (arrow). BRSK1 Antibody (C-term) (ABIN652432)immunohistochemistry analysis in formalin fixed and paraffin embedded human testis tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated IHC (p), WB 50 μg Log in to see 6 to 8 Days
$500.50
Details
Mouse Rabbit Un-conjugated WB BRSK1 Antibody (Center) (ABIN1881121) western blot analysis in mouse brain tissue lysates (35 µg/lane). This demonstrates the BRSK1 antibody detected the BRSK1 protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB Immunohistochemistry of BRSK1 in human brain tissue with BRSK1 antibody at 2.5 μg/ml. Western blot analysis of BRSK1 in human brain tissue lysate with AP30166PU-N BRSK1 antibody at (A) 0.5 and (B) 1 μg/ml. 0.1 mg Log in to see 6 to 8 Days
$401.50
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB Immunohistochemistry of BRSK1 in human brain tissue with BRSK1 antibody at 5 μg/ml. Western blot analysis of BRSK1 in human brain tissue lysate with AP30167PU-N BRSK1 antibody at (A) 0.5, (B) 1 and (C) 2 μg/ml. 0.1 mg Log in to see 6 to 8 Days
$401.50
Details
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of extracts from 293 cells, using BRSK1 Antibody. The lane on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated IHC (p), WB Brain, cortex 50 μg Log in to see 8 to 10 Days
$451.00
Details
Human Rabbit Un-conjugated IHC (p), WB Human Brain, Cortex (formalin-fixed, paraffin-embedded) stained with BRSK1 antibody ABIN214287 at 5 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody ABIN481713, alkaline phosphatase-streptavidin and chromogen. 50 μg Log in to see 8 to 10 Days
$451.00
Details

BRSK1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-BRSK1 Antibodies

  1. Mouse (Murine) Polyclonal BRSK1 Primary Antibody for WB - ABIN1881121 : Alvarado-Kristensson, Rodríguez, Silió, Valpuesta, Carrera: SADB phosphorylation of gamma-tubulin regulates centrosome duplication. in Nature cell biology 2009 (PubMed)
    Show all 3 references for ABIN1881121

  2. Human Polyclonal BRSK1 Primary Antibody for EIA, WB - ABIN360694 : Lu, Niida, Nakanishi: Human SAD1 kinase is involved in UV-induced DNA damage checkpoint function. in The Journal of biological chemistry 2004 (PubMed)
    Show all 2 references for ABIN360694

  3. Human Polyclonal BRSK1 Primary Antibody for EIA, IHC (p) - ABIN499501 : Kishi, Pan, Crump, Sanes: Mammalian SAD kinases are required for neuronal polarization. in Science (New York, N.Y.) 2005 (PubMed)
    Show all 2 references for ABIN499501

  4. Human Polyclonal BRSK1 Primary Antibody for IHC (p), WB - ABIN652432 : Lizcano, Göransson, Toth, Deak, Morrice, Boudeau, Hawley, Udd, Mäkelä, Hardie, Alessi: LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1. in The EMBO journal 2004 (PubMed)
    Show all 2 references for ABIN652432

  5. Human Polyclonal BRSK1 Primary Antibody for IHC (p), WB - ABIN303016 : Zempel, Thies, Mandelkow, Mandelkow: Abeta oligomers cause localized Ca(2+) elevation, missorting of endogenous Tau into dendrites, Tau phosphorylation, and destruction of microtubules and spines. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2010 (PubMed)

More Antibodies against BRSK1 Interaction Partners

Human BR Serine/threonine Kinase 1 (BRSK1) interaction partners

  1. BRSK1 is a novel tumor suppressor in breast cancer which inversely correlated with Jab1 (show COPS5 Antibodies) expression.

  2. Single nucleotide polymorphism in BRSK1 is associated with the length of reproductive lifespan.

  3. acts as checkpoint kinase (show ATR Antibodies) upon DNA damage induced by UV

  4. protein phosphatase 2C (show PDP Antibodies) is a likely candidate for catalyzing the dephosphorylation and inactivation of BRSK1/2.

  5. STRADalpha.MO25alpha complexes containing LKB1 (show STK11 Antibodies) variants were equally effective at phosphorylating and activating AMPK (show PRKAA1 Antibodies), BRSK1, and BRSK2 (show BRSK2 Antibodies)

  6. SADB kinase activity controls centrosome homeostasis by regulating phosphorylation of gamma-tubulin (show TUBG1 Antibodies).

Mouse (Murine) BR Serine/threonine Kinase 1 (BRSK1) interaction partners

  1. At mature pre-synaptic terminals, SAD-B regulates vesicular release probability and synaptic plasticity.

  2. SAD-A (show BRSK2 Antibodies) and SAD-B kinases have multiple, sequential roles in axonal differentiation

  3. The regulation of Wee1 (show WEE1 Antibodies) by SadA (show BRSK2 Antibodies) and SadB kinases is essential for the differentiation of polarized neurons.

  4. results show that SAD-A (show BRSK2 Antibodies) and SAD-B, mammalian orthologs of a kinase needed for presynaptic differentiation in Caenorhabditis elegans, are required for neuronal polarization.

  5. Once activated, LKB1 (show STK11 Antibodies) phosphorylates and thereby activates SAD-A (show BRSK2 Antibodies) and SAD-B kinases, which are also required for neuronal polarization in the cerebral cortex.

  6. SADB kinase activity controls centrosome homeostasis by regulating phosphorylation of gamma-tubulin (show TUBG1 Antibodies).

BRSK1 Antigen Profile

Protein Summary

Serine/threonine-protein kinase that plays a key role in polarization of neurons and centrosome duplication. Phosphorylates CDC25B, CDC25C, MAPT/TAU, RIMS1, TUBG1, TUBG2 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Ser-573'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in post-mitotic neurons, leading to down-regulate WEE1 activity in polarized neurons. Also acts as a positive regulator of centrosome duplication by mediating phosphorylation of gamma-tubulin (TUBG1 and TUBG2) at 'Ser-131', leading to translocation of gamma-tubulin and its associated proteins to the centrosome. Involved in the UV- induced DNA damage checkpoint response, probably by inhibiting CDK1 activity through phosphorylation and activation of WEE1, and inhibition of CDC25B and CDC25C (By similarity). In neurons, localizes to synaptic vesicles and plays a role in neurotransmitter release, possibly by phosphorylating RIMS1.

Gene names and symbols associated with BRSK1

  • BR serine/threonine kinase 1 (BRSK1) antibody
  • BR serine/threonine kinase 1 (LOC100352646) antibody
  • BR serine/threonine kinase 1 (Brsk1) antibody
  • BRSK1 antibody
  • Gm1100 antibody
  • hSAD1 antibody
  • RGD1563268 antibody
  • Sad-b antibody
  • SADB antibody

Protein level used designations for BRSK1

BR serine/threonine kinase 1 , BR serine/threonine-protein kinase 1-like , BR serine/threonine-protein kinase 1 , SAD1 homolog , SAD1 kinase , SadB kinase short isoform , brain-selective kinase 1 , brain-specific serine/threonine-protein kinase 1 , protein kinase SAD1A , serine/threonine-protein kinase BRSK1 , serine/threonine-protein kinase SAD-B , synapses of Amphids Defective homolog 1 , serine/threonine kinase SAD-B , serine/threonine kinase SADB

GENE ID SPECIES
100055612 Equus caballus
484297 Canis lupus familiaris
700287 Macaca mulatta
100352646 Oryctolagus cuniculus
100450205 Pongo abelii
100477927 Ailuropoda melanoleuca
100610477 Pan troglodytes
84446 Homo sapiens
381979 Mus musculus
499073 Rattus norvegicus
100512610 Sus scrofa
538009 Bos taurus
Selected quality suppliers for anti-BRSK1 (BRSK1) Antibodies
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