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BR Serine/threonine Kinase 1 Proteins (BRSK1)

Serine/threonine-protein kinase that plays a key role in polarization of neurons and centrosome duplication. Additionally we are shipping BRSK1 Antibodies (116) and BRSK1 Kits (8) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
BRSK1 84446 Q8TDC3
BRSK1 381979 Q5RJI5
BRSK1 499073 B2DD29
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Top BRSK1 Proteins at antibodies-online.com

Showing 5 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$4,282.67
Details
HOST_Baculovirus infected Insect Cells Mouse GST tag   5 μg Log in to see 10 to 12 Days
$322.08
Details

BRSK1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine) ,
,
Rat (Rattus)

More Proteins for BR Serine/threonine Kinase 1 (BRSK1) Interaction Partners

Human BR Serine/threonine Kinase 1 (BRSK1) interaction partners

  1. BRSK1 is a novel tumor suppressor in breast cancer which inversely correlated with Jab1 (show COPS5 Proteins) expression.

  2. Single nucleotide polymorphism in BRSK1 is associated with the length of reproductive lifespan.

  3. acts as checkpoint kinase upon DNA damage induced by UV

  4. protein phosphatase 2C (show PDP Proteins) is a likely candidate for catalyzing the dephosphorylation and inactivation of BRSK1/2.

  5. STRADalpha.MO25alpha complexes containing LKB1 (show STK11 Proteins) variants were equally effective at phosphorylating and activating AMPK (show PRKAA1 Proteins), BRSK1, and BRSK2 (show BRSK2 Proteins)

  6. SADB kinase activity controls centrosome homeostasis by regulating phosphorylation of gamma-tubulin (show TUBG1 Proteins).

Mouse (Murine) BR Serine/threonine Kinase 1 (BRSK1) interaction partners

  1. At mature pre-synaptic terminals, SAD-B regulates vesicular release probability and synaptic plasticity.

  2. SAD-A (show BRSK2 Proteins) and SAD-B kinases have multiple, sequential roles in axonal differentiation

  3. The regulation of Wee1 (show WEE1 Proteins) by SadA (show BRSK2 Proteins) and SadB kinases is essential for the differentiation of polarized neurons.

  4. results show that SAD-A (show BRSK2 Proteins) and SAD-B, mammalian orthologs of a kinase needed for presynaptic differentiation in Caenorhabditis elegans, are required for neuronal polarization.

  5. Once activated, LKB1 (show STK11 Proteins) phosphorylates and thereby activates SAD-A (show BRSK2 Proteins) and SAD-B kinases, which are also required for neuronal polarization in the cerebral cortex.

  6. SADB kinase activity controls centrosome homeostasis by regulating phosphorylation of gamma-tubulin (show TUBG1 Proteins).

BRSK1 Protein Profile

Protein Summary

Serine/threonine-protein kinase that plays a key role in polarization of neurons and centrosome duplication. Phosphorylates CDC25B, CDC25C, MAPT/TAU, RIMS1, TUBG1, TUBG2 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Ser-573'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in post-mitotic neurons, leading to down-regulate WEE1 activity in polarized neurons. Also acts as a positive regulator of centrosome duplication by mediating phosphorylation of gamma-tubulin (TUBG1 and TUBG2) at 'Ser-131', leading to translocation of gamma-tubulin and its associated proteins to the centrosome. Involved in the UV- induced DNA damage checkpoint response, probably by inhibiting CDK1 activity through phosphorylation and activation of WEE1, and inhibition of CDC25B and CDC25C (By similarity). In neurons, localizes to synaptic vesicles and plays a role in neurotransmitter release, possibly by phosphorylating RIMS1.

Gene names and symbols associated with BRSK1

  • BR serine/threonine kinase 1 (BRSK1)
  • BR serine/threonine kinase 1 (LOC100352646)
  • BR serine/threonine kinase 1 (Brsk1)
  • BRSK1 protein
  • Gm1100 protein
  • hSAD1 protein
  • RGD1563268 protein
  • Sad-b protein
  • SADB protein

Protein level used designations for BRSK1

BR serine/threonine kinase 1 , BR serine/threonine-protein kinase 1-like , BR serine/threonine-protein kinase 1 , SAD1 homolog , SAD1 kinase , SadB kinase short isoform , brain-selective kinase 1 , brain-specific serine/threonine-protein kinase 1 , protein kinase SAD1A , serine/threonine-protein kinase BRSK1 , serine/threonine-protein kinase SAD-B , synapses of Amphids Defective homolog 1 , serine/threonine kinase SAD-B , serine/threonine kinase SADB

GENE ID SPECIES
100055612 Equus caballus
484297 Canis lupus familiaris
700287 Macaca mulatta
100352646 Oryctolagus cuniculus
100450205 Pongo abelii
100477927 Ailuropoda melanoleuca
100610477 Pan troglodytes
84446 Homo sapiens
381979 Mus musculus
499073 Rattus norvegicus
100512610 Sus scrofa
538009 Bos taurus
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