You are viewing an incomplete version of our website. Please click to reload the website as full version.

BR serine/threonine Kinase 2 Proteins (BRSK2)

Serine/threonine-protein kinase that plays a key role in polarization of neurons. Additionally we are shipping BR serine/threonine Kinase 2 Antibodies (72) and BR serine/threonine Kinase 2 Kits (7) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
BRSK2 9024 Q8IWQ3
BRSK2 75770 Q69Z98
BRSK2 293631  
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online
  • orders@antibodies-online.com

Top BR serine/threonine Kinase 2 Proteins at antibodies-online.com

Showing 6 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$4,148.83
Details
HOST_Baculovirus infected Insect Cells Human GST tag   5 μg Log in to see 10 to 12 Days
$322.08
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 19 Days
$785.40
Details

BRSK2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
,
Mouse (Murine)

Rat (Rattus)

More Proteins for BR serine/threonine Kinase 2 (BRSK2) Interaction Partners

Human BR serine/threonine Kinase 2 (BRSK2) interaction partners

  1. SAD-A and AMPK (show PRKAA1 Proteins) kinases are regulators of mTORC1 signaling in the pancreatic beta-cells.

  2. BRSK2 interacted with VCP/p97 (show vcp Proteins) via three of the four functional domains of VCP/p97 (show vcp Proteins). Immunofluorescence demonstrated that BRSK2 and VCP/p97 (show vcp Proteins) were co-localized and also that knockdown of endogenous BRSK2 induced increased levels of CD3delta (show CD3D Proteins).

  3. Anaphase-promoting complex/cyclosome-Cdh1 (show CDH1 Proteins), rather than Cdc20 (show CDC20 Proteins), promotes the degradation of BRSK2 in vivo.

  4. a novel function of BRSK2 in the regulation of GSIS in beta-cells via a PCTAIRE1 (show CDK16 Proteins)-dependent mechanism and suggest that BRSK2 is an attractive target for developing novel diabetic drugs.

  5. these findings demonstrate ER stress may reduce BRSK2 protein and change BRSK2 subcellular localization, which in turn alleviate ER stress-induced apoptosis.

  6. these findings provide a novel regulatory mechanism of BRSK2 through direct interaction with Jab1 (show COPS5 Proteins).

  7. BRSK2 is up-regulated in pancreatic ductal adenocarcinoma.

  8. BRSK2 may be an autoantigen involved in the pathogenesis of small-cell lung cancer-associated limbic encephalitis.

  9. we identified cAMP-dependent protein kinase A (PKA) as another upstream kinase of BRSK2, which can phosphorylate BRSK2 at Thr260. Kinase activity of BRSK2 can be increased through phosphorylation by PKA.

  10. protein phosphatase 2C (show PDP Proteins) is a likely candidate for catalyzing the dephosphorylation and inactivation of BRSK1 (show BRSK1 Proteins)/2.

Mouse (Murine) BR serine/threonine Kinase 2 (BRSK2) interaction partners

  1. SAD-A and AMPK (show PRKAA1 Proteins) kinases are regulators of mTORC1 signaling in the pancreatic beta-cells.

  2. SAD-A and SAD-B (show BRSK1 Proteins) kinases have multiple, sequential roles in axonal differentiation

  3. SAD-A kinase controls islet beta-cell size and function as a mediator of mTORC1 signaling.

  4. SAD-A kinase is a pancreas-specific mediator of incretin response in islet beta cells.

  5. a novel function of BRSK2 in the regulation of GSIS in beta-cells via a PCTAIRE1 (show CDK16 Proteins)-dependent mechanism and suggest that BRSK2 is an attractive target for developing novel diabetic drugs.

  6. a critical role of SAD-A in the activation of PAK1 (show PAK1 Proteins) during the onset of insulin (show INS Proteins) exocytosis.

  7. The regulation of Wee1 (show WEE1 Proteins) by SadA and SadB (show BRSK1 Proteins) kinases is essential for the differentiation of polarized neurons.

  8. results show that SAD-A and SAD-B (show BRSK1 Proteins), mammalian orthologs of a kinase needed for presynaptic differentiation in Caenorhabditis elegans, are required for neuronal polarization.

  9. Once activated, LKB1 (show STK11 Proteins) phosphorylates and thereby activates SAD-A and SAD-B (show BRSK1 Proteins) kinases, which are also required for neuronal polarization in the cerebral cortex.

BR serine/threonine Kinase 2 (BRSK2) Protein Profile

Protein Summary

Serine/threonine-protein kinase that plays a key role in polarization of neurons. Phosphorylates MAPT/TAU and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Ser-554'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in post-mitotic neurons, leading to down-regulate WEE1 activity in polarized neurons.

Gene names and symbols associated with BRSK2

  • BR serine/threonine kinase 2 (BRSK2)
  • BR serine/threonine kinase 2 (Brsk2)
  • 4833424K13Rik protein
  • BRSK2 protein
  • C11orf7 protein
  • PEN11B protein
  • SAD-A protein
  • SAD1 protein
  • SADA protein
  • STK29 protein

Protein level used designations for BRSK2

BR serine/threonine-protein kinase 2 , BR serine/threonine kinase 2 , BR serine/threonine-protein kinase 2-like , brain-selective kinase 2 , brain-specific serine/threonine-protein kinase 2 , protein kinase SAD1B , serine/threonine-protein kinase 29 , serine/threonine-protein kinase BRSK2 , serine/threonine-protein kinase SAD-A , brain serine/threonine kinase 2

GENE ID SPECIES
423098 Gallus gallus
535868 Bos taurus
744454 Pan troglodytes
746226 Pan troglodytes
100395256 Callithrix jacchus
100429659 Macaca mulatta
100443903 Pongo abelii
9024 Homo sapiens
75770 Mus musculus
483658 Canis lupus familiaris
293631 Rattus norvegicus
Selected quality suppliers for BR serine/threonine Kinase 2 Proteins (BRSK2)
Did you look for something else?