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Serine/threonine-protein kinase that plays a key role in polarization of neurons. Additionally we are shipping BR serine/threonine Kinase 2 Antibodies (70) and BR serine/threonine Kinase 2 Kits (3) and many more products for this protein.
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SAD-A and AMPK (show PRKAA1 Proteins) kinases are regulators of mTORC1 signaling in the pancreatic beta-cells.
BRSK2 interacted with VCP/p97 (show vcp Proteins) via three of the four functional domains of VCP/p97 (show vcp Proteins). Immunofluorescence demonstrated that BRSK2 and VCP/p97 (show vcp Proteins) were co-localized and also that knockdown of endogenous BRSK2 induced increased levels of CD3delta (show CD3D Proteins).
Anaphase-promoting complex/cyclosome-Cdh1 (show CDH1 Proteins), rather than Cdc20 (show CDC20 Proteins), promotes the degradation of BRSK2 in vivo.
a novel function of BRSK2 in the regulation of GSIS in beta-cells via a PCTAIRE1 (show CDK16 Proteins)-dependent mechanism and suggest that BRSK2 is an attractive target for developing novel diabetic drugs.
these findings demonstrate ER stress may reduce BRSK2 protein and change BRSK2 subcellular localization, which in turn alleviate ER stress-induced apoptosis.
these findings provide a novel regulatory mechanism of BRSK2 through direct interaction with Jab1 (show COPS5 Proteins).
BRSK2 is up-regulated in pancreatic ductal adenocarcinoma.
BRSK2 may be an autoantigen involved in the pathogenesis of small-cell lung cancer-associated limbic encephalitis.
we identified cAMP-dependent protein kinase A (PKA) as another upstream kinase of BRSK2, which can phosphorylate BRSK2 at Thr260. Kinase activity of BRSK2 can be increased through phosphorylation by PKA.
protein phosphatase 2C (show PDP Proteins) is a likely candidate for catalyzing the dephosphorylation and inactivation of BRSK1 (show BRSK1 Proteins)/2.
SAD-A and SAD-B (show BRSK1 Proteins) kinases have multiple, sequential roles in axonal differentiation
SAD-A kinase controls islet beta-cell size and function as a mediator of mTORC1 signaling.
SAD-A kinase is a pancreas-specific mediator of incretin response in islet beta cells.
a critical role of SAD-A in the activation of PAK1 (show PAK1 Proteins) during the onset of insulin (show INS Proteins) exocytosis.
The regulation of Wee1 (show WEE1 Proteins) by SadA and SadB (show BRSK1 Proteins) kinases is essential for the differentiation of polarized neurons.
results show that SAD-A and SAD-B (show BRSK1 Proteins), mammalian orthologs of a kinase needed for presynaptic differentiation in Caenorhabditis elegans, are required for neuronal polarization.
Once activated, LKB1 (show STK11 Proteins) phosphorylates and thereby activates SAD-A and SAD-B (show BRSK1 Proteins) kinases, which are also required for neuronal polarization in the cerebral cortex.
Serine/threonine-protein kinase that plays a key role in polarization of neurons. Phosphorylates MAPT/TAU and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Ser-554'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in post-mitotic neurons, leading to down-regulate WEE1 activity in polarized neurons.
BR serine/threonine-protein kinase 2
, BR serine/threonine kinase 2
, BR serine/threonine-protein kinase 2-like
, brain-selective kinase 2
, brain-specific serine/threonine-protein kinase 2
, protein kinase SAD1B
, serine/threonine-protein kinase 29
, serine/threonine-protein kinase BRSK2
, serine/threonine-protein kinase SAD-A
, brain serine/threonine kinase 2