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The protein encoded by BAP1 localizes to the nucleus and it interacts with the RING finger domain of the breast cancer 1, early onset protein (BRCA1). Additionally we are shipping BAP1 Antibodies (127) and BAP1 Proteins (7) and many more products for this protein.
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Bap1 as a metabolic regulator in liver and pancreas.
the interaction between nephrin and MAGI-1 regulates Rap1 activation in podocytes to maintain long term slit diaphragm structure
BAP1(+/-) mice exposed to low-dose asbestos fibers showed an altered peritoneal inflammatory response and higher levels of pro-tumorigenic alternatively polarized M2 macrophages, and lower cytokine levels. They had a higher incidence of mesothelioma.
Bap1 loss led to a fully penetrant myeloproliferative disease with splenomegaly, leukocytosis, anemia and progenitor expansion via alterations in histone methylation and gene expression.
INO80 (show INO80 ELISA Kits) is stabilized and targeted to replication forks by BAP1 during normal DNA synthesis but downregulated in BAP1 defective cancer cells
Both Vhl (show VHL ELISA Kits) and Bap1 are required for kidney function. Inactivation of Bap1 in neprhon progenitor cells causes renal failure earlier than Vhl (show VHL ELISA Kits) inactivation. Bap1 is also a stronger tumor suppressor gene than Vhl (show VHL ELISA Kits) in the kidney.
Drawing parallels to human disease, these unbiased genetic findings indicate that BAP1 mutation carriers are predisposed to the tumorigenic effects of asbestos and suggest that high penetrance of mesothelioma requires such environmental exposure.
Cx32 (show GJB1 ELISA Kits) expression is in part related to induction of tight junctions through modulation of Magi1 (show CNKSR3 ELISA Kits) expression in an immortalized hepatic cell line.
ARIP1 (show MAGI2 ELISA Kits) and ARIP2 (show SYNJ2BP ELISA Kits) are co-expressed in some nerve cells and their biological activities are distinct.
results identify a potent tumor suppressor function for BAP1 in myeloid neoplasia; propose that BAP1 forms a core complex with HCF-1 (show HCFC1 ELISA Kits) and OGT (show OGT ELISA Kits) that can differentially recruit additional histone-modifying enzymes to regulate gene expression and preserve norm
A deleterious mutation of BAP1 (show RNF2 ELISA Kits) was confirmed in 12/17 melanocytic BAP1 (show RNF2 ELISA Kits)-associated intradermal tumors cases.
Although there have been reports of sarcomas and meningiomas in patients affected with BAP1 (show RNF2 ELISA Kits) mutations, to our knowledge malignant peripheral nerve sheath tumors in this patient population have not been previously reported. We report a case of malignant peripheral nerve sheath tumor in a patient affected by a BAP1 (show RNF2 ELISA Kits) mutation.
Low BAP1 (show RNF2 ELISA Kits) expression is associated with lung cancer progression.
Study shows that the tumor suppressor gene breast cancer [BRCA]1-associated protein 1 (BAP1 (show RNF2 ELISA Kits)) is inactivated in 6 high-grade, rhabdoid meningiomas. In addition to patients with somatic BAP1 (show RNF2 ELISA Kits) loss, 2 patients carried germline mutations, indicating that such meningiomas can arise as part of the BAP1 (show RNF2 ELISA Kits) cancer predisposition syndrome.
Nine of the 32 (28.1%) iCCA patients had gene mutations at chromosome 3p, totaling 11 mutations across five genes. Those included five (15.6%) BAP1 (show RNF2 ELISA Kits) mutations, two each (6.3%) of CACNA2D3 (show CACNA2D3 ELISA Kits) and RASSF1 (show RASSF1 ELISA Kits) mutations, and one each (3.1%) of ATG7 (show ATG7 ELISA Kits) and PLCD1 (show PLCD1 ELISA Kits) mutations. Six (18.8%) cases had concurrent loss of chromosome 3p and gene mutations.
BAP1 (show RNF2 ELISA Kits) mutation, Copy Number Loss, and/or Loss of Protein Expression is associated with Malignant Peritoneal Mesotheliomas.
BAP1 (show RNF2 ELISA Kits) regulates IP3R3 (show ITPR3 ELISA Kits)-mediated Ca(2 (show CA2 ELISA Kits)+) flux to mitochondria suppressing cell transformation
Loss of BAP1 (show RNF2 ELISA Kits) expression is associated with lung adenocarcinoma.
Our data confirm the established role of BAP1 as a tumor suppressor protein and is the first report where BAP1 has been studied in pT1 clear cell renal cell carcinomas
Important role of BAP1 (show RNF2 ELISA Kits) in the survival of osteosarcoma cells.
The protein encoded by this gene localizes to the nucleus and it interacts with the RING finger domain of the breast cancer 1, early onset protein (BRCA1). This gene is thought to be a tumor suppressor gene that functions in the BRCA1 growth control pathway. There are multiple polyadenylation sites found in this gene.
BRCA1-associated protein 1
, ubiquitin C-terminal hydrolase X4
, ubiquitin carboxyl-terminal hydrolase BAP1
, cerebral protein 6
, cerebral protein-13
, Brca1 associated protein 1
, BAI1-associated protein 3
, ubiquitin carboxy-terminal hydrolase
, BAI1-associated protein 1
, guanylate kinase membrane-associated inverted 1
, membrane-associated guanylate kinase inverted 1
, membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1