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BRCC3 encodes a subunit of the BRCA1-BRCA2-containing complex (BRCC), which is an E3 ubiquitin ligase. Additionally we are shipping BRCA1/BRCA2-Containing Complex, Subunit 3 Proteins (10) and BRCA1/BRCA2-Containing Complex, Subunit 3 Kits (4) and many more products for this protein.
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Human Monoclonal BRCC3 Primary Antibody for EIA, IHC (p) - ABIN400864
Chen, Arciero, Wang, Broccoli, Godwin: BRCC36 is essential for ionizing radiation-induced BRCA1 phosphorylation and nuclear foci formation. in Cancer research 2006
Show all 3 references for ABIN400864
Human Polyclonal BRCC3 Primary Antibody for IHC, ELISA - ABIN1001938
Dong, Hakimi, Chen, Kumaraswamy, Cooch, Godwin, Shiekhattar: Regulation of BRCC, a holoenzyme complex containing BRCA1 and BRCA2, by a signalosome-like subunit and its role in DNA repair. in Molecular cell 2003
Show all 2 references for ABIN1001938
BRCC3 inversely correlated with NPC (show NPC1 Antibodies) overall and relapse-free survival. Its expression was higher in radioresistant NPC (show NPC1 Antibodies) cells, where BRCC3 knockdown increased the cell survival fraction, attenuated DNA damage repair and resulted in G2/M cell cycle arrest.
BRCC3 likely plays a role as tumor-associated gene in myelodysplastic syndromes and myelodysplastic/myeloproliferative neoplasms.
KIAA0157 (show FAM175B Antibodies) allosterically activates a cognate deubiquitinating enzyme (DUB) partner and implicates super dimerization as a new regulatory mechanism underlying BRCC36 DUB activity.
upregulation of BRCC3 expression is associated with glioma.
these data strongly suggest that BRCC3, a deubiquitinating enzyme that is part of the cellular BRCA1 and BRISC complexes, is an important player in angiogenesis and that BRCC3 loss-of-function mutations are associated with moyamoya angiopathy.
NBA1/MERIT40 (show BABAM1 Antibodies) and BRE (show BRE Antibodies) interaction is required for the integrity of two distinct deubiquitinating enzyme BRCC36-containing complexes
scaffold proteins not only participate in the regulation of BRCC36 activity but also determine its subcellular localization and cellular functions.
These findings demonstrate that BRCC3 is a novel effector of Raf-1 (show RAF1 Antibodies), and implicate a role of BRCC3 in modulation of p-ERK (show EPHB2 Antibodies), cell survival and proliferation.
the human Ubc13 (show UBE2N Antibodies)/Rnf8 (show RNF8 Antibodies) ubiquitin ligases control foci formation of the Rap80 (show UIMC1 Antibodies)/Abraxas/Brca1/Brcc36 complex in response to DNA damage
Specificity for K63-linked polyubiquitin (show UBB Antibodies) is a common property of the JAMM/MPN (show PRSS27 Antibodies)+ family of deubiquitinating enzymes.
The deubiquitinating enzyme, BRCC3, is a critical regulator of NLRP3 (show NLRP3 Antibodies) activity by promoting its deubiquitination.
This gene encodes a subunit of the BRCA1-BRCA2-containing complex (BRCC), which is an E3 ubiquitin ligase. This complex plays a role in the DNA damage response, where it is responsible for the stable accumulation of BRCA1 at DNA break sites. The component encoded by this gene can specifically cleave Lys 63-linked polyubiquitin chains, and it regulates the abundance of these polyubiquitin chains in chromatin. The loss of this gene results in abnormal angiogenesis and is associated with syndromic moyamoya, a cerebrovascular angiopathy. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 5.
BRCA1/BRCA2-containing complex, subunit 3
, BRCA1-A complex subunit BRCC36
, BRCA1/BRCA2-containing complex subunit 3
, BRCA1/BRCA2-containing complex subunit 36
, BRISC complex subunit BRCC36
, lys-63-specific deubiquitinase BRCC36
, 6.1A protein