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anti-BRCA1/BRCA2-Containing Complex, Subunit 3 (BRCC3) Antibodies

BRCC3 encodes a subunit of the BRCA1-BRCA2-containing complex (BRCC), which is an E3 ubiquitin ligase. Additionally we are shipping BRCA1/BRCA2-Containing Complex, Subunit 3 Proteins (10) and BRCA1/BRCA2-Containing Complex, Subunit 3 Kits (4) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
BRCC3 79184 P46736
BRCC3 210766 P46737
BRCC3 316794 B2RYM5
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Top anti-BRCA1/BRCA2-Containing Complex, Subunit 3 Antibodies at antibodies-online.com

Showing 10 out of 100 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Mouse Un-conjugated EIA, IHC (p), WB 0.1 mL Log in to see 6 to 8 Days
$412.50
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB Immunohistochemistry of BRCC36 in human brain tissue with BRCC36 antibody at 2.5 μg/ml. Western blot analysis of BRCC36 in MCF7 cell lysate with AP30164PU-N BRCC36 antibody at (A) 0.5, (B) 1 and (C) 2 μg/ml. 0.1 mg Log in to see 6 to 8 Days
$401.50
Details
Human Rabbit Un-conjugated IHC (p), WB 0.1 mg Log in to see 6 to 8 Days
$412.50
Details
Human Rabbit Un-conjugated IF, WB Host: Rabbit  Target Name: BRCC3  Sample Tissue: Human Hela  Antibody Dilution: 1.0 µg/mL BRCC3 is strongly supported by BioGPS gene expression data to be expressed in Human HeLa cells 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Mouse Un-conjugated IHC (p), ELISA, WB Human Spleen (formalin-fixed, paraffin-embedded) stained with  antibody ABIN462274 followed by biotinylated secondary antibody, alkaline phosphatase-streptavidin and chromogen. Human Kidney (formalin-fixed, paraffin-embedded) stained with  antibody ABIN462274 followed by biotinylated secondary antibody, alkaline phosphatase-streptavidin and chromogen. 50 μL Log in to see 8 to 10 Days
$451.00
Details
Human Rabbit Un-conjugated IHC (p), WB Human Skeletal Muscle (formalin-fixed, paraffin-embedded) stained with BRCC3 antibody ABIN213911 at 5 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody ABIN481713, alkaline phosphatase-streptavidin and chromogen. Human Kidney (formalin-fixed, paraffin-embedded) stained with BRCC3 antibody ABIN213911 at 5 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody ABIN481713, alkaline phosphatase-streptavidin and chromogen. 50 μg Log in to see 8 to 10 Days
$451.00
Details
Human Rabbit Un-conjugated IHC (p), WB 50 μg Log in to see 6 to 8 Days
$500.50
Details
Human Mouse Un-conjugated IHC, ELISA, WB 0.05 mL Log in to see 2 to 3 Days
$481.25
Details
Human Rabbit Un-conjugated IHC, ELISA, WB   100 μg Log in to see 15 to 19 Days
$455.07
Details

BRCC3 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-BRCA1/BRCA2-Containing Complex, Subunit 3 Antibodies

  1. Human Monoclonal BRCC3 Primary Antibody for EIA, IHC (p) - ABIN400864 : Chen, Arciero, Wang, Broccoli, Godwin: BRCC36 is essential for ionizing radiation-induced BRCA1 phosphorylation and nuclear foci formation. in Cancer research 2006 (PubMed)
    Show all 3 references for ABIN400864

  2. Human Polyclonal BRCC3 Primary Antibody for IHC, ELISA - ABIN1001938 : Dong, Hakimi, Chen, Kumaraswamy, Cooch, Godwin, Shiekhattar: Regulation of BRCC, a holoenzyme complex containing BRCA1 and BRCA2, by a signalosome-like subunit and its role in DNA repair. in Molecular cell 2003 (PubMed)
    Show all 2 references for ABIN1001938

More Antibodies against BRCA1/BRCA2-Containing Complex, Subunit 3 Interaction Partners

Human BRCA1/BRCA2-Containing Complex, Subunit 3 (BRCC3) interaction partners

  1. BRCC3 inversely correlated with NPC (show NPC1 Antibodies) overall and relapse-free survival. Its expression was higher in radioresistant NPC (show NPC1 Antibodies) cells, where BRCC3 knockdown increased the cell survival fraction, attenuated DNA damage repair and resulted in G2/M cell cycle arrest.

  2. BRCC3 likely plays a role as tumor-associated gene in myelodysplastic syndromes and myelodysplastic/myeloproliferative neoplasms.

  3. KIAA0157 (show FAM175B Antibodies) allosterically activates a cognate deubiquitinating enzyme (DUB) partner and implicates super dimerization as a new regulatory mechanism underlying BRCC36 DUB activity.

  4. upregulation of BRCC3 expression is associated with glioma.

  5. these data strongly suggest that BRCC3, a deubiquitinating enzyme that is part of the cellular BRCA1 and BRISC complexes, is an important player in angiogenesis and that BRCC3 loss-of-function mutations are associated with moyamoya angiopathy.

  6. NBA1/MERIT40 (show BABAM1 Antibodies) and BRE (show BRE Antibodies) interaction is required for the integrity of two distinct deubiquitinating enzyme BRCC36-containing complexes

  7. scaffold proteins not only participate in the regulation of BRCC36 activity but also determine its subcellular localization and cellular functions.

  8. These findings demonstrate that BRCC3 is a novel effector of Raf-1 (show RAF1 Antibodies), and implicate a role of BRCC3 in modulation of p-ERK (show EPHB2 Antibodies), cell survival and proliferation.

  9. the human Ubc13 (show UBE2N Antibodies)/Rnf8 (show RNF8 Antibodies) ubiquitin ligases control foci formation of the Rap80 (show UIMC1 Antibodies)/Abraxas/Brca1/Brcc36 complex in response to DNA damage

  10. Specificity for K63-linked polyubiquitin (show UBB Antibodies) is a common property of the JAMM/MPN (show PRSS27 Antibodies)+ family of deubiquitinating enzymes.

Mouse (Murine) BRCA1/BRCA2-Containing Complex, Subunit 3 (BRCC3) interaction partners

  1. The deubiquitinating enzyme, BRCC3, is a critical regulator of NLRP3 (show NLRP3 Antibodies) activity by promoting its deubiquitination.

BRCA1/BRCA2-Containing Complex, Subunit 3 (BRCC3) Antigen Profile

Protein Summary

This gene encodes a subunit of the BRCA1-BRCA2-containing complex (BRCC), which is an E3 ubiquitin ligase. This complex plays a role in the DNA damage response, where it is responsible for the stable accumulation of BRCA1 at DNA break sites. The component encoded by this gene can specifically cleave Lys 63-linked polyubiquitin chains, and it regulates the abundance of these polyubiquitin chains in chromatin. The loss of this gene results in abnormal angiogenesis and is associated with syndromic moyamoya, a cerebrovascular angiopathy. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 5.

Gene names and symbols associated with BRCC3

  • BRCA1/BRCA2-containing complex, subunit 3 (BRCC3) antibody
  • DEP domain containing 1B (depdc1b) antibody
  • BRCA1/BRCA2-containing complex, subunit 3 (LOC100339276) antibody
  • BRCA1/BRCA2-containing complex subunit 3 (brcc3) antibody
  • BRCA1/BRCA2-containing complex, subunit 3 (Brcc3) antibody
  • BRCA1/BRCA2-containing complex, subunit 3 (BRCC36) antibody
  • BRCA1/BRCA2-containing complex, subunit 3 (brcc3) antibody
  • brcc3 antibody
  • brcc36 antibody
  • C6.1A antibody
  • CXorf53 antibody
  • xtp1 antibody

Protein level used designations for BRCC3

BRCA1/BRCA2-containing complex, subunit 3 , c6.1A , BRCA1-A complex subunit BRCC36 , BRCA1/BRCA2-containing complex subunit 3 , BRCA1/BRCA2-containing complex subunit 36 , BRISC complex subunit BRCC36 , lys-63-specific deubiquitinase BRCC36 , 6.1A protein

GENE ID SPECIES
422201 Gallus gallus
465951 Pan troglodytes
612642 Canis lupus familiaris
702888 Macaca mulatta
100158588 Xenopus (Silurana) tropicalis
100172840 Pongo abelii
100339276 Oryctolagus cuniculus
100607439 Nomascus leucogenys
100195855 Salmo salar
79184 Homo sapiens
210766 Mus musculus
316794 Rattus norvegicus
519513 Bos taurus
100516948 Sus scrofa
447688 Xenopus laevis
Selected quality suppliers for anti-BRCA1/BRCA2-Containing Complex, Subunit 3 (BRCC3) Antibodies
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