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BRCA1/BRCA2-Containing Complex, Subunit 3 Proteins (BRCC3)

BRCC3 encodes a subunit of the BRCA1-BRCA2-containing complex (BRCC), which is an E3 ubiquitin ligase. Additionally we are shipping BRCA1/BRCA2-Containing Complex, Subunit 3 Antibodies (80) and BRCA1/BRCA2-Containing Complex, Subunit 3 Kits (4) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
BRCC3 79184 P46736
BRCC3 210766 P46737
BRCC3 316794 B2RYM5
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Top BRCA1/BRCA2-Containing Complex, Subunit 3 Proteins at antibodies-online.com

Showing 10 out of 10 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His-SUMO Tag 50 μg Log in to see 21 to 26 Days
$341.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast REACT_Atlantic Salmon His tag   1 mg Log in to see 56 to 66 Days
$2,673.00
Details
Yeast Xenopus tropicalis His tag   1 mg Log in to see 56 to 66 Days
$2,674.83
Details
Yeast Xenopus laevis His tag   1 mg Log in to see 56 to 66 Days
$2,674.83
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$2,764.67
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$2,843.50
Details
Yeast Callithrix jacchus His tag   1 mg Log in to see 56 to 66 Days
$2,843.50
Details

BRCC3 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
, ,
Mouse (Murine)

Rat (Rattus)

More Proteins for BRCA1/BRCA2-Containing Complex, Subunit 3 (BRCC3) Interaction Partners

Human BRCA1/BRCA2-Containing Complex, Subunit 3 (BRCC3) interaction partners

  1. BRCC3 inversely correlated with NPC (show NPC1 Proteins) overall and relapse-free survival. Its expression was higher in radioresistant NPC (show NPC1 Proteins) cells, where BRCC3 knockdown increased the cell survival fraction, attenuated DNA damage repair and resulted in G2/M cell cycle arrest.

  2. BRCC3 likely plays a role as tumor-associated gene in myelodysplastic syndromes and myelodysplastic/myeloproliferative neoplasms.

  3. KIAA0157 (show FAM175B Proteins) allosterically activates a cognate deubiquitinating enzyme (DUB) partner and implicates super dimerization as a new regulatory mechanism underlying BRCC36 DUB activity.

  4. upregulation of BRCC3 expression is associated with glioma.

  5. these data strongly suggest that BRCC3, a deubiquitinating enzyme that is part of the cellular BRCA1 and BRISC complexes, is an important player in angiogenesis and that BRCC3 loss-of-function mutations are associated with moyamoya angiopathy.

  6. NBA1/MERIT40 (show BABAM1 Proteins) and BRE (show BRE Proteins) interaction is required for the integrity of two distinct deubiquitinating enzyme BRCC36-containing complexes

  7. scaffold proteins not only participate in the regulation of BRCC36 activity but also determine its subcellular localization and cellular functions.

  8. These findings demonstrate that BRCC3 is a novel effector of Raf-1 (show RAF1 Proteins), and implicate a role of BRCC3 in modulation of p-ERK (show EPHB2 Proteins), cell survival and proliferation.

  9. the human Ubc13 (show UBE2N Proteins)/Rnf8 (show RNF8 Proteins) ubiquitin ligases control foci formation of the Rap80 (show UIMC1 Proteins)/Abraxas/Brca1/Brcc36 complex in response to DNA damage

  10. Specificity for K63-linked polyubiquitin (show UBB Proteins) is a common property of the JAMM/MPN (show PRSS27 Proteins)+ family of deubiquitinating enzymes.

Mouse (Murine) BRCA1/BRCA2-Containing Complex, Subunit 3 (BRCC3) interaction partners

  1. The deubiquitinating enzyme, BRCC3, is a critical regulator of NLRP3 (show NLRP3 Proteins) activity by promoting its deubiquitination.

BRCA1/BRCA2-Containing Complex, Subunit 3 (BRCC3) Protein Profile

Protein Summary

This gene encodes a subunit of the BRCA1-BRCA2-containing complex (BRCC), which is an E3 ubiquitin ligase. This complex plays a role in the DNA damage response, where it is responsible for the stable accumulation of BRCA1 at DNA break sites. The component encoded by this gene can specifically cleave Lys 63-linked polyubiquitin chains, and it regulates the abundance of these polyubiquitin chains in chromatin. The loss of this gene results in abnormal angiogenesis and is associated with syndromic moyamoya, a cerebrovascular angiopathy. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 5.

Gene names and symbols associated with BRCC3

  • BRCA1/BRCA2-containing complex, subunit 3 (BRCC3)
  • DEP domain containing 1B (depdc1b)
  • BRCA1/BRCA2-containing complex, subunit 3 (LOC100339276)
  • BRCA1/BRCA2-containing complex subunit 3 (brcc3)
  • BRCA1/BRCA2-containing complex, subunit 3 (Brcc3)
  • BRCA1/BRCA2-containing complex, subunit 3 (BRCC36)
  • BRCA1/BRCA2-containing complex, subunit 3 (brcc3)
  • brcc3 protein
  • brcc36 protein
  • C6.1A protein
  • CXorf53 protein
  • xtp1 protein

Protein level used designations for BRCC3

BRCA1/BRCA2-containing complex, subunit 3 , c6.1A , BRCA1-A complex subunit BRCC36 , BRCA1/BRCA2-containing complex subunit 3 , BRCA1/BRCA2-containing complex subunit 36 , BRISC complex subunit BRCC36 , lys-63-specific deubiquitinase BRCC36 , 6.1A protein

GENE ID SPECIES
422201 Gallus gallus
465951 Pan troglodytes
612642 Canis lupus familiaris
702888 Macaca mulatta
100158588 Xenopus (Silurana) tropicalis
100172840 Pongo abelii
100339276 Oryctolagus cuniculus
100607439 Nomascus leucogenys
100195855 Salmo salar
79184 Homo sapiens
210766 Mus musculus
316794 Rattus norvegicus
519513 Bos taurus
100516948 Sus scrofa
447688 Xenopus laevis
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