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BRISC and BRCA1 A Complex Member 1 Proteins (BABAM1)

Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). Additionally we are shipping BRISC and BRCA1 A Complex Member 1 Antibodies (37) and BRISC and BRCA1 A Complex Member 1 Kits (4) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
BABAM1 29086 Q9NWV8
BABAM1 68251 Q3UI43
Rat BABAM1 BABAM1 290631 Q5XIJ6
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Top BRISC and BRCA1 A Complex Member 1 Proteins at antibodies-online.com

Showing 8 out of 9 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Xenopus tropicalis His tag   1 mg Log in to see 56 to 66 Days
$2,852.67
Details
Yeast Callithrix jacchus His tag   1 mg Log in to see 56 to 66 Days
$2,887.50
Details
Yeast Pongo abelii His tag   1 mg Log in to see 56 to 66 Days
$2,887.50
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 3 to 4 Days
$510.36
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

BABAM1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

More Proteins for BRISC and BRCA1 A Complex Member 1 (BABAM1) Interaction Partners

Human BRISC and BRCA1 A Complex Member 1 (BABAM1) interaction partners

  1. MERIT40 interacts with ABRAXAS which is adaptor molecule of BRCA1-complex.

  2. findings suggest that germline deleterious mutations in C19orf62 should be rare or absent in familial and nonfamilial breast cancer women

  3. NBA1/MERIT40 and BRE (show BRE Proteins) interaction is required for the integrity of two distinct deubiquitinating enzyme BRCC36 (show BRCC3 Proteins)-containing complexes

  4. Single nucleotide polymorphism in MERIT40 is associated with ovarian cancer.

  5. germline mutations in MERIT40 are rare or absent in familial breast cancer patients.

  6. MERIT40 represents a novel factor that links BRCA1-Rap80 complex integrity, DSB recognition, and ubiquitin chain hydrolytic activities to the DNA damage response.

  7. A stable complex containing MERIT40 acts early in DNA damage response and regulates damage-dependent BRCA1 localization.

  8. NBA1 is required to maintain BRE and Abra1 abundance and for the recruitment of BRCA1 to sites of DNA damage. In depth bioinformatics analysis revealed that the BRCA1 A complex bears striking similarities to the 19S proteasome complex.

Mouse (Murine) BRISC and BRCA1 A Complex Member 1 (BABAM1) interaction partners

  1. Merit40 mutation exacerbated ICL-induced chromosome instability in the context of concomitant Brca2 deficiency but not in conjunction with Fancd2 mutation.

  2. MERIT40(-/-) hematopoietic stem cells are more resistant to cytoablative stress, and exhibit superior repopulating ability and self-renewal upon serial transplantation.

BRISC and BRCA1 A Complex Member 1 (BABAM1) Protein Profile

Protein Summary

Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. Probably also plays a role as a component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin. In these 2 complexes, it is probably required to maintain the stability of BRE/BRCC45 and help the 'Lys-63'-linked deubiquitinase activity mediated by BRCC3/BRCC36. component (By similarity).

Gene names and symbols associated with BABAM1

  • BRISC and BRCA1 A complex member 1 (babam1)
  • BRISC and BRCA1 A complex member 1 (BABAM1)
  • BRISC and BRCA1 A complex member 1 (Babam1)
  • 5430437P03Rik protein
  • C7H19orf62 protein
  • C19orf62 protein
  • Merit40 protein
  • NBA1 protein
  • zgc:100909 protein

Protein level used designations for BABAM1

BRCA1-A complex subunit MERIT40 , BRISC and BRCA1-A complex member 1 , mediator of RAP80 interactions and targeting subunit of 40 kDa , new component of the BRCA1-A complex , mediator of Rap80 interactions and targeting 40 kDa , new component of the BRCA1 A complex , new component of the BRCAA1 A complex , Uncharacterized protein C19orf62 homolog

GENE ID SPECIES
445296 Danio rerio
496740 Xenopus (Silurana) tropicalis
29086 Homo sapiens
444814 Xenopus laevis
504517 Bos taurus
68251 Mus musculus
290631 Rattus norvegicus
100173294 Pongo abelii
100395309 Callithrix jacchus
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