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BACH1 encodes a transcription factor that belongs to the cap'n'collar type of basic region leucine zipper factor family (CNC-bZip). Additionally we are shipping BACH1 Antibodies (101) and BACH1 Kits (2) and many more products for this protein.
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Bach1 regulates the liver specificity and transience of the Nrf2a (show NFE2L2 Proteins)-dependent induction of hmox1a and that heme mediates this regulation through Bach1 inhibition based on its level in each tissue.
The Bach1b-MafK heterodimer represses the zymogen promoters, whereas the Nrf2a-MafK heterodimer activates them.
Bach1 deficiency reduces the severity of osteoarthritis-like changes. This may be due to maintenance of cartilage homeostasis and joint health by antioxidant effects
Bach1 suppresses angiogenesis after ischemic injury and impairs Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling by disrupting the interaction between beta-catenin (show CTNNB1 Proteins) and TCF4 (show TCF4 Proteins) and by recruiting histone deacetylase 1 (show HDAC1 Proteins) to the promoter of TCF4 (show TCF4 Proteins)-targeted genes.
Bach1 deficiency and accompanying overexpression of HO-1 (show HMOX1 Proteins) did not influence aging or p53 (show TP53 Proteins) deficiency-driven tumorigenesis.
Our results suggest that Bach2 (show BACH2 Proteins) functions with Bach1 and EBF1 (show EBF1 Proteins) to promote B cell development by repressing myeloid genes in common lymphoid progenitor cells
HO-1 (show HMOX1 Proteins) induction after ischemia was associated to down-regulation of transcriptional repressor Bach-1, and induction of HO-1 (show HMOX1 Proteins) when HO enzymatic activity was inhibited was related to worst outcome after brain ischemia.
Bach1 deficiency ameliorates TNBS colitis.
Our data provide evidence for a critical role of Bach1 in cell transformation and tumor growth induced by activated H-Ras (show HRAS Proteins)(V12).
apoptosis rate was significantly lower at 1 and 2 weeks post-puncture in Bach 1-/- mice
Transcriptional network analysis identifies BACH1 as a master regulator of breast cancer bone metastasis
Loss of Bach1 is associated with impaired APC (show APC Proteins) development accompanied by defects in downstream T-cell responses and partial protection from experimental autoimmune encephalomyelitis.
heme oxygenase-1 (show HMOX1 Proteins) expression is induced by gold nanoparticles through Nrf2 (show GABPA Proteins) activation and Bach1 export in human vascular endothelial cells
Cyanidin-3-O-glucoside protects HUVECs from palmitic acid-induced injuryby modulating the balance of Nrf2 (show GABPA Proteins) versus Bach1 inside the nucleus so influencing upregulation of electrophile responsive element mediated gene expression.
sensitizer-induced up-regulation of both the endogenous HMOX1 (show HMOX1 Proteins) and the luciferase constructs under the control of the HMOX1 (show HMOX1 Proteins)-ARE or the full HMOX1 (show HMOX1 Proteins) promoter appear to be under the control of both Nrf2 (show GABPA Proteins) and Bach1.
This study demonstrated that Bach1 overexpression in Down syndrome correlates with the alteration of the HO-1 (show HMOX1 Proteins)/BVR-a (show BLVRA Proteins) system.
Higher HMOX1 (show HMOX1 Proteins) expression correlated with higher expression of Bach-1 (Spearman's rho = 0.586, p = 0.000001) and miR (show MLXIP Proteins)-122 (Spearman's rho = 0.270, p = 0.014059).
The Bach1-dependent repression of the HO-1 (show HMOX1 Proteins) expression is under the control of the Hx-dependent uptake of extracellular heme
The arsenic-induced Nrf2 (show GABPA Proteins) pathway activation in hepatocytes suggested that the translocation of Bach1 was associated with the regulation of Nrf2 (show GABPA Proteins) pathway by arsenic.
In colorectal cancer, Nrf2 (show GABPA Proteins) expression is closely correlated with Keap1 (show KEAP1 Proteins) in the tumor and with Bach1 in the normal tissue.
CXCR3 (show CXCR3 Proteins)-B mediates a growth-inhibitory signal in breast cancer cells through the modulations of nuclear translocation of Bach-1 and Nrf2 (show GABPA Proteins) and down-regulation of HO-1 (show HMOX1 Proteins).
This gene encodes a transcription factor that belongs to the cap'n'collar type of basic region leucine zipper factor family (CNC-bZip). The encoded protein contains broad complex, tramtrack, bric-a-brac/poxvirus and zinc finger (BTB/POZ) domains, which is atypical of CNC-bZip family members. These BTB/POZ domains facilitate protein-protein interactions and formation of homo- and/or hetero-oligomers. When this encoded protein forms a heterodimer with MafK, it functions as a repressor of Maf recognition element (MARE) and transcription is repressed. Multiple alternatively spliced transcript variants have been identified for this gene.
BTB and CNC homology 1 transcription factor
, BTB and CNC homology 1, basic leucine zipper transcription factor 1
, basic leucine zipper transcription factor 1
, transcription regulator protein BACH1-like
, BTB and CNC homolog 1
, transcription regulator protein BACH1
, basic region leucine zipper transcriptional regulator BACH1