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Transcriptional regulator that acts as repressor or activator. Additionally we are shipping BACH2 Proteins (5) and many more products for this protein.
Showing 10 out of 74 products:
Human Polyclonal BACH2 Primary Antibody for EIA, FACS - ABIN950597
Dubois, Trynka, Franke, Hunt, Romanos, Curtotti, Zhernakova, Heap, Adány, Aromaa, Bardella, van den Berg, Bockett, de la Concha, Dema, Fehrmann, Fernández-Arquero, Fiatal, Grandone, Green, Groen et al.: Multiple common variants for celiac disease influencing immune gene expression. ... in Nature genetics 2010
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Human Polyclonal BACH2 Primary Antibody for EIA, WB - ABIN950596
Pierce, Ahsan: Genetic susceptibility to type 2 diabetes is associated with reduced prostate cancer risk. in Human heredity 2010
Show all 3 references for 950596
Cow (Bovine) Polyclonal BACH2 Primary Antibody for WB - ABIN2777818
Hong, Kim, Lee: The role of Bach2 in nucleic acid-triggered antiviral innate immune responses. in Biochemical and biophysical research communications 2007
BACH2 downregulation contributes to constitutive activation of the nuclear factor-kappaB.
BACH2 haploinsufficiency causing a syndrome of immune deficiency and autoimmunity is described in two families. Affected subjects had lymphocyte-maturation defects that caused immunoglobulin deficiency and intestinal inflammation.
In this study silencing BACH2 in mantle cell lymphoma cells resulted in increased proliferation and enhanced tumor dispersal in hypoxic microenvironments, suggesting a tumor suppressor-like role of BACH2.
we developed a CRISPR-Cas9-based tool for specific DNA methylation (show HELLS PLURAL_@2410@) consisting of deactivated Cas9 (dCas9) nuclease (show DCLRE1C PLURAL_@2410@) and catalytic domain of the DNA methyltransferase (show DNMT1 PLURAL_@2410@) DNMT3A (show DNMT3A PLURAL_@2410@) targeted by co-expression of a guide RNA to any 20 bp DNA sequence followed by the NGG trinucleotide.we demonstrated that directed DNA methylation (show HELLS PLURAL_@2410@) of a wider promoter region of the target loci IL6ST (show IL6ST PLURAL_@2410@) and BACH2 decreased their expression
genetic association studies in population in the United Kingdom: Data suggest that an SNP in BACH2 (rs3757247) is associated with autoimmune Addison's disease and with polyglandular autoimmune syndrome type 2. These findings were replicated in a Norwegian validation cohort.
The shift in the CSDs by heme binding suggested that heme binding causes Bach2(331-520) to adopt a more compact conformation. In addition, heme binding to the CP-motif could reduce the flexibility of Bach2(331-520) Consequently, the five-coordinated heme binding destabilizes Bach2(331-520), by reducing the flexibility of the polypeptide chain.
The study identifies a strong association of Coeliac Disease with a network of BACH2 regulated genes, supporting emerging evidence of an important role of BACH2 in the regulation of T cell differentiation and prevention of autoimmune disease.
The investigated Bach2 gene polymorphisms (rs11755527, rs3757247, rs12212193 and rs2474619) are not related to the susceptibility to either Vogt-Koyanagi-Harada syndrome and Behcet's disease in our investigated Chinese Han population.
Gene expression analysis revealed that three gene BACH2, PTGER4 (show PTGER4 Antibodies) and ZFP36L1 (show ZFP36L1 Antibodies), are down-regulated in MS patients' blood cells compared to healthy subjects.
These observations suggested that the unstructured region of Bach2 is important for heme binding, and consequently for its functional regulation
Data show that B-cell tumour suppressor BTB and CNC homology 2 (Bach2) was significantly downregulated by the loss of NF-kappaB (show NFKB1 Antibodies) subunit proto-oncogene (show RAB1A Antibodies) protein c (show PROC Antibodies)-rel (c-Rel (show NFkBP65 Antibodies)) .
this study shows that the transcription factor BACH2 promotes memory CD8 (show CD8A Antibodies)+ T cell generation by blocking access to genomic regulatory sites recognized by AP-1 (show JUN Antibodies)
this study shows that B cells of lower affinity receive weaker T cell help, which results in higher expression of the transcriptional repressor Bach2 and promotes the development of memory B cells
Bach2 controls homeostasis of eosinophils via restricting the production of Il-5 (show IL5 Antibodies) in CD4 (show CD4 Antibodies)(+) T cells.
These results suggest that Bach1 (show BACH1 Antibodies) and Bach2 work in a complementary manner to maintain the normal function of the AMs (show MAT1A Antibodies) and surfactant homeostasis in the lung.
these data also showed that mouse Bach2 mRNA was a novel target of miR (show MLXIP Antibodies)-30b.
PI3K-Akt (show AKT1 Antibodies)-mTOR (show FRAP1 Antibodies) pathway inhibits Bach2 by both repressing its expression and inducing its phosphorylation in B cells.
Bach2 is suggested to cooperate with HDAC3 (show HDAC3 Antibodies)-containing co-repressor complexes in B cells to regulate the stage-specific expression of Prdm1 (show PRDM1 Antibodies) by writing epigenetic modifications at the Prdm1 (show PRDM1 Antibodies) locus.
These findings demonstrate that BACH2 is a key component of the molecular program of tumor immunosuppression and identify therapeutic targets for the reversal of immunosuppression in cancer.
Transcriptional regulator that acts as repressor or activator. Binds to Maf recognition elements (MARE). Play important roles in coordinating transcription activation and repression by MAFK (By similarity).
transcription regulator protein BACH2
, BTB and CNC homology 2
, BTB and CNC homology 1, basic leucine zipper transcription factor 2
, transcription regulator protein BACH2-like
, BTB and CNC homolog 2
, Transcription regulator protein BACH2 (BTB and CNC homolog 2)