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The protein encoded by BIRC7 is a member of the family of inhibitor of apoptosis proteins (IAP) and contains a single copy of a baculovirus IAP repeat (BIR) as well as a RING-type zinc finger domain. Additionally we are shipping Baculoviral IAP Repeat-Containing 7 Antibodies (169) and Baculoviral IAP Repeat-Containing 7 Proteins (18) and many more products for this protein.
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Data showed that Livin knock-down suppressed cell proliferation and inhibited cell invasion, accompanied by downregulation of VEGF (show VEGFA ELISA Kits) and MMP-2 (show MMP2 ELISA Kits)/-9. Its silencing resulted in the prevention of xenograft tumor formation.
Birc7 is a late fiber gene of the mouse lens. Its expression in cells bordering the OFZ is consistent with a role in organelle degradation, a process in which the ubiquitin proteasome pathway has been implicated previously.
ML-IAP is dispensable for both normal mouse development and ocular homoeostasis.
Positive BIRC7 expression and negative KLF4 (show KLF4 ELISA Kits) expression are associated with the progression of PDAC and poor prognosis in patients with PDAC.
High expression of BIRC7 is associated with drug resistance in Renal cell carcinoma.
Data show that cylindromatosis (CYLD (show CYLD ELISA Kits)) overexpression and livin knockdown might improve gemcitabine chemosensitivity by decreasing autophagy and increasing apoptosis in bladder cancer (BCa (show BLNK ELISA Kits)) cells.
The apoptosisinducing effects of livin and surivin knockdown were investigated using a Hoechst staining kit.
Expression of livin, survivin (show BIRC5 ELISA Kits) and caspase-3 (show CASP3 ELISA Kits) are closely related to the occurrence and development of prostatic cancer.
Our results suggested the important role of Livin and its partner molecule in the process of VSV treatment
These findings suggest that livin may be used as a novel target for tumor gene therapy.
Upregulation of Livin expression and downregulation of caspase (show CASP3 ELISA Kits) activity are observed under cycling and chronic hypoxia in glioblastoma cells and xenografts.
Livin expression was higher in condyloma acuminatum than in normal cells and was correlated with survivin (show BIRC5 ELISA Kits) and Ki-67 (show MKI67 ELISA Kits).
The protein encoded by this gene is a member of the family of inhibitor of apoptosis proteins (IAP) and contains a single copy of a baculovirus IAP repeat (BIR) as well as a RING-type zinc finger domain. The BIR domain is essential for inhibitory activity and interacts with caspases, while the RING finger domain sometimes enhances antiapoptotic activity but does not inhibit apoptosis alone. Two transcript variants encoding different isoforms have been found for this gene. The two isoforms have different antiapoptotic properties, with isoform alpha protecting cells from apoptosis induced by staurosporine and isoform b protecting cells from apoptosis induced by etoposide.
baculoviral IAP repeat-containing 5-like
, baculoviral IAP repeat-containing 7
, baculoviral IAP repeat-containing 7 (livin)
, E3 ubiquitin-protein ligase EIAP
, Embryonic/Egg IAP
, baculoviral IAP repeat-containing protein 7
, RING finger protein 50
, kidney inhibitor of apoptosis protein
, livin inhibitor of apoptosis
, melanoma inhibitor of apoptosis protein