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The protein encoded by BIRC7 is a member of the family of inhibitor of apoptosis proteins (IAP) and contains a single copy of a baculovirus IAP repeat (BIR) as well as a RING-type zinc finger domain. Additionally we are shipping Baculoviral IAP Repeat-Containing 7 Antibodies (140) and Baculoviral IAP Repeat-Containing 7 Kits (7) and many more products for this protein.
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Human BIRC7 Protein expressed in Escherichia coli (E. coli) - ABIN667709
Ashhab, Alian, Polliack, Panet, Ben Yehuda: Two splicing variants of a new inhibitor of apoptosis gene with different biological properties and tissue distribution pattern. in FEBS letters 2001
Show all 2 references for ABIN667709
Data showed that Livin knock-down suppressed cell proliferation and inhibited cell invasion, accompanied by downregulation of VEGF (show VEGFA Proteins) and MMP-2 (show MMP2 Proteins)/-9. Its silencing resulted in the prevention of xenograft tumor formation.
Birc7 is a late fiber gene of the mouse lens. Its expression in cells bordering the OFZ is consistent with a role in organelle degradation, a process in which the ubiquitin proteasome pathway has been implicated previously.
ML-IAP is dispensable for both normal mouse development and ocular homoeostasis.
Our results suggested the important role of Livin and its partner molecule in the process of VSV treatment
These findings suggest that livin may be used as a novel target for tumor gene therapy.
Upregulation of Livin expression and downregulation of caspase (show CASP3 Proteins) activity are observed under cycling and chronic hypoxia in glioblastoma cells and xenografts.
Livin expression was higher in condyloma acuminatum than in normal cells and was correlated with survivin (show BIRC5 Proteins) and Ki-67 (show MKI67 Proteins).
Livin gene has a high expression in osteosarcoma and inhibits apoptosis in tumor tissue.
livin is associated with invasive and oncogenic phenotypes such as tumor cell invasion, tumor cell migration, tumor cell proliferation, and resistance to apoptosis in human oral squamous cell carcinoma cells.
These data suggest that livin overexpression plays an important role in tumor invasiveness by mediating resistance to apoptosis.
effectively silence Livin gene expression in LoVo colon cancer cells, inhibit cell proliferation and colony formation, induce apoptosis, and enhance sensitivity to cisplatin
In diagnostically difficult cases of diffuse large B-cell lymphoma and Hodgkin lymphoma, focus on livin as marker may provide useful corroborative information.
The protein encoded by this gene is a member of the family of inhibitor of apoptosis proteins (IAP) and contains a single copy of a baculovirus IAP repeat (BIR) as well as a RING-type zinc finger domain. The BIR domain is essential for inhibitory activity and interacts with caspases, while the RING finger domain sometimes enhances antiapoptotic activity but does not inhibit apoptosis alone. Two transcript variants encoding different isoforms have been found for this gene. The two isoforms have different antiapoptotic properties, with isoform alpha protecting cells from apoptosis induced by staurosporine and isoform b protecting cells from apoptosis induced by etoposide.
baculoviral IAP repeat-containing 5-like
, baculoviral IAP repeat-containing 7
, baculoviral IAP repeat-containing 7 (livin)
, E3 ubiquitin-protein ligase EIAP
, Embryonic/Egg IAP
, baculoviral IAP repeat-containing protein 7
, RING finger protein 50
, kidney inhibitor of apoptosis protein
, livin inhibitor of apoptosis
, melanoma inhibitor of apoptosis protein