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BPY2 is located in the nonrecombining portion of the Y chromosome, and expressed specifically in testis.
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genetic association study in Chinese population: Data suggest that combined patterns of copy number abnormality in BPY2 (basic charge Y-linked protein 2) and/or DAZ1 (deleted in azoospermia 1 (show DAZ1 Antibodies)) are associated with spermatogenic impairment/azoospermia.
VCY2 protein interacts with the HECT domain of ubiquitin-protein ligase E3A (show ube3a Antibodies)
VCY2 was weakly expressed at the spermatogonia and immunonegative in spermatocytes and round spermatids in testicular biopsy specimens with maturation arrest or hypospermatogenesis.
This gene is located in the nonrecombining portion of the Y chromosome, and expressed specifically in testis. The encoded protein interacts with ubiquitin protein ligase E3A and may be involved in male germ cell development and male infertility. Three nearly identical copies of this gene exist on chromosome Y\; two copies are part of a palindromic region. This record represents the copy outside of the palidromic region.
basic protein on Y chromosome 2
, testis-specific basic protein Y 2
, testis-specific basic protein on Y, 2
, variable charge, Y-linked, 2
, variably charged protein Y 2