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Basic Helix-Loop-Helix Family, Member E41 Proteins (BHLHE41)

BHLHE41 encodes a transcription factor that belongs to the Hairy/Enhancer of Split subfamily of basic helix-loop-helix factors. Additionally we are shipping BHLHE41 Antibodies (87) and BHLHE41 Kits (16) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
BHLHE41 79365 Q9C0J9
BHLHE41 79362 Q99PV5
BHLHE41 117095  
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Top BHLHE41 Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$3,138.67
Details

BHLHE41 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

Rat (Rattus)

More Proteins for Basic Helix-Loop-Helix Family, Member E41 (BHLHE41) Interaction Partners

Human Basic Helix-Loop-Helix Family, Member E41 (BHLHE41) interaction partners

  1. DEC2 is aberrantly expressed in rheumatoid arthritis tissue, it is induced by TNFalpha (show TNF Proteins) and not only affects the expression of genes belonging to molecular clock but also significantly impacts on the expression of IL-1beta (show IL1B Proteins) as well as other inflammatory genes.

  2. BHLHE40 (show BHLHE40 Proteins)/41 are promising markers to predict the aggressiveness of each Endometrial Neoplasm case and that molecular targeting strategies involving BHLHE40 (show BHLHE40 Proteins)/41 and SP1 (show PSG1 Proteins) may effectively regulate Endometrial Neoplasm progression.

  3. DEC2 facilitates HIF-1alpha (show HIF1A Proteins) stabilization and promotes HIF-1 (show HIF1A Proteins) activation in osteosarcoma.

  4. DEC2 participates in hypoxia-induced cell proliferation by functioning as a target gene of the PI3K (show PIK3CA Proteins)/Akt (show AKT1 Proteins) signaling pathway and regulating the expression of c-Myc (show MYC Proteins).

  5. SHARP1 interacted with HIF-1alpha (show HIF1A Proteins) physically.

  6. Data suggest that SHARP1 plays a critical role in tumorigenesis and acquisition of the metastatic phenotype in endometrial cancer.

  7. DEC2 regulates cellular function by modulating the expression of Twist1 (show TWIST1 Proteins)

  8. BHLHE41 mutations reduce total sleep while maintaining NREM sleep and provide resistance to the effects of sleep loss; mutations that affect sleep also modify the normal inhibition of BHLHE41 of CLOCK/BMAL1 (show ARNTL Proteins) transactivation

  9. we find high frequency of RAS mutations in t(6;11)(q27;q23) pediatric AML (show RUNX1 Proteins) and are the first to report a unique and significant differential overexpression of BHLHB3 in these patients.

  10. GLI1 (show GLI1 Proteins) expression was immunohistochemically related positively with BHLHE41 and inversely with MLH1 (show MLH1 Proteins) in PDAC cells and precancerous lesions of the pancreas.

Mouse (Murine) Basic Helix-Loop-Helix Family, Member E41 (BHLHE41) interaction partners

  1. Data show that the bHLH transcription factors SHARP1 and SHARP2 are involved in cognitive processing by controlling insulin-like growth factor II (Igf2) expression and associated signaling cascades.

  2. abnormal sleep and certain (endo)phenotypes of psychiatric diseases may be caused by common mechanisms involving components of the molecular clock including SHARP1 and SHARP2 (show BHLHE40 Proteins).

  3. SENP1 (show SENP1 Proteins) enhances adipogenesis through de-SUMOylation of Sharp-1, which then releases Sharp-1 repression of PPARgamma (show PPARG Proteins) expression and adipocyte differentiation. These results reveal SENP1 (show SENP1 Proteins) as a novel regulator in adipogenesis.

  4. DEC2 regulates cellular function by modulating the expression of Twist1 (show TWIST1 Proteins)

  5. These results demonstrate that Sharp-1 regulates muscle regenerative capacity, at least in part, by modulation of TGF-beta (show TGFB1 Proteins) signaling

  6. Data show that G9a (show EHMT2 Proteins), a lysine methyltransferase, is involved in Sharp-1-mediated inhibition of muscle differentiation.

  7. Interactions of Per1/2 and Dec2 in the regulation of period, phase, and rhythm sustainment are cell-type specific.

  8. RORalpha suppresses adipogenic differentiation at a later stage of differentiation by RORE-mediated stimulation of Dec1 (show BHLHE40 Proteins) and Dec2 expression.

  9. Results suggest a partially redundant and bidirectional regulatory function for Dec1/2 genes in transcriptional translational feedback loops and conservation of Per1-Dec synergism between vertebrate and invertebrate clocks.

  10. measured circadian locomotor behavior and clock gene expression in the SCN (show SRI Proteins) of Per2 (show PER2 Proteins)/Dec1 (show BHLHE40 Proteins)/2 double- and triple-mutant mice to analyze the functional interaction of PER2 (show PER2 Proteins) and DEC1 (show BHLHE40 Proteins)/2 feedback on circadian pacemaker function in the SCN (show SRI Proteins)

BHLHE41 Protein Profile

Protein Summary

This gene encodes a transcription factor that belongs to the Hairy/Enhancer of Split subfamily of basic helix-loop-helix factors. The encoded protein functions as a transcriptional repressor and as a regulator of molecular clock. Defects in this gene are associated with the short sleep phenotype.

Gene names and symbols associated with BHLHE41

  • basic helix-loop-helix family, member e41 (BHLHE41)
  • basic helix-loop-helix family, member e41 (bhlhe41)
  • basic helix-loop-helix family, member e41 (Bhlhe41)
  • 6430520M22Rik protein
  • Bhlhb2l protein
  • Bhlhb3 protein
  • Dec2 protein
  • hDEC2 protein
  • MGC108143 protein
  • SHARP-1 protein
  • Sharp1 protein

Protein level used designations for BHLHE41

basic helix-loop-helix domain containing, class B, 3 , basic helix-loop-helix family, member e41 , class E basic helix-loop-helix protein 41 , differentially expressed in chondrocytes protein 2 , enhancer-of-split and hairy-related protein 1 , bHLH transcriptional factor Dec2 , basic helix-loop-helix domain containing, class B3 , class B basic helix-loop-helix protein 3

GENE ID SPECIES
465351 Pan troglodytes
613096 Xenopus (Silurana) tropicalis
79365 Homo sapiens
79362 Mus musculus
117095 Rattus norvegicus
403457 Canis lupus familiaris
613907 Bos taurus
101112806 Ovis aries
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