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Basigin Proteins (BSG)

The protein encoded by BSG is a plasma membrane protein that is important in spermatogenesis, embryo implantation, neural network formation, and tumor progression.

list all proteins Gene Name GeneID UniProt
Mouse BSG BSG 12215 P18572
Human BSG BSG 682 P35613
Rat BSG BSG 25246 P26453
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More Proteins for Basigin (BSG) Interaction Partners

Fruit Fly (Drosophila melanogaster) Basigin (BSG) interaction partners

  1. Basigin promotes cytoskeletal rearrangements and the formation of lamellipodia in cultured insect cells

  2. Bsg has a role regulating synaptic compartmentalization and strength, and coordinating plasma membrane and cortical organization.

  3. Basigin expression in photoreceptor neurons is required for normal structure and placement of glia cells

  4. results suggest that the highly conserved transmembrane domain and the extracellular domains are crucial for basigin function in the visual system while the short intracellular tail may not play a role in these functions

Horse (Equine) Basigin (BSG) interaction partners

  1. The coding sequence of MCT1 (show MCTS1 Proteins), MCT4 (show SLC16A3 Proteins), and CD147 in healthy horses, and the incidence of polymorphisms of these proteins in horses with excercise-induced myopathy are reported.

  2. The levels of MCT1 (show MCTS1 Proteins) and CD147 mRNA correlated with the expression of CD147 and suggest that bimodality of their expression is regulated at transcriptional level.

  3. The expression of monocarboxylic acid transporter 1 (MCT1 (show MCTS1 Proteins)), MCT2, and CD147 in 3 horse breeds with different atheletic demands is reported.

Mouse (Murine) Basigin (BSG) interaction partners

  1. both caveolin-1 (show CAV1 Proteins) and EMMPRIN mRNA levels increased gradually with progression of developmental stages, and peaked at day two postnatal. The current finding suggests that both caveolin-1 (show CAV1 Proteins) and EMMPRIN take part in mouse tooth development, especially in the differentiation and organization of odontogenic tissues.

  2. knockdown of CD147 on Hepa1-6 cells resulted in significantly increased T cells chemotaxis induced by CypA (show PPIA Proteins) both in vivo and in vitro.

  3. These findings indicate that TGF-beta1 (show TGFB1 Proteins)-CD147 loop plays a key role in regulating the HSC (show FUT1 Proteins) activation and combination of TGF-beta (show TGFB1 Proteins) receptor inhibitor and anti-CD147 antibody might be promised to reverse fibrogenesis.

  4. Decreased CD147 expression inhibited osteoclast formation and bone resorption, inhibited RANKL (show TNFSF11 Proteins)-induced nuclear translocation of the nuclear factor of activated T cells NFATc1 (show NFATC1 Proteins).

  5. EMMPRIN promotes tumor growth and metastasis by recruitment of bone marrow-derived cells through controlling secretion and paracrine signaling of SDF-1 and VEGF.

  6. Results indicate the crucial roles of intracellular and extracellular Bsg in the pathogenesis of cardiac hypertrophy, fibrosis, and failure.

  7. Disruption of BASIGIN in tumour cells and in MEFs has no action on the production of MMPs.

  8. Extracellular CyPA (show PPIA Proteins) activates platelets via cluster of differentiation 147-mediated phosphoinositid-3-kinase/Akt (show AKT1 Proteins)-signaling, leading to enhanced adhesion and thrombus formation independently of intracellular CyPA (show PPIA Proteins)

  9. Bsg plays an indispensable role in Th17 cell differentiation as a negative regulator by suppressing the IL-6 (show IL6 Proteins)/STAT-3 (show STAT3 Proteins) pathway.

  10. may promote liver fibrosis progression via inducing the VEGF-A (show VEGFA Proteins)/VEGFR-2 (show KDR Proteins) signalling pathway-mediated cross-talk between hepatocytes and sinusoidal endothelial cells

Human Basigin (BSG) interaction partners

  1. in cultured H9C2 cells and that CyPA (show PPIA Proteins)/CD147 signaling pathway inhibition protects against Ang II (show AGT Proteins)-induced cardiomyocyte hypertrophy.

  2. CD147 was significantly upregulated in the human glioma cell lines. Downregulation of CD147 suppressed cell proliferation, blocked cell cycle, induced apoptosis, inhibited cell invasion and angiogenesis in glioma cells in vitro. CD147 was significantly associated with WHO tumor grade and angiogenesis; silencing of CD147 contributed to inhibition of glioma proliferation, invasion and angiogenesis.

  3. rs11473 polymorphism at the miR (show MLXIP Proteins)- 483-5p binding site in the 3'-UTR of basigin gene may play a key role in the development of esophageal cancer in a Chinese population.

  4. findings of this research defined a novel relationship between the down-regulation of miR (show MLXIP Proteins)-22 and the up-regulation of CD147 and demonstrated that CD147 is a downstream factor of miR (show MLXIP Proteins)-22.

  5. Triptolide represses the migration and invasion of prostate cancer cells through Cav-1 (show CAV1 Proteins)/CD147/MMPs signalling pathway.

  6. Basigin is important in vision, spermatogenesis and other physiological phenomena, and plays significant roles in the pathogenesis of numerous diseases, including cancer. Basigin is also the receptor for an invasive protein RH5, which is present in malaria parasites.

  7. The present study indicated that Slug (show SNAI2 Proteins) and EMMPRIN are potential biomarkers and therapeutic targets for the diagnosis and treatment of perineural invasion in human salivary adenoid cystic carcinoma.

  8. CD147 promoted the differentiation of Th17 cells by regulation of cytokine production, which provided the evidence for pathogenesis and potential therapeutic targets for rheumatoid arthritis.

  9. Study identified CD147 as a novel interaction partner for E2F1 (show E2F1 Proteins) and suggest a role in promoting tumor cell invasion and migration of prostate cancer cells.

  10. High BSG expression is associated with melanoma invasion and metastasis.

Rabbit Basigin (BSG) interaction partners

  1. CD147 is required for the expression of MCT1 (show MCTS1 Proteins) and MCT4 (show SLC16A3 Proteins) in the corneal endothelium. Silencing CD147 slows lactate efflux, resulting in stromal lactate accumulation and corneal edema.

Cow (Bovine) Basigin (BSG) interaction partners

  1. Data suggest that EMMPRIN derived from endometrial epithelial cells regulates expression of matrix metalloproteinases (MMP-2 (show MMP2 Proteins); MMP-14 (show MMP14 Proteins)) in endometrial stromal cells; progesterone-rich conditions stimulate expression of EMMPRIN in endometrium.

  2. The selective S-nitrosylation of EMMPRIN and GOLPH3 (show GOLPH3 Proteins) at the Golgi apparatus in endothelial cells results from the physical proximity to eNOS (show NOS3 Proteins)-derived nitric oxide.

Basigin (BSG) Protein Profile

Protein Summary

The protein encoded by this gene is a plasma membrane protein that is important in spermatogenesis, embryo implantation, neural network formation, and tumor progression. The encoded protein is also a member of the immunoglobulin superfamily. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with Basigin Proteins (BSG)

  • basigin (bsg)
  • Basigin (Bsg)
  • basigin (Bsg)
  • basigin (BSG)
  • basigin (Ok blood group) (BSG)
  • basigin (Ok blood group) (Bsg)
  • 5A11 protein
  • 5F7 protein
  • 135/10 protein
  • AI115436 protein
  • AI325119 protein
  • basignin protein
  • BcDNA:GH21853 protein
  • BSG protein
  • CD147 protein
  • CE9 protein
  • CG31605 protein
  • Dmel\\CG31605 protein
  • EMMPRIN protein
  • GB11183 protein
  • gel protein
  • HT-7 protein
  • HT7 protein
  • l(2)06243 protein
  • l(2)k06338 protein
  • l(2)k09030 protein
  • l(2)k13638 protein
  • l(2)k14308 protein
  • l(2)SH2 1217 protein
  • l(2)SH1217 protein
  • M6 protein
  • ms(2)08318 protein
  • NP6293 protein
  • OK protein
  • Ox47R protein
  • RPE7 protein
  • TCSF protein
  • wu:fb26a05 protein
  • wu:fo98e12 protein

Protein level used designations for Basigin Proteins (BSG)

5A11/Basigin-2 , cd147 , Bsg-PA , Bsg-PB , Bsg-PC , Bsg-PD , Bsg-PE , Bsg-PF , Bsg-PG , Bsg-PH , Bsg-PI , Bsg-PJ , CG31605-PA , CG31605-PB , CG31605-PC , CG31605-PD , CG31605-PE , CG31605-PF , CG31605-PG , CG31605-PH , CG31605-PI , CG31605-PJ , D-basigin , basigin , gelded , lethal (2) SH1217 , 5A11/Basigin , HT7 antigen , basic immunoglobulin superfamily , gp 42 , membrane glycoprotein gp42 , neurothelin , 5A11 antigen , blood-brain barrier HT7 antigen , CD147 antigen , OK blood group antigen , collagenase stimulatory factor , extracellular matrix metalloproteinase inducer , leukocyte activation antigen M6 , tumor cell-derived collagenase stimulatory factor , Basigin (Ox47 antigen or CE-9) (EMMPRIN in human) (neurothelin HT7 or 5A11 in avian) , Basignin (Ox47 antigen or CE-9) (EMMPRIN in human) (neurothelin HT7 or 5A11 in avian) , OX-47 antigen , glycoprotein CE9 , gp42/basigin/OX-47/HT7

337692 Danio rerio
318841 Drosophila melanogaster
726060 Apis mellifera
100049616 Equus caballus
12215 Mus musculus
100689246 Cricetulus griseus
770363 Gallus gallus
682 Homo sapiens
25246 Rattus norvegicus
100009229 Oryctolagus cuniculus
508716 Bos taurus
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