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Probable transcription factor specific for skin keratinocytes. Additionally we are shipping and many more products for this protein.
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bnc2 acts non-autonomously to the melanophore lineage and is expressed by hypodermal cells adjacent to chromatophores during adult pigment pattern formation.
Study indicates that BNC2 expression was down-regulated in hepatocellular tumors and cell lines showing a frequent gene deletion.
A functional SNP leading to increased expression in BNC2 is implicated in the etiology of Adolescent Idiopathic Scoliosis.
BNC2 gene mutation influencing facial pigmented spots.
Human skin color is influenced by an intergenic DNA polymorphism regulating transcription of the nearby BNC2 pigmentation gene.
follow-up studies are necessary to establish the role of BNC2 in blood-based DNA and epithelial ovarian cancer (EOC), including prospective studies to validate this region as a potential biomarker and predictor of EOC susceptibility
We identified two new skin color genes: genetic variants in UGT1A (show UGT1A1 Antibodies) were significantly associated with hue and variants in BNC2 were significantly associated with saturation.
Data indicate that the SNPs are located in the region of the BNC2 gene which is involved in ovarian development.
results suggest that the analysed polymorphisms in the BNC2 gene are unlikely to contribute to the previously reported risk of ovarian cancer in women with endometriosis
The association of BNC2 disruption with distal urethral defects and the gene's expression pattern indicate that it functions in urethral development.
the 4 recently reported SNPs,located near BNC2, SORCS1 (show SORCS1 Antibodies), GSC (show GSC Antibodies) and WDR72 (show WDR72 Antibodies) loci, affecting glycemic control in type 1 diabetes had no apparent effect on HbA1c in type 2 diabetes; but, for SORCS1 (show SORCS1 Antibodies) SNP, findings do not rule out possible relationship with HbA1c
BNC2 is a major regulator of male germ stem cells, which is required for repression of meiosis and mitosis in prospermatogonia, and for meiosis progression during spermatogenesis.
Bnc2(-/-) mice of both sexes displayed a high frequency of distal urethral defects; heterozygotes showed similar defects with reduced penetrance.
the extreme conservation of the basonuclin 2 amino acid sequence across vertebrates suggests that basonuclin 2 serves an important function, presumably as a regulatory protein of DNA transcription
gene expression profiling; structural and functional similarities with Basonuclin 1 (show BNC1 Antibodies) suggest that Basonuclin2 may play an analogous function in germ cells and skin keratinocytes
Data show that basonuclin (Bn)2 but not bn1 (show CCR6 Antibodies) colocalizes with SC35 (show SRSF2 Antibodies) in nuclear speckles, and may have a function in nuclear processing of mRNA.
Results show that basonuclin 2 is essential for the multiplication of craniofacial mesenchymal cells during embryogenesis.
Probable transcription factor specific for skin keratinocytes. May play a role in the differentiation of spermatozoa and oocytes.
, zinc finger protein basonuclin-2
, zinc finger protein basonuclin-2-like