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Beclin-1 participates in the regulation of autophagy and has an important role in development, tumorigenesis, and neurodegeneration (Zhong et al., 2009 [PubMed 19270693]).[supplied by OMIM, Jul 2010].. Additionally we are shipping Beclin 1 Kits (44) and Beclin 1 Proteins (19) and many more products for this protein.
Showing 10 out of 367 products:
Human Polyclonal Beclin 1 Primary Antibody for IHC (p), WB - ABIN388545
Baehrecke: Autophagy: dual roles in life and death? in Nature reviews. Molecular cell biology 2005
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Human Polyclonal Beclin 1 Primary Antibody for FACS, IHC (p) - ABIN388546
Lum, DeBerardinis, Thompson: Autophagy in metazoans: cell survival in the land of plenty. in Nature reviews. Molecular cell biology 2005
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Human Polyclonal Beclin 1 Primary Antibody for EIA, IHC (p) - ABIN497971
Liang, Kleeman, Jiang, Gordon, Goldman, Berry, Herman, Levine: Protection against fatal Sindbis virus encephalitis by beclin, a novel Bcl-2-interacting protein. in Journal of virology 1998
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Human Polyclonal Beclin 1 Primary Antibody for EIA, IF - ABIN497977
Gozuacik, Kimchi: Autophagy as a cell death and tumor suppressor mechanism. in Oncogene 2004
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Human Monoclonal Beclin 1 Primary Antibody for IF, IHC (p) - ABIN658976
Metzger, Saukko, Van Che, Tong, Puder, Riess, Nguyen: Age at onset in Huntington's disease is modified by the autophagy pathway: implication of the V471A polymorphism in Atg7. in Human genetics 2010
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Human Polyclonal Beclin 1 Primary Antibody for IF (p), IHC (p) - ABIN675384
Tang, Li, Wei, Zhang, Chiu, Hasenmayer, Zhang, Zhang: Resveratrol-induced apoptosis is enhanced by inhibition of autophagy in esophageal squamous cell carcinoma. in Cancer letters 2013
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Human Monoclonal Beclin 1 Primary Antibody for FACS, IHC - ABIN968976
Zhong, Wang, Li, Yan, Backer, Chait, Heintz, Yue: Distinct regulation of autophagic activity by Atg14L and Rubicon associated with Beclin 1-phosphatidylinositol-3-kinase complex. in Nature cell biology 2009
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Human Monoclonal Beclin 1 Primary Antibody for EIA, IHC (p) - ABIN1449374
Starr, Child, Wehrly, Hansen, Hwang, López-Otin, Virgin, Celli: Selective subversion of autophagy complexes facilitates completion of the Brucella intracellular cycle. in Cell host & microbe 2012
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Human Polyclonal Beclin 1 Primary Antibody for WB - ABIN658010
Oberstein, Jeffrey, Shi: Crystal structure of the Bcl-XL-Beclin 1 peptide complex: Beclin 1 is a novel BH3-only protein. in The Journal of biological chemistry 2007
Beclin1 plays an important role in vincristine-induced dopaminergic neurons toxicity.
The casp3 (show CASP3 Antibodies) cleaved product of Beclin1 promotes apoptosis induced by S1 in SKOV3 cells.
Suggest that Beclin 1 and p62 could serve as potential indicators for the prognosis of patients with non-small cell lung cancer.
in-vitro genetic depletion of beclin-1 in high glucose treated adult rat cardiomyocytes markedly inhibited the level of autophagy and subsequent apoptotic cell death.
these data indicate that IL-6 (show IL6 Antibodies) inhibits starvation-induced autophagy and that p-STAT3 (show STAT3 Antibodies) mediates the signal transduction from IL-6 (show IL6 Antibodies) to downstream proteins including Bcl-2 (show BCL2 Antibodies) and Beclin1
Suggest high expression of Beclin-1 in alveolar macrophages could be a novel biomarker for predicting anti-TB outcomes.
Beclin-1 role in antiviral immune responses: USP19 (show USP19 Antibodies) modulates antiviral immune responses by deubiquitinating Beclin-1.
Autophagy defects caused by loss of Beclin 1 are not related to chemoresistance and metastasis, but may be associated with malignant phenotype and poor prognosis of ovarian clear cell carcinoma
Decreased miR (show MLXIP Antibodies)-124-3p expression prompted breast cancer cell progression mainly by enhancing the expression of autophagy related protein, Beclin-1.
this work makes novel observations about tumor expression of Beclin-1 and challenges the accepted understanding of its role in regulating autophagy in ovarian cancer.
Data suggest that flexible helical domain of BECN1 undergoes a binding-associated disorder-to-helix transition; conserved residues critical for this interaction are essential for autophagy (here, autophagy induced by switching cells to EBSS).
suggest that neuronal death induced by decreased beclin 1 levels may also be due to impaired trophic factor signaling
FBG1 (show FBXO2 Antibodies) degrades A1AT (show SERPINA1 Antibodies)-Z through a Beclin1-dependent arm of autophagy.
Beclin 1 is required for neuron viability and regulates endosome pathways via the UVRAG (show UVRAG Antibodies)-VPS34 (show PIK3C3 Antibodies) complex.
a mechanism of inverse coregulation between BECN1 and MCL1 (show MCL1 Antibodies) significantly contributes to their opposing roles in tumorigenesis
FKBP5 (show FKBP5 Antibodies) associates with BECN1, changes its phosphorylation and protein levels and enhances markers of autophagy and autophagic flux
identifies a novel negative regulator of autophagy and suggests that RNF216 (show RNF216 Antibodies) may be a target for treatment of inflammatory diseases
Inverse co-regulation of Beclin 1 and Mcl-1 (show MCL1 Antibodies) represents a mechanism of functional counteraction in cancer.
Beclin 1-mediated autophagy alleviates cerebral ischemic injury following down-regulation of miRNA-30a.
CFTR (show CFTR Antibodies) and BECN1 function can be restored with cysteamine and EGCG in a model of the F508del-CFTR (show CFTR Antibodies) mutation
Data indicate that the expression of MAP1LC3A (show MAP1LC3A Antibodies), B and autophagy-associated genes (ATG5 (show ATG5 Antibodies), mTOR (show FRAP1 Antibodies), Beclin-1) was increased in normal pigs, while decreased in miniature pigs.
Beclin-1 participates in the regulation of autophagy and has an important role in development, tumorigenesis, and neurodegeneration (Zhong et al., 2009
beclin 1 (coiled-coil, myosin-like BCL2 interacting protein)
, beclin 1
, beclin 1 proteinBeclin-1-like protein
, myosin-like BCL2 interacting protein
, ATG6 autophagy related 6 homolog
, beclin 1 (coiled-coil, moesin-like BCL2 interacting protein)
, beclin 1 (coiled-coil, moesin-like BCL2-interacting protein)
, coiled-coil myosin-like BCL2-interacting protein
, Bcl-2-interacting protein beclin
, coiled-coil, myosin-like BCL2-interacting protein
, beclin 1 (coiled-coil, myosin-like BCL2-interacting protein)
, autophagy-related protein 6