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Beclin-1 participates in the regulation of autophagy and has an important role in development, tumorigenesis, and neurodegeneration (Zhong et al., 2009 [PubMed 19270693]).[supplied by OMIM, Jul 2010].. Additionally we are shipping Beclin 1 Kits (36) and Beclin 1 Proteins (19) and many more products for this protein.
Showing 10 out of 449 products:
Dog (Canine) Polyclonal Beclin 1 Primary Antibody for ICC, IF - ABIN259945
Liang, Kleeman, Jiang, Gordon, Goldman, Berry, Herman, Levine: Protection against fatal Sindbis virus encephalitis by beclin, a novel Bcl-2-interacting protein. in Journal of virology 1998
Show all 29 references for ABIN259945
Human Monoclonal Beclin 1 Primary Antibody for IHC, IHC (p) - ABIN314194
Ko, Lin, Flomenberg, Pestell, Howell, Sotgia, Lisanti, Martinez-Outschoorn: Glutamine fuels a vicious cycle of autophagy in the tumor stroma and oxidative mitochondrial metabolism in epithelial cancer cells: implications for preventing chemotherapy resistance. in Cancer biology & therapy 2012
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Human Polyclonal Beclin 1 Primary Antibody for IHC (p), WB - ABIN388545
Baehrecke: Autophagy: dual roles in life and death? in Nature reviews. Molecular cell biology 2005
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Human Polyclonal Beclin 1 Primary Antibody for FACS, IHC (p) - ABIN388546
Lum, DeBerardinis, Thompson: Autophagy in metazoans: cell survival in the land of plenty. in Nature reviews. Molecular cell biology 2005
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Human Polyclonal Beclin 1 Primary Antibody for EIA, IF - ABIN497977
Gozuacik, Kimchi: Autophagy as a cell death and tumor suppressor mechanism. in Oncogene 2004
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Human Monoclonal Beclin 1 Primary Antibody for IF, IHC (p) - ABIN658976
Metzger, Saukko, Van Che, Tong, Puder, Riess, Nguyen: Age at onset in Huntington's disease is modified by the autophagy pathway: implication of the V471A polymorphism in Atg7. in Human genetics 2010
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Chicken Monoclonal Beclin 1 Primary Antibody for IHC (p), IHC - ABIN314193
Botbol, Patel, Macian: Common γ-chain cytokine signaling is required for macroautophagy induction during CD4+ T-cell activation. in Autophagy 2015
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Human Monoclonal Beclin 1 Primary Antibody for EIA, IHC (p) - ABIN1449374
Starr, Child, Wehrly, Hansen, Hwang, López-Otin, Virgin, Celli: Selective subversion of autophagy complexes facilitates completion of the Brucella intracellular cycle. in Cell host & microbe 2012
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Chicken Monoclonal Beclin 1 Primary Antibody for IHC, WB - ABIN314196
Sun, Li, Zhang, Chen, Zhang, Li, Deng, Qian, Jiao, Ji, Li, Wu, Yu, Feng, Zhu: Acetylation of Beclin 1 inhibits autophagosome maturation and promotes tumour growth. in Nature communications 2015
Human Polyclonal Beclin 1 Primary Antibody for WB - ABIN658010
Oberstein, Jeffrey, Shi: Crystal structure of the Bcl-XL-Beclin 1 peptide complex: Beclin 1 is a novel BH3-only protein. in The Journal of biological chemistry 2007
Beclin1 plays an important role in vincristine-induced dopaminergic neurons toxicity.
miR-17-5p plays an important role in radiosensitivity of glioma cells by inhibiting beclin-1-mediated autophagy. Targeting miR-17-5p/beclin-1/autophagy pathway may be a promising strategy to enhance the efficacy of radiotherapy in glioma.
Low expression of BECN1 is associated with lymph node metastasis in gastric cancer.
High Beclin-1 expression (alone or in combination with SIRT1 (show SIRT1 Antibodies)) predicted shorter overall survival and relapse-free survival in gastric cancer.
High-level oxidative stress appeared to suppress the protein levels of an autophagy-regulatory protein Beclin-1 in pediatric leukemia cells, possibly through induction of miR (show MLXIP Antibodies)-93, which inhibited the translation of Beclin-1 mRNA via 3'-UTR (show UTS2R Antibodies) binding.
Beclin-1 was overexpressed in colorectal cancer tissues and was correlated with lower levels of miR (show MLXIP Antibodies)-30a. Patients with higher Beclin-1 expression levels had higher survival rates than patients with lower Beclin-1 expression levels.
Both Beclin-1 and HIF-1alpha (show HIF1A Antibodies) could be considered as important biomarkers determinants of pathogenesis and survival in acute leukemia.
Eleven primary Glioblastomas instead exhibited low beclin-1 expression and were positive for nuclear cyclin D1 (show CCND1 Antibodies); three of their recurrences exhibited an increase of beclin-1, which co-localized with cyclin D1 (show CCND1 Antibodies) in the cytoplasm. Our results suggest therapy-induced degradation of cyclin D1 (show CCND1 Antibodies) via autophagy
The present study provides evidence that miR (show MLXIP Antibodies)-409-3p targets and inhibits Beclin-1, which inhibits chemotherapy-induced autophagy and thereby enhances the chemosensitivity of colon cancer cells.
BECN1 N-terminal domain is intrinsically disordered.
Beclin 1 and ATG5 play important roles in regulating both Obatoclax-induced autophagy and apoptosis in adenoid cystic carcinoma.
provide the novel evidence that GADD45A (show GADD45A Antibodies) inhibits autophagy via impairing the BECN1-PIK3C3 (show PIK3C3 Antibodies) complex formation
in-vitro genetic depletion of beclin-1 in high glucose treated adult rat cardiomyocytes markedly inhibited the level of autophagy and subsequent apoptotic cell death.
suggest that neuronal death induced by decreased beclin 1 levels may also be due to impaired trophic factor signaling
FBG1 (show FBXO2 Antibodies) degrades A1AT (show SERPINA1 Antibodies)-Z through a Beclin1-dependent arm of autophagy.
Beclin 1 is required for neuron viability and regulates endosome pathways via the UVRAG (show UVRAG Antibodies)-VPS34 (show PIK3C3 Antibodies) complex.
a mechanism of inverse coregulation between BECN1 and MCL1 (show MCL1 Antibodies) significantly contributes to their opposing roles in tumorigenesis
FKBP5 (show FKBP5 Antibodies) associates with BECN1, changes its phosphorylation and protein levels and enhances markers of autophagy and autophagic flux
identifies a novel negative regulator of autophagy and suggests that RNF216 (show RNF216 Antibodies) may be a target for treatment of inflammatory diseases
Inverse co-regulation of Beclin 1 and Mcl-1 (show MCL1 Antibodies) represents a mechanism of functional counteraction in cancer.
Beclin 1-mediated autophagy alleviates cerebral ischemic injury following down-regulation of miRNA-30a.
Data indicate that the expression of MAP1LC3A (show MAP1LC3A Antibodies), B and autophagy-associated genes (ATG5 (show ATG5 Antibodies), mTOR (show FRAP1 Antibodies), Beclin-1) was increased in normal pigs, while decreased in miniature pigs.
Beclin-1 participates in the regulation of autophagy and has an important role in development, tumorigenesis, and neurodegeneration (Zhong et al., 2009
beclin 1 (coiled-coil, myosin-like BCL2 interacting protein)
, beclin 1
, beclin 1 proteinBeclin-1-like protein
, myosin-like BCL2 interacting protein
, ATG6 autophagy related 6 homolog
, beclin 1 (coiled-coil, moesin-like BCL2 interacting protein)
, beclin 1 (coiled-coil, moesin-like BCL2-interacting protein)
, coiled-coil myosin-like BCL2-interacting protein
, Bcl-2-interacting protein beclin
, coiled-coil, myosin-like BCL2-interacting protein
, beclin 1 (coiled-coil, myosin-like BCL2-interacting protein)
, autophagy-related protein 6