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Beclin-1 participates in the regulation of autophagy and has an important role in development, tumorigenesis, and neurodegeneration (Zhong et al., 2009 [PubMed 19270693]).[supplied by OMIM, Jul 2010].. Additionally we are shipping Beclin 1 Kits (35) and Beclin 1 Proteins (19) and many more products for this protein.
Showing 10 out of 417 products:
Dog (Canine) Polyclonal Beclin 1 Primary Antibody for ICC, IF - ABIN259945
Liang, Kleeman, Jiang, Gordon, Goldman, Berry, Herman, Levine: Protection against fatal Sindbis virus encephalitis by beclin, a novel Bcl-2-interacting protein. in Journal of virology 1998
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Human Polyclonal Beclin 1 Primary Antibody for IHC (p), WB - ABIN388545
Baehrecke: Autophagy: dual roles in life and death? in Nature reviews. Molecular cell biology 2005
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Human Polyclonal Beclin 1 Primary Antibody for FACS, IHC (p) - ABIN388546
Lum, DeBerardinis, Thompson: Autophagy in metazoans: cell survival in the land of plenty. in Nature reviews. Molecular cell biology 2005
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Human Monoclonal Beclin 1 Primary Antibody for IF, IHC (p) - ABIN387797
Metzger, Saukko, Van Che, Tong, Puder, Riess, Nguyen: Age at onset in Huntington's disease is modified by the autophagy pathway: implication of the V471A polymorphism in Atg7. in Human genetics 2010
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Human Polyclonal Beclin 1 Primary Antibody for EIA, IF - ABIN497977
Gozuacik, Kimchi: Autophagy as a cell death and tumor suppressor mechanism. in Oncogene 2004
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Human Polyclonal Beclin 1 Primary Antibody for EIA, IHC (p) - ABIN497971
Kametaka, Okano, Ohsumi, Ohsumi: Apg14p and Apg6/Vps30p form a protein complex essential for autophagy in the yeast, Saccharomyces cerevisiae. in The Journal of biological chemistry 1998
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Chicken Monoclonal Beclin 1 Primary Antibody for IHC (p), IHC - ABIN314193
Botbol, Patel, Macian: Common γ-chain cytokine signaling is required for macroautophagy induction during CD4+ T-cell activation. in Autophagy 2015
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Human Monoclonal Beclin 1 Primary Antibody for EIA, IHC (p) - ABIN1449374
Starr, Child, Wehrly, Hansen, Hwang, López-Otin, Virgin, Celli: Selective subversion of autophagy complexes facilitates completion of the Brucella intracellular cycle. in Cell host & microbe 2012
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Human Polyclonal Beclin 1 Primary Antibody for WB - ABIN658010
Oberstein, Jeffrey, Shi: Crystal structure of the Bcl-XL-Beclin 1 peptide complex: Beclin 1 is a novel BH3-only protein. in The Journal of biological chemistry 2007
Chicken Monoclonal Beclin 1 Primary Antibody for IHC, WB - ABIN314196
Sun, Li, Zhang, Chen, Zhang, Li, Deng, Qian, Jiao, Ji, Li, Wu, Yu, Feng, Zhu: Acetylation of Beclin 1 inhibits autophagosome maturation and promotes tumour growth. in Nature communications 2015
Beclin1 plays an important role in vincristine-induced dopaminergic neurons toxicity.
The present study provides evidence that miR (show MLXIP Antibodies)-409-3p targets and inhibits Beclin-1, which inhibits chemotherapy-induced autophagy and thereby enhances the chemosensitivity of colon cancer cells.
BECN1 N-terminal domain is intrinsically disordered.
Beclin 1 and ATG5 play important roles in regulating both Obatoclax-induced autophagy and apoptosis in adenoid cystic carcinoma.
we analyzed the expression status of BECN1 in AML (show RUNX1 Antibodies) and we found evidence for an association of reduced expression of BECN1 with FLT3 (show FLT3 Antibodies)-ITD mutation, adverse MK, higher age, and WBC count.
Results of our present study demonstrated that beclin 1 and LC3 (show MAP1LC3A Antibodies) immunoreactivity increased in carcinoma cells following exemestane treatment and that the status of pre-treatment stromal beclin 1 is associated with higher carcinoma cell proliferation and poor clinical and pathological responses to NAE
the BECN1-binding domain (BBD) of IRS1 (show IRS1 Antibodies) and TRS1 (show PLEKHA5 Antibodies) was found to be essential for autophagy inhibition.
Among the 101 patients, the frequency of high expression of beclin-1 was 31.7% (32/101) and that of LC3b (show MAP1LC3B Antibodies) was 46.5% (47/101). A pathologic complete response was inversely associated with LC3b (show MAP1LC3B Antibodies) expression (P = 0.003) and alterations in the expression of autophagy-related proteins
The decrease in BECN1 degradation induced by SLC9A3R1 resulted in the activity of autophagy stimulation in breast cancer cells
Collectively these results indicate miR (show MLXIP Antibodies)-30a and its downstream target gene Beclin-1 can be used in treatment of osteosarcoma chemo-resistance in the future.
The casp3 (show CASP3 Antibodies) cleaved product of Beclin1 promotes apoptosis induced by S1 in SKOV3 cells.
provide the novel evidence that GADD45A (show GADD45A Antibodies) inhibits autophagy via impairing the BECN1-PIK3C3 (show PIK3C3 Antibodies) complex formation
in-vitro genetic depletion of beclin-1 in high glucose treated adult rat cardiomyocytes markedly inhibited the level of autophagy and subsequent apoptotic cell death.
suggest that neuronal death induced by decreased beclin 1 levels may also be due to impaired trophic factor signaling
FBG1 (show FBXO2 Antibodies) degrades A1AT (show SERPINA1 Antibodies)-Z through a Beclin1-dependent arm of autophagy.
Beclin 1 is required for neuron viability and regulates endosome pathways via the UVRAG (show UVRAG Antibodies)-VPS34 (show PIK3C3 Antibodies) complex.
a mechanism of inverse coregulation between BECN1 and MCL1 (show MCL1 Antibodies) significantly contributes to their opposing roles in tumorigenesis
FKBP5 (show FKBP5 Antibodies) associates with BECN1, changes its phosphorylation and protein levels and enhances markers of autophagy and autophagic flux
identifies a novel negative regulator of autophagy and suggests that RNF216 (show RNF216 Antibodies) may be a target for treatment of inflammatory diseases
Inverse co-regulation of Beclin 1 and Mcl-1 (show MCL1 Antibodies) represents a mechanism of functional counteraction in cancer.
Beclin 1-mediated autophagy alleviates cerebral ischemic injury following down-regulation of miRNA-30a.
Data indicate that the expression of MAP1LC3A (show MAP1LC3A Antibodies), B and autophagy-associated genes (ATG5 (show ATG5 Antibodies), mTOR (show FRAP1 Antibodies), Beclin-1) was increased in normal pigs, while decreased in miniature pigs.
Beclin-1 participates in the regulation of autophagy and has an important role in development, tumorigenesis, and neurodegeneration (Zhong et al., 2009
beclin 1 (coiled-coil, myosin-like BCL2 interacting protein)
, beclin 1
, beclin 1 proteinBeclin-1-like protein
, myosin-like BCL2 interacting protein
, ATG6 autophagy related 6 homolog
, beclin 1 (coiled-coil, moesin-like BCL2 interacting protein)
, beclin 1 (coiled-coil, moesin-like BCL2-interacting protein)
, coiled-coil myosin-like BCL2-interacting protein
, Bcl-2-interacting protein beclin
, coiled-coil, myosin-like BCL2-interacting protein
, beclin 1 (coiled-coil, myosin-like BCL2-interacting protein)
, autophagy-related protein 6